A5023348560- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Cancer, Stress, Anesthesia, and Immune Response
- Neuropeptides and Animal Physiology
- Pharmacological Receptor Mechanisms and Effects
- Solid State Laser Technologies
- RNA regulation and disease
- interferon and immune responses
- NF-κB Signaling Pathways
- Advanced Fiber Laser Technologies
- Cytomegalovirus and herpesvirus research
- Toxoplasma gondii Research Studies
- Luminescence Properties of Advanced Materials
- Multicomponent Synthesis of Heterocycles
- RNA modifications and cancer
- Synthesis of heterocyclic compounds
- Galectins and Cancer Biology
- Face recognition and analysis
- Evacuation and Crowd Dynamics
- Angiogenesis and VEGF in Cancer
- Phenothiazines and Benzothiazines Synthesis and Activities
- T-cell and B-cell Immunology
- Lymphatic System and Diseases
- Hydrogen's biological and therapeutic effects
Columbia University
2018-2025
Columbia University Irving Medical Center
2020-2024
Shanghai Institute of Ceramics
2024
Chinese Academy of Sciences
2010-2024
University of Chinese Academy of Sciences
2024
National Institute of Allergy and Infectious Diseases
2014-2020
National Institutes of Health
2014-2019
Sichuan University
2019
Center for Excellence in Molecular Cell Science
2010-2015
Shanghai Institutes for Biological Sciences
2010-2015
Inflammatory ILC2s are itinerant sentinels Group 2 innate lymphoid cells (ILC2s) a population of immune that play important roles in tissue homeostasis and barrier immunity to helminths. Recent work has suggested primarily long-term residents tissues do not readily recirculate. Huang et al. now demonstrate, however, these findings necessarily hold true for the interleukin-25 (IL-25)–responsive KLRG1 hi “inflammatory” ILC2 (iILC2) subset (see Perspective by Mjösberg Rao). In response...
Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an important negative regulator KLRG1+ ILC-2 function both mice humans. Increase cell numbers was attributed intrinsic defect signaling, which resulted enhanced STAT5 activation. During Nippostrongylus brasiliensis infection, a significant expansion subsets...
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly understood. Viral double-stranded (dsRNA) triggers innate immune responses when sensed by host pattern recognition receptors (PRRs) present in all cell types. Here, we report human neurons intrinsically carry exceptionally high levels immunostimulatory dsRNAs identify long 3'UTRs as giving rise to neuronal dsRNA structures....
Conventional CD4+ T cells are composed of naïve, pathogen-specific memory, and pathogen-independent memory-phenotype (MP) under steady state. Naïve memory play key roles in adaptive immunity, whereas the homeostatic mechanisms regulating generation MP their biological functions unclear. We show that autonomously generated from peripheral naïve absence infectious stimulation a cell receptor (TCR)- CD28-dependent manner. further demonstrate contain T-bethi subpopulation is continuously by...
Triple-negative breast cancer (TNBC) responds poorly to immunotherapy due insufficient immunogenicity and highly immunosuppressive tumor microenvironment (TME). Herein, an intelligent calcium/cobalt-based nanomodulator (Ca,Co)CO
<div>Abstract<p>The vagal nerve is linked to tumorigenesis in multiple tissues, including small cell lung cancer (SCLC). However, the role of sympathetic neurons SCLC development remains unknown. In this study, we observed a significant reduction tumor growth following chemical denervation local nerves mouse model SCLC. Further study identified that β2-adrenergic receptor (ADRB2) expression on cells mediated cross-talk with fibers. Genetic deletion or pharmacological inhibition...
<p>PKA inhibition (PKAi) reduces the growth of primary human SCLC cells</p>
<p>Co-culture with stellate ganglia (SG) promotes the growth of mouse SCLC</p>
<p>ADRB2 regulates the growth of human SCLC cells</p>
<p>High levels of ADRB2 promote the growth mouse SCLC</p>
<p>Sympathetic and parasympathetic nerve fibers in mouse SCLC</p>
<p>ICI treatment reduces the growth of SCLC</p>
Abstract NF-κB is a family of important transcription factors that modulate immunity, development, inflammation, and cancer. The biological activity subjected to various spatial temporal regulations. Bioinformatics analysis predicts CITED2 topologically close in the protein interaction networks. In this study, we show ectopic expression or knockdown attenuates potentiates, respectively, NF-κB–responsive genes. Mechanistically, constitutively localizes inside nucleus interacts specifically...
Viral infection induces innate immunity and apoptosis. Apoptosis is an effective means to sacrifice virus-infected host cells therefore restrict the spread of pathogens. However, underlying mechanisms this process are still poorly understood. Here, we show that mitochondrial antiviral signaling protein (MAVS/VISA/Cardif/IPS-1) critical for SeV (Sendai virus)-induced MAVS specifically activates c-Jun N-terminal kinase 2 (JNK2) but not other MAP kinases. Jnk2-/- cells, Jnk1-/- unable initiate...