A5037078581- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- IL-33, ST2, and ILC Pathways
- Chronic Myeloid Leukemia Treatments
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Renal and related cancers
- Whipple's Disease and Interleukins
- Mycobacterium research and diagnosis
- Lymphoma Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Mast cells and histamine
- Blood disorders and treatments
- Hematopoietic Stem Cell Transplantation
- Autoimmune and Inflammatory Disorders Research
University College London Hospitals NHS Foundation Trust
2019-2025
University College London
2003-2025
Royal Free London NHS Foundation Trust
2022-2025
Royal London Hospital
1999-2025
University of Oxford
2018-2025
National Institutes of Health
2009-2024
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2010-2024
University College Hospital
1999-2023
The Royal Free Hospital
2023
National Hospital for Neurology and Neurosurgery
1999-2022
Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement skin and bone.We studied nine children from six families who had neonatal onset sterile multifocal osteomyelitis, periostitis, pustulosis. Response to empirical treatment recombinant antagonist anakinra in first patient prompted us test...
Suppressor of cytokine signaling (Socs) 3 is a cytokine-inducible inhibitor with critical but selective cell-specific effects. We show that deficiency Socs3 in T cells had minimal effects on differentiation to the helper (Th) 1 or Th2 subsets; accordingly, no effect IL-12-dependent signal transducer and activator transcription (Stat) 4 phosphorylation IL-4-dependent Stat6 phosphorylation. By contrast, was found be major regulator IL-23-mediated Stat3 Th17 generation, directly binds IL-17A...
CD4(+) helper T cells can differentiate into several possible fates including: Th1, Th2, regulatory, and Th17 cells. Although, cytokine production by non-T is an important factor in cell differentiation, a characteristic feature of both Th1 Th2 lineages their ability to secrete cytokines that promote respective differentiation. However, produced help sustain have not yet been identified. Here we show IL-21 product cells, which induced Stat3-dependent manner. Additionally, Stat3 directly bind...
Interleukin-17 (IL-17)-producing T helper cells have been proposed to represent a separate lineage of CD4+ cells, designated Th17 which are regulated by the transcription factor retinoic acid-related orphan receptor gammat (RORgammat). However, despite advances in understanding murine differentiation, systematic assessment factors that promote differentiation naive human has not reported. The present study was undertaken assess effects on cytokines known cells.
Stimulation of naive mouse CD4(+)Foxp3(-) T cells in the presence TGF-β results induction Foxp3 expression and suppressor function. However, these induced regulatory (iTreg) is unstable, raising possibility that iTreg would not be useful for treatment autoimmune diseases. To analyze factors control stability iTreg, we generated OVA-specific from OT-II Foxp3-GFP knockin mice. Following transfer to normal C57BL/6 mice, GFP(+) maintained high levels 8 d. they rapidly lost upon stimulation with...
Objective There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit an aqueous extract Trametes robinophila Murr (Huaier granule) to address this unmet need. Design and results A total 1044 patients were randomised in 2:1 ratio receive either Huaier no further treatment (controls) for maximum...
Macrophages perform key functions in tissue homeostasis that are influenced by the local environment. Within tumor microenvironment, tumor-associated macrophages can be altered to acquire properties enhance growth. Here, we found lactate, a metabolite high concentration within anaerobic environment, activated mTORC1 subsequently suppressed TFEB-mediated expression of macrophage-specific vacuolar ATPase subunit ATP6V0d2. Atp6v0d2-/- mice were more susceptible growth, with enhanced...