A5021791991- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Biosimilars and Bioanalytical Methods
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Genomics and Rare Diseases
- Cancer Genomics and Diagnostics
- Cardiac tumors and thrombi
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- T-cell and B-cell Immunology
- Congenital heart defects research
- Safe Handling of Antineoplastic Drugs
National Institutes of Health
2023-2024
National Cancer Institute
2024
Center for Cancer Research
2024
University of Oxford
2018
Centre for Human Genetics
2018
Newcastle University
2017-2018
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2017
Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an important negative regulator KLRG1+ ILC-2 function both mice humans. Increase cell numbers was attributed intrinsic defect signaling, which resulted enhanced STAT5 activation. During Nippostrongylus brasiliensis infection, a significant expansion subsets...
Genomic instability, which is a hallmark of cancer, generally thought to occur in the middle late stages tumourigenesis, following acquisition permissive molecular aberrations such as TP53 mutation or whole genome doubling. Tumours with somatic POLE exonuclease domain mutations are notable for their extreme genomic instability (their burden among highest human cancer), distinct mutational signature, lymphocytic infiltrate, and excellent prognosis. To what extent these characteristics...
Studies on the dynamic changes occurring in tumor microenvironment (TME) following CAR-T cell therapy have been confounded by host lymphodepletion, multiple dosing and immunodeficient models. Here, a nanobody-based, mouse mesothelin-targeting (A101) was developed, achieving effective primary suppression, metastasis reduction, improved survival after single dose immunocompetent, syngeneic models without lymphodepletion. Temporal profiling using RNA sequencing revealed initial downregulation...
Carney complex (CNC) is a syndrome characterized by hyperplasia of endocrine organs and may present with clinical features Cushing acromegaly due to functional adrenal pituitary gland tumors. CNC has been linked mutations in the regulatory subunit protein kinase A type I-alpha (PRKAR1A) gene.Tissue samples were taken from hypothalamus or thalamus tumors patients adenomas seen operated on neurosurgeon Harvey between 1913 1932. Following DNA extraction, sequencing for genes interest was...
Abstract Purpose: Patients with gastric and colorectal cancers that have progressed after standard therapies poor prognosis. Given the high expression of mesothelin in these tumor types, we examined potential utility anti-mesothelin hYP218 CAR T cells to treat cancers. Experimental Design: Cell surface a panel cancer cell-lines was analyzed using flow cytometry. In vitro efficacy against cell lines evaluated cytotoxicity cytokine release assays. vivo studied (HGC27) (SW48) xenografts NSG...
Abstract Nanobody-based chimeric antigen receptor (CAR) T cells are currently being tested in early phase clinical trials against blood and solid tumor antigens. Owing to the low molecular weight, increased stability, immunogenicity of nanobodies, nanobody-based CAR an attractive alternative antibody-based for improving vivo persistence overcoming loss tumors. However, no such agent has been described that can target mesothelin, a is highly expressed mesotheliomas, pancreatic, ovarian, lung...