A5038737377- Computational Drug Discovery Methods
- Phytochemistry and Biological Activities
- Ethnobotanical and Medicinal Plants Studies
- Pharmacological Effects of Natural Compounds
- Hydrogels: synthesis, properties, applications
- Attention Deficit Hyperactivity Disorder
- Natural Antidiabetic Agents Studies
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Cancer Treatment and Pharmacology
- Synthesis and biological activity
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Chemical Reaction Mechanisms
- Natural product bioactivities and synthesis
- Polysaccharides Composition and Applications
- Microtubule and mitosis dynamics
- Berberine and alkaloids research
- Medicinal Plants and Bioactive Compounds
- Bioactive Compounds and Antitumor Agents
- COVID-19 Clinical Research Studies
- Bioactive natural compounds
- Essential Oils and Antimicrobial Activity
- Diverse Scientific Research Studies
- Enzyme function and inhibition
Amity University
2016-2024
Noida International University
2018
Amity University
2016
Centre of Biomedical Research
2011
Ambedkar University Delhi
2006-2009
University of Delhi
2006-2009
Noscapine, the tubulin-binding anticancer agent, when administered orally, requires high ED(50) (300-600 mg/kg), whereas intravenous administration (10 mg/kg) results in rapid elimination of drug with a half-life 0.39 h. Hence, development long-circulating injectable nanoparticles can be an interesting option for designing viable formulation noscapine activity. Noscapine-enveloped gelatin and poly(ethylene glycol)-grafted were constructed characterized. Data indicate that smooth spherical...
In present investigation, an attempt was undertaken to modify the C-9 position of noscapine (Nos), opium alkaloid yield 9 -hydroxy methyl and -carbaldehyde oxime analogues for augmenting anticancer potential. The synthesis 9-hydroxy analogue Nos carried out by Blanc reaction 9-carbaldehyde engineered formation method characterized using FT-IR, 1H NMR, 13C mass spectroscopy, so on techniques. silico docking techniques informed that had higher binding energy score as compared Nos. IC50...
(S)-3-((R)-9-bromo-4-methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquino-lin-5-yl)-6,7-dimethoxyisobenzofuran-1(3H)-one (EM011) is a tubulin-binding agent with significant anticancer activity. Here we show that EM011 modulates microtubule dynamics at concentrations do not alter the total polymer mass of tubulin. In particular, decreases transition frequencies between growth and shortening phases increases duration microtubules spend in an idle 'pause' state. Using B16LS9 murine...
The medical values of garlic, a traditionally used allium vegetable, were recognized as early 3000 BC. Allicin, one the major organosulfur compounds present in is associated with wide variety benificial activities like anticancer, anti-inflammatory, antiarthritic, antimicrobial, anti-diabetic, cholesterol-lowering, potential to lower cardiovascular disorders, ameliorating neuron functions, etc. In this article, we have reviewed biological allicin and related since year 2010, using various...
2-methyl benzimidazole is a heterocyclic organic compound having an important pharmacophoric group which used in medicinal industry. o- Phenyldiamine was treated with acid the presence of polyphosphoric and other solvents. The specific determined by FTIR spectroscopy. obtaining screened antioxidant activity using DPPH method. Key words- 2- methyl benzimidazole, phenyldiamine, activity,
Background: Pentacyclic triterpenoids are a biologically active class of phytoconstituents with diverse pharmacological activities, including anti-inflammatory action. : In the current study, we isolated 3-Acetylmyricadiol, pentacyclic triterpenoid, from ethyl acetate bark extract Myrica esculenta and evaluated it for potential. Methods: The M. was subjected to column chromatography isolate 3-Acetylmyricadiol. MTT assay performed check cell viability. production proinflammatory mediators...
Abstract Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental with complex aetiology and phenotypes. Phosphodiesterase10A (PDE10A) has been shown to provide benefits in various brain conditions. We investigated the role of papaverine, selective PDE10A inhibitor on core phenotypes prenatal alcohol exposure (PAE) model ADHD. In order identify probable mechanisms involved, effects several protein markers neuronal function such as, survival‐BDNF, transcription factor‐pCREB,...
The present investigation emphasizes the pharmacognostic and phytochemical screening of Eulaliopsis binata further evaluates extracts this plant for toxicological profile anti-bacterial potential based on in vivo/in vitro assays. Microscopy, powder characteristics leaf material, physicochemical were assessed evaluation. Dry leaves extracted using different solvents (methanol, ethyl acetate, hexane), obtained investigated vitro/in vivo study. Moreover, acute toxicity was by evaluating...
Low therapeutic efficacy and drug-induced systemic toxicity of currently used anti-cancerous chemotherapeutic agents are major compelling factors for finding out clinically efficient molecules with high efficiency less toxicity.The current research work was undertaken to evaluate the anticancer potential Myricanol- 9-acetate (MA), a novel naturally occurring derivative myricanol.MCF-7, MiaPaCa-2, HCT 116 were cytotoxicity determination MA ML (Myricanol) by MTT assay. The mechanistic study...