A5102750385- Seed and Plant Biochemistry
- Genetic Mapping and Diversity in Plants and Animals
- Single-cell and spatial transcriptomics
- Hibiscus Plant Research Studies
- Pluripotent Stem Cells Research
- Advances in Cucurbitaceae Research
- GABA and Rice Research
- Immune Cell Function and Interaction
- Mast cells and histamine
- CRISPR and Genetic Engineering
- Plant Disease Resistance and Genetics
- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- Rice Cultivation and Yield Improvement
- Mosquito-borne diseases and control
- Allergic Rhinitis and Sensitization
- Genetics and Plant Breeding
- Food composition and properties
- Renal and related cancers
- RNA modifications and cancer
- Extracellular vesicles in disease
- Food Allergy and Anaphylaxis Research
- Viral Infections and Vectors
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
Guangzhou Institutes of Biomedicine and Health
2017-2025
Chinese Academy of Sciences
2017-2025
Guangzhou Medical University
2017-2024
Fujian Agriculture and Forestry University
2014-2024
Fujian Electric Power Survey & Design Institute
2023-2024
Shanghai Jiao Tong University
2014-2024
Shanghai First People's Hospital
2014-2024
Hainan 301 Hospital
2024
Ministry of Agriculture and Rural Affairs
2020-2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2020-2023
Although previous studies have revealed the contribution of an initial high level dengue virus replication to severe and potentially life-threatening diseases hemorrhagic fever (DHF) shock syndrome, involvement in immunopathological processes during transition from defervescence, which is a critical stage determining progression DHF, has not been appreciated. Previously, we reported that can be detected immune complexes patients with DHF this period.We investigated plasma viral load,...
The effects of cadmium stress on the growth, antioxidative enzymes and lipid peroxidation in two kenaf plants, Fuhong 991 ZM412, were analysed under control (0.5-strength Hoagland's nutrient solution) or five levels solution containing different concentrations Cd2+). leaves roots cadmium-stressed plants harvested after 3 wk. At same Cd concentration, tolerance index was higher than that indicating may be more tolerant to ZM412. superoxide dismutase (SOD), catalase activity (CAT) peroxidase...
Abstract Establishing saturated mutagenesis in a specific gene through editing is an efficient approach for identifying the relationships between mutations and corresponding phenotypes. CRISPR/Cas9-based sgRNA library screening often creates indel with multiple nucleotides. Single base editors dual deaminase-mediated can achieve only one two types of substitutions, respectively. A new glycosylase editor (CGBE) system, which uracil inhibitor (UGI) replaced uracil-DNA (UNG), was recently...
Abstract The lung is the primary respiratory organ in human, which proximal airway and distal alveoli are responsible for air conduction gas exchange, respectively. However, regulation of proximal–distal patterning at embryonic stage human development largely unknown. Here we investigated early embryos weeks 4–8 post fertilization (Carnegie stages 12–21) using single-cell RNA sequencing, obtained a transcriptomic atlas 169,686 cells. We observed discernible gene expression patterns epithelia...
Exosomes are nanovesicles released by different cell types, such as dendritic cells (DCs), mast (MCs), and tumor cells. of origin play a role in antigen presentation modulation immune response to infectious disease. In this study, we demonstrate that CD4 + T colocated peritoneal lymph nodes from BALB/c mouse. Further, bone marrow-derived (BMMCs) constitutively release exosomes, which express CD63 OX40L. BMMC-exosomes partially promoted the proliferation significantly enhanced differentiation...
Kenaf is an annual crop that widely cultivated as a source of bast (phloem) fibres, the phytoremediation heavy metal-contaminated farmlands and textile-relevant compounds. Leaf shape played unique role in kenaf improvement, due to inheritance single locus association with fibre development typical lobed-leaf varieties. Here we report high-quality genome assembly annotation for var. 'Fuhong 952' 1078 Mbp 66 004 protein-coding genes integrating single-molecule real-time sequencing,...
