A5071868000- Computational Drug Discovery Methods
- Phytochemistry and biological activity of medicinal plants
- Cancer therapeutics and mechanisms
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Natural Antidiabetic Agents Studies
- CAR-T cell therapy research
- Autophagy in Disease and Therapy
- Phytochemicals and Antioxidant Activities
- Bioactive natural compounds
- Phytochemical Studies and Bioactivities
- Silymarin and Mushroom Poisoning
- Drug-Induced Hepatotoxicity and Protection
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Safe Handling of Antineoplastic Drugs
- Microbial Metabolism and Applications
- Phytochemicals and Medicinal Plants
- Immune Cell Function and Interaction
- Tannin, Tannase and Anticancer Activities
- PI3K/AKT/mTOR signaling in cancer
- Epigenetics and DNA Methylation
- Biochemical and biochemical processes
- Cancer-related Molecular Pathways
- Medicinal Plants and Neuroprotection
National Institutes of Health
2024
National Cancer Institute
2024
Center for Cancer Research
2024
Academy of Scientific and Innovative Research
2017-2022
Indian Institute of Integrative Medicine
2017-2022
In the present study, a novel series of 3-pyrimidinylazaindoles were designed and synthesized using bioinformatics strategy as cyclin-dependent kinases CDK2 CDK9 inhibitors, which play critical roles in cell cycle control regulation transcription. The approach gives new dimensions to existing SAR opens opportunity for lead optimizations from comparatively inexpensive starting materials. study led identification alternative candidate 4ab with nanomolar potency against potent antiproliferative...
AKT, a serine threonine kinase, exists in three different isoforms and is known for regulating several biological processes including tumorigenesis. In this study, we investigated the expression net effect of individual triple negative breast cancers response to cisplatin treatment using cellular, mice models clinical samples. Interestingly, analysis expressions AKT samples showed relatively higher AKT1 primary tissues; whereas lung liver metastatic elevated AKT2. Similarly, triple-negative...
Prunella vulgaris, commonly known as self-heal, has been extensively used in the traditional system of medicines. The plant found to contain a number bioactive molecules including those having radical scavenging property which indicates its potential for treatment diseases are induced by free damage like drug-induced hepatotoxicity. current study was undertaken investigate flavonoid and total phenolic content evaluate hepatoprotective various extracts obtained from floral spikes P. vulgaris....
Lysosomal biogenesis plays a vital role in cell fate. Under certain conditions, excessive lysosomal leads to susceptibility for membrane permeabilization resulting various pathological conditions including death. In cancer cells apoptosis machinery becomes dysregulated during the course of treatment, thus allows escape apoptosis. So it is therefore imperative identify cytotoxic agents that exploit non-apoptotic mechanisms Our study showed pancreatic treated with SDS-203 triggered an...
Low therapeutic efficacy and drug-induced systemic toxicity of currently used anti-cancerous chemotherapeutic agents are major compelling factors for finding out clinically efficient molecules with high efficiency less toxicity.The current research work was undertaken to evaluate the anticancer potential Myricanol- 9-acetate (MA), a novel naturally occurring derivative myricanol.MCF-7, MiaPaCa-2, HCT 116 were cytotoxicity determination MA ML (Myricanol) by MTT assay. The mechanistic study...
The disclosed study reveals isolation, characterization and anticancer evaluation of Rumex dentatus. extracts isolated compounds were used for cytotoxic activity against (lung (A549), pancreatic (MIAPaCa), colon (HCT-116), breast (MDA-MB-231) (MDA-MB-468) cell lines. screened cytotoxicity using MTT colorimetric assay. Out all extracts, methanolic (30) %: chloroform fraction (TAW6) with 75.01% inhibition at a concentration 100 µg/mL was observed. selected further processed column...
Abstract Purpose: Patients with gastric and colorectal cancers that have progressed after standard therapies poor prognosis. Given the high expression of mesothelin in these tumor types, we examined potential utility anti-mesothelin hYP218 CAR T cells to treat cancers. Experimental Design: Cell surface a panel cancer cell-lines was analyzed using flow cytometry. In vitro efficacy against cell lines evaluated cytotoxicity cytokine release assays. vivo studied (HGC27) (SW48) xenografts NSG...