A5100339103- Cell death mechanisms and regulation
- Plant Toxicity and Pharmacological Properties
- Drug-Induced Hepatotoxicity and Protection
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Plant Reproductive Biology
- Plant Molecular Biology Research
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Advanced Glycation End Products research
- S100 Proteins and Annexins
- Liver Disease Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Alkaloids: synthesis and pharmacology
- Photosynthetic Processes and Mechanisms
- TGF-β signaling in diseases
- 3D Printing in Biomedical Research
- Chronic Kidney Disease and Diabetes
- Protein Tyrosine Phosphatases
- Ginger and Zingiberaceae research
- Genomics, phytochemicals, and oxidative stress
- Mitochondrial Function and Pathology
- FOXO transcription factor regulation
- Phagocytosis and Immune Regulation
Southwest Medical University
2021-2025
Macau University of Science and Technology
2023-2025
First Hospital of Lanzhou University
2022-2024
Lanzhou University
2022-2024
First Affiliated Hospital of Kunming Medical University
2023
Kunming Medical University
2023
Affiliated Hospital of Southwest Medical University
2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2022
Chongqing Medical University
2022
China Pharmaceutical University
2022
Approximately 3,500 mammalian genes are predicted to be secreted or single-pass transmembrane proteins. The function of the majority these is still unknown, and a number encoded proteins might find use as new therapeutic agents themselves targets for small molecule antibody drug development. To analyze physiological activities extracellular proteome, we developed large-scale, high-throughput protein expression, purification, screening platform. For this study, complete human proteome was...
Exosomes are nanovesicles released by different cell types, such as dendritic cells (DCs), mast (MCs), and tumor cells. of origin play a role in antigen presentation modulation immune response to infectious disease. In this study, we demonstrate that CD4 + T colocated peritoneal lymph nodes from BALB/c mouse. Further, bone marrow-derived (BMMCs) constitutively release exosomes, which express CD63 OX40L. BMMC-exosomes partially promoted the proliferation significantly enhanced differentiation...
The incidence of rheumatoid arthritis (RA) is increasing with age. DNA fragments known to accumulate in certain autoimmune diseases, but the mechanistic relationship among ageing, and RA pathogenesis remain unexplored. Here we show that accumulation fragments, age regulated by exonuclease TREX1, promotes abnormal activation immune system an adjuvant-induced (AIA) rat model. Local overexpression TREX1 suppresses synovial inflammation rats, while conditional genomic deletion AIA rats result...
Background: Middle-aged and elderly individuals may experience detrimental health effects due to ischemic stroke (IS). The inflammatory response triggered during IS exacerbates neuronal damage, becoming a barrier effective treatment leading poor patient prognosis. Nevertheless, the specific role of microglia in by remains mostly unclear. primary target this investigation is study neuroinflammatory impact lycorine (LYC) process. Our objective evaluate whether LYC deploys its anti-inflammatory...
AIM:To investigate the effects of blueberry on hepatic fibrosis and NF-E2-related factor 2 (Nrf2 ) transcription in rats. METHODS:Forty-five male Sprague-Dawley rats were randomly divided into control group (A); CCl4-induced (B); prevention (C); Dan-shao-hua-xian capsule (DSHX) (D); + DSHX (E).Liver was induced by subcutaneous injection CCl4 a high-lipid/low-protein diet for 8 wk (except group).The level hyaluronic acid (HA) alanine aminotransferase (ALT) serum examined.The activity...
Osteosarcoma (OS) is the most common malignant bone tumor worldwide and associated with a poor prognosis, often being accompanied by lung metastasis at an early stage. At present, there are several side‑effects OS clinical treatment of OS, effects unsatisfactory. Thus, urgent need for development safe effective novel drugs OS. Schisandrin B (Sch B) has been previously demonstrated to exhibit antitumor properties. The present study was focused on Sch cells (143B, MG63, Saos2 U2OS) in vitro...
Systemic vascular impairment is the most common complication of diabetes. Advanced glycation end products (AGEs) can exacerbate diabetes-related damage by affecting intima and media through a variety mechanisms. In study, we demonstrated that AGEs their membrane receptor RAGE could induce differentiation EPCs into osteoblasts under certain circumstances, thereby promoting accelerated atherosclerosis. Differentiation was confirmed positive staining for DiI-acetylated fluorescently labeled...
Pyrrolizidine alkaloids are naturally occurring genotoxic chemicals produced by a large number of plants. The high toxicity many pyrrolizidine has caused considerable loss free-ranging livestock due to liver and pulmonary lesions. Chronic exposure toxic laboratory animals induces cancer. This investigation studies the metabolic activation retrorsine, representative tumorigenic alkaloid, shows that mechanism is correlated tumorigenicity retrorsine. Metabolism retrorsine microsomes F344 female...
Gastric carcinoma (GC) is one of the most common malignant tumors worldwide, and ranks fifth in incidence top 5 tumor-associated mortality. Unfortunately, molecular mechanisms contributing to GC development are still unclear, urgently requiring more studies. It has been proposed that multifunctional regulator receptor-interacting protein 2 (RIPK2) both a induces stomach cancer its complications such as cachexia. However, potential function RIPK2 on regulation largely unknown. Moreover,...
Helicobacter pylori (H. pylori) infection exhibits a familial clustering phenomenon. To investigate the prevalence of H. infection, identify associated factors, and analyze patterns transmission within families residing in community. From July 2021 to September 2021, total 191 (519 people) two randomly chosen community health service centers Chengguan District Lanzhou Gansu Province, were recruited fill out questionnaires tested for infection. Individuals followed up again from April 2023...
Environmental stress induces the synthesis of glucose-regulated proteins (Grps) in endoplasmic reticulum (ER) and heat shock (Hsps) cytoplasm. Iodoacetamide (IDAM), a prototypical alkyating agent, both Grp Hsp renal epithelial cells causes necrosis which is prevented by prior activation ER response (pre-ER stress) [Liu, H., et al. (1997) J. Biol. Chem. 272, 21751−21759]. In this study, we examined biochemical pathways leading to IDAM-induced apoptosis investigated role apoptotic cell death....
Abstract β‐benzene hexachloride (β‐BHC), the major metabolite of benzene‐hexachloride (BHC), is a weak estrogen‐like chemical. It known persistent organic pollutant and male reproductive toxicant. However, mechanism by which β‐BHC exposure causes toxicity remains unknown. In present study, rat Sertoli cells were used to investigate molecular involved in β‐BHC‐induced system. The results indicated that at over 30 μM showed induction apoptotic cell death. could induce elevation reactive oxygen...
Background. Diabetes mellitus is a clinical syndrome caused by genetic and environmental factors. Growing evidence suggests that exposure to endocrine disruptors activation of NLRP3 inflammasome signaling play vital role in diabetes. However, it unclear how PCB118, common disruptor, contributes the incidence diabetes, its specific mechanism action unknown. In this study, we explored whether ROS-induced priming were related PCB118 mouse islet β-TC-6 cells mechanisms Methods. Mouse cultured...
To establish nomograms integrating serum lactate levels and traditional risk factors for predicting diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients.
To explore the mechanisms of large-conductance calcium-activated potassium channel (BKCa) involved in inflammatory response sepsis.The serum levels BKCa were measured by enzyme-linked immunosorbent assay (ELISA) patients with sepsis (28 cases), common infection (25 cases) and healthy people cases). The relationship between acute physiology chronic health evaluation II (APACHE II) analyzed. Cultured RAW 264.7 cells stimulated lipopolysaccharide (LPS). In some experiments, a cell model was...