Cell fate decision involves rewiring of the genome, but remains poorly understood at chromatin level. Here, we report that remodeling complex NuRD participates in closing open early phase somatic reprogramming. Sall4, Jdp2, Glis1 and Esrrb can reprogram MEFs to iPSCs efficiently, only Sall4 is indispensable capable recruiting endogenous components NuRD. Yet knocking down reduces reprogramming modestly, contrast disrupting known Sall4-NuRD interaction by mutating or deleting interacting motif...
Summary Cultivated jute, which comprises the two species Corchorus capsularis and C. olitorius , is second most important natural fibre source after cotton. Here we describe chromosome‐level assemblies of genomes both cultivated species. The are each comprised seven pseudo‐chromosomes, with assembly consisting 336 Mb 25,874 genes containing 361 28 479 genes. Although exhibit collinearity, genome contains 25 additional sequences than that 13 putative inversions, might give a hint to...
ABSTRACT Integration of single-cell and spatial transcriptome represents as a fundamental strategy to enhance data quality. However, existing methods for mapping coordinates struggle with large-scale datasets comprising millions cells. Here, we introduce Zmap, an intelligent region-allocation method inspired by the region-of-interest (ROI) concept from image processing. By using gradient descent, Zmap allocates cells structured regions that matching most significant biological information,...
Polycomb repressive complex 1 (PRC1) plays essential roles in cell-fate determination. Recent studies have found that the composition of mammalian PRC1 is particularly varied and complex; however, little known about functional consequences these variant complexes on Here, we show Kdm2b promotes Oct4-induced somatic reprogramming through recruitment a (PRC1.1) to CpG islands (CGIs). Furthermore, find bone morphogenetic protein (BMP) represses Oct4/Kdm2b-induced selectively. Mechanistically,...
Genetic diversity analysis and DNA finger printing are very useful in breeding programs, seed conservation management. Jute (Corchorus spp.) is the second most important natural fiber crop after cotton. fingerprinting studies jute using SSR markers limited. In this study, 58 accessions, including two control varieties (Huangma 179 Kuanyechangguo) from official variety registry China were evaluated with 28 pairs of primers. A total 184 polymorphic loci identified. Each primer detected 3 to 15...
Genetic mapping and quantitative trait locus (QTL) detection are powerful methodologies in plant improvement breeding. White jute (Corchorus capsularis L.) is an important industrial raw material fiber crop because of its elite characteristics. However, construction a high-density genetic map identification QTLs has been limited white due to lack sufficient molecular markers. The specific amplified fragment sequencing (SLAF-seq) strategy combines locus-specific amplification high-throughput...
Reactions between arynes and alkyl sulfides have been extensively studied over the past few decades. These reactions commonly end with a dealkylation process thus deliver thioethers as final products. In contrast, transformation described furnishes valuable triarylsulfonium salts, in lieu of thioethers, from diarylsulfides. The reaction features mild conditions broad substrate scope. A suite functional groups such ketones, esters, nitriles, aryl ethers halides is tolerated, which can be...
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining signaling cascade that regulates release cell-derived inflammatory mediators is an attractive therapeutic strategy to treat Orosomucoid-like-3 (ORMDL3) endoplasmic reticulum stress (ERS)-induced unfolded protein response (UPR) and autophagy. Although ERS/UPR/autophagy pathway crucial Ag-induced activation, it unknown whether ORMDL3 during activation. In this...
Abstract Background Single-cell RNA sequencing is becoming a powerful tool to identify cell states, reconstruct developmental trajectories, and deconvolute spatial expression. The rapid development of computational methods promotes the insight heterogeneous single-cell data. An increasing number tools have been provided for biological analysts, which two programming languages- R Python are widely used among researchers. complementary, as many implemented specifically in or Python. However,...
Jute is considered one of the most important crops for fiber production and multipurpose usages. Caffeoyl-CoA 3-O-methyltransferase (CCoAOMT) a crucial enzyme involved in lignin biosynthesis plants. The potential functions CCoAOMT jute have been reported several studies. However, little known about evolution gene family, either their expression level at different developing stages cultivars, as well under abiotic stresses including salt drought stress.In present study, 66 genes from 12...