A5102980191- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Tracheal and airway disorders
- Neonatal Respiratory Health Research
- Menopause: Health Impacts and Treatments
- Lymphatic System and Diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Renal and related cancers
- Antibiotic Resistance in Bacteria
- Spaceflight effects on biology
- Axon Guidance and Neuronal Signaling
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Tumors and Oncological Cases
- Bacterial biofilms and quorum sensing
- Biomedical Ethics and Regulation
- Congenital Diaphragmatic Hernia Studies
- Developmental Biology and Gene Regulation
Columbia University Irving Medical Center
2022-2024
Columbia University
2022-2024
Center for Life Sciences
2015
Peking University
2010-2015
Pluripotent stem cells can be induced from somatic cells, providing an unlimited cell resource, with potential for studying disease and use in regenerative medicine. However, genetic manipulation technically challenging strategies such as nuclear transfer used reprogramming limit their clinical applications. Here, we show that pluripotent generated mouse at a frequency up to 0.2% using combination of seven small-molecule compounds. The chemically resemble embryonic terms gene expression...
Estrogen is imperative to mammalian reproductivity, metabolism, and aging. However, the hormone activating estrogen receptor (ERs) α can cause major safety concerns due enrichment of ERα in female tissues certain malignancies. In contrast, ERβ more broadly expressed metabolic skin. Thus, it desirable generate selective agonist conjugates for maximizing therapeutic effects ERs while minimizing risks activation. Here, we report design production small molecule containing non-steroid agonists...
Abstract The generation of induced pluripotent stem (iPS) cells holds great promise in regenerative medicine. use the transcription factors Oct4, Sox2, Klf4 and c-Myc for reprogramming is extensively documented, but comparatively little known about soluble molecules promoting reprogramming. Here we identify secreted cue Netrin-1 its receptor DCC, described their respective survival/death functions normal oncogenic contexts, as modulators. In various somatic cells, found that accompanied by a...
Tissue lymphatic vessels network plays critical roles in immune surveillance and tissue homeostasis response to pathogen invasion, but how system per se is remolded during infection less understood. Here, we observed that influenza induces a significant increase of vessel numbers the lung, accompanied with extensive proliferation endothelial cells (LECs). Single-cell RNA sequencing illustrated heterogeneity LECs, identifying novel PD-L1+ subpopulation present viral not at steady state....
SUMMARY Basal cells are multipotent stem of a variety organs, and in the lung known as crucial components airway epithelium. However, it remains unclear how diverse basal whether distinct subpopulations respond differently to challenges. Using single cell RNA-sequencing functional approaches, we report significant previously underappreciated degree heterogeneity pool, leading identification six murine trachea. Among these found two major comprising most stem-like progenitor compartment, but...