A5100765157- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Nanoplatforms for cancer theranostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Hepatitis B Virus Studies
- Cancer, Lipids, and Metabolism
- Hepatitis C virus research
- Cancer Mechanisms and Therapy
- Advanced biosensing and bioanalysis techniques
- Photonic Crystals and Applications
- Ferroptosis and cancer prognosis
- Photonic and Optical Devices
- Plasmonic and Surface Plasmon Research
- MicroRNA in disease regulation
- Radiomics and Machine Learning in Medical Imaging
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Advanced Nanomaterials in Catalysis
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
Mengchao Hepatobiliary Hospital
2016-2025
Fujian Medical University
2016-2025
Fujian Provincial Cancer Hospital
2007-2025
Sichuan University
2019-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022-2024
Chinese Academy of Sciences
2008-2024
Changchun Institute of Applied Chemistry
2011-2024
Peking University Shenzhen Hospital
2022-2024
Shenzhen Institutes of Advanced Technology
2024
Fuzhou University
2014-2024
We assessed the efficacy and safety of camrelizumab [an anti-programmed death (PD-1) mAb] plus apatinib (a VEGFR-2 tyrosine kinase inhibitor) in patients with advanced hepatocellular carcinoma (HCC).This nonrandomized, open-label, multicenter, phase II study enrolled HCC who were treatment-naïve or refractory/intolerant to first-line targeted therapy. Patients received intravenous 200 mg (for bodyweight ≥50 kg) 3 mg/kg <50 every 2 weeks oral 250 daily. The primary endpoint was objective...
Photodynamic therapy (PDT), using a combination of chemical photosensitizers (PS) and light, has been successfully applied as noninvasive therapeutic procedure to treat tumors by inducing apoptosis or necrosis cancer cells. However, most current clinically used PS have suffered from the instability in physiological conditions which lead low photodynamic efficacy. Herein, highly biocompatible poly(dopamine) (PDA) nanoparticle conjugated with Chlorin e6 (referenced PDA-Ce6 nanosphere) was...
A near-infrared light-activated ratiometric photoelectrochemical aptasensor was fabricated for detection of carcinoembryonic antigen (CEA) coupling with upconversion nanoparticles (UCNPs)-semiconductor nanocrystals-based spatial-resolved technique on a homemade 3D printing device in which self-regulating integrated electrode designed dual signal readout. The as-prepared NaYF4:Yb,Er UCNPs@CdTe nanocrystals were initially assembled two adjacent photoelectrodes, then CEA aptamer 1 (A1) and...
Circular RNA (circRNA) possesses great pre-clinical diagnostic and therapeutic potentials in multiple cancers.It has been reported playing roles malignant behaviors including proliferation, migration, metastasis chemoresistance.However, the underlying correlation between circRNAs cancer stem cells (CSCs) not yet.Methods: circZKSCAN1 level was detected HCC tissue microarrays to clarify its prognostic values.Gain loss function experiments were applied investigate role of stemness.Bioinformatic...
Objective There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit an aqueous extract Trametes robinophila Murr (Huaier granule) to address this unmet need. Design and results A total 1044 patients were randomised in 2:1 ratio receive either Huaier no further treatment (controls) for maximum...
Abstract Anisotropic pressure sensors are gaining increasing attention for next‐generation wearable electronics and intelligent infrastructure owing to their sensitivity in identifying different directional forces. 3D printing technologies have unparalleled advantages the design of anisotropic with customized structures realizing tunable anisotropy. has demonstrated few successes utilizing piezoelectric nanocomposites recognition. However, 3D‐printed piezoresistive (PPSs) remain unexplored...
Abstract Cancer immunotherapy harnesses the body’s immune system to combat malignancies, building upon an understanding of tumor immunosurveillance and evasion mechanisms. This therapeutic approach reactivates anti-tumor responses can be categorized into active, passive, combined immunization strategies. Active engages recognize attack cells by leveraging host immunity with cytokine supplementation or vaccination. Conversely, passive employs exogenous agents, such as monoclonal antibodies...
In this paper, a core–shell nanocomposite of clusters superparamagnetic iron oxide nanoparticles coated with poly(dopamine) (SPION clusters@PDA) is fabricated as magnetic field-directed theranostic agent that combines the capabilities highly sensitive resonance imaging (MRI) and photothermal cancer therapy. The concentrated SPION cluster core suitable for MRI due to its properties, coating layer can induce cell death under near-infrared (NIR) laser irradiation because conversion ability PDA....
Tumor microenvironment responsive multimodal synergistic theranostic strategies can significantly improve the therapeutic efficacy while avoiding severe side effects. Inspired by fact that special morphology could enhance photothermal conversion efficiency (PCE) and cellular delivery, we developed an acidic tumor shape-reversal metal–organic virus-inspired nanodrug for enhancing near-infrared (NIR)-II PCE, increasing cell adhesion, activating targeting. First, a NIR-I fluorescence probe...
Circulating tumor DNA (ctDNA) provides a novel approach for detecting burden and predicting clinical outcomes of hepatocellular carcinoma (HCC). Here, we performed thorough evaluation HCC circulating genetic features further fully integrated them to build robust strategy monitoring prognostic outcome assessment.We target sequencing low-coverage whole-genome on plasma samples collected from 34 long-term follow-up patients with capture somatic SNVs CNVs, respectively. Clinical information was...
The therapeutic efficacy of fluorescence image-guided tumor surgery and photodynamic therapy (PDT) is impaired by the penetration depth limitation, low signal-to-noise ratio traditional first near-infrared window (NIR I) hypoxic microenvironment. Here, a "red blood cell-based multimodal probe" was proposed to achieve enhanced targeting retention fluorescent probes after an intravenous injection, so that second II) bioimaging-guided complete resection high-efficiency could then be realized....
Abstract Background Adipose tissue-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative medicine. However, long-term in vitro passaging leads to stemness loss and cell senescence of ADSCs, resulting failure ADSC-based therapy. Methods In this study, ADSCs were treated with low dose antioxidants (reduced glutathione melatonin) anti-aging protection properties the passaging, functions including senescence, migration, multidirectional differentiation potential, ROS...
Circular RNA (circRNA) can participate in various biological processes, including tumorigenesis, through their microRNA response elements. Alterations circRNA profiles during hepatocellular carcinoma (HCC) progression and clinical significance remain unclear. Here, we present extensive analysis of tumor matched peritumor tissues collected from 10 HCC patients, conducted to identify related progression. A total 42 dysregulated (38 down-regulated 4 up-regulated) were identified compared with...
Efficient and cancer cell-targeted delivery of photosensitizer (PS) therapeutic protein has great potentiality for improving the anticancer effects. Herein, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, one most attractive metal–organic framework materials, were used coencapsulating chlorin e6 (Ce6, a potent PS) cytochrome c (Cyt c, apoptosis inducer); then nanoparticle was subsequently decorated with hyaluronic acid (HA) shell to form cell-active targeted nanoplatform (Ce6/Cