A5101462620- Sleep and related disorders
- COVID-19 and Mental Health
- Posttraumatic Stress Disorder Research
- Esophageal Cancer Research and Treatment
- MicroRNA in disease regulation
- SARS-CoV-2 and COVID-19 Research
- Orthopaedic implants and arthroplasty
- Circular RNAs in diseases
- Migration, Health and Trauma
- Immune cells in cancer
- Child and Adolescent Psychosocial and Emotional Development
- Epigenetics and DNA Methylation
- Circadian rhythm and melatonin
- Hip disorders and treatments
- Ferroptosis and cancer prognosis
- Nutritional Studies and Diet
- Mental Health Research Topics
- Cancer-related molecular mechanisms research
- Schizophrenia research and treatment
- Radiomics and Machine Learning in Medical Imaging
- Polysaccharides and Plant Cell Walls
- Cancer, Hypoxia, and Metabolism
- Resilience and Mental Health
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
Zhejiang Ocean University
2024-2025
University of Oxford
2022-2025
Nanjing Medical University
2023-2025
Taiyuan Normal University
2025
Guiyang Medical University
2024
Shanghai Construction Group (China)
2022-2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
First Affiliated Hospital of University of South China
2021-2024
University of South China
2021-2024
Background Despite tremendous advances in cancer research, breast (BC) remains a major health concern and is the most common affecting women worldwide. Breast highly heterogeneous with potentially aggressive complex biology, precision treatment for specific subtypes may improve survival patients. Sphingolipids are important components of lipids that play key role growth death tumor cells increasingly subject new anti-cancer therapies. Key enzymes intermediates sphingolipid metabolism (SM) an...
A common problem that is encountered in medical applications the overall homogeneity of survival distributions when two curves cross each other. survey demonstrated under this condition, which was an obvious violation assumption proportional hazard rates, log-rank test still used 70% studies. Several statistical methods have been proposed to solve problem. However, many applications, it difficult specify types differences and choose appropriate method prior analysis. Thus, we conducted...
Tumor-associated macrophages (TAMs) play a critical role in the tumor inflammatory microenvironment and facilitate growth metastasis. Most types of tumors aberrantly express microRNAs (miRNAs), which can be transferred between cells by exosomes regulate gene expression recipient cells, but it remains unclear whether tumor-derived miRNAs are TAM phenotype. We report that mouse 4T1 breast cancer cell-derived enhanced IL-1β, IL-6, TNF-α inhibition 4T1-cell exosome secretion through short...
Abstract Understanding the underlying molecular mechanisms behind ADE of SARS-CoV-2 is critical for development safe and effective therapies. Here, we report that two neutralizing mAbs, MW01 MW05, could enhance infection pseudovirus on FcγRIIB-expressing B cells. X-ray crystal structure determination S trimer-binding modeling showed MW05 bind to RBDs in trimer with both “up” “down” states. While, mAb MW07, which has no activity only binds RBD state. Monovalent completely diminished compared...
Abstract The lung is the primary respiratory organ in human, which proximal airway and distal alveoli are responsible for air conduction gas exchange, respectively. However, regulation of proximal–distal patterning at embryonic stage human development largely unknown. Here we investigated early embryos weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, obtained a transcriptomic atlas 169,686 cells. We observed discernible gene expression patterns epithelia...
The fall armyworm, Spodoptera frugiperda (Noctuidae: Lepidoptera), is a wide-reaching notorious insect pest of important cereal crops, which has developed resistance to multiple classes insecticides. It invaded the Sichuan Province China in 2019. In this study, we performed monitoring insecticides for 11 field-collected populations from Sichuan, and all were susceptible emamectin benzoate chlorpyrifos. variations level indoxacarb (resistance ratio (RR), 9.23-45.53-fold), spinetoram (RR,...
Background Although breast cancer (BC) treatment has entered the era of precision therapy, prognosis is good in case comprehensive multimodal such as neoadjuvant, endocrine, and targeted therapy. However, due to its high heterogeneity, some patients still cannot benefit from conventional have poor survival prognoses. Amino acids their metabolites affect tumor development, alter microenvironment, play an increasingly obvious role immune response regulation cell function, are involved acquired...
Increasing evidence reveals that breast cancer stem cells (BCSCs) subtypes with distinct properties are regulated by their abnormal metabolic changes; however, the specific molecular mechanism and its relationship tumor microenvironment (TME) not clear. In this study, we explored of lactate dehydrogenase A (LDHA), a crucial glycolytic enzyme, in maintaining stemness BCSCs plasticity, promoting interaction associated macrophages (TAMs). Firstly, expression LDHA tissues was much higher than...
Considerable studies have explored the potential mechanisms between trauma exposure and PTSD, but little is known about role of sleep problems resilience in this relationship. To address research gap, present study examined whether mediated relationship earthquake PTSD symptoms, mediating process was moderated by resilience. A sample 1,342 adolescents ( M age = 15.54 years, SD 1.26) completed questionnaires regarding exposure, problems, resilience, symptoms 12 months after a devastating...
Abstract The quality of weld seams is critical to the performance and safety industrial products. Traditional manual inspection methods are inefficient prone inaccuracies, particularly in complex environments. To address these challenges, this study introduces an automated seam dimensional measurement approach based on enhanced U-Net architecture, termed AM U-Net. By integrating wavelet depth separable convolution, attention mechanisms, multi-scale feature fusion, effectively captures...
Abstract The aim was to analyze the association between exosomal microRNA (miR)‐766‐3p expression levels in serum and prognosis of esophageal squamous cell carcinoma (ESCC). global miRNA ESCC patients measured by microarray. Quantitative real‐time PCR used candidate miRNAs both tissues from patients. Wilcoxon tests were applied evaluate clinical characteristics their with miR‐766‐3p. A Cox regression model identify prognostic factors. effects miR‐766‐3p on migration invasion examined using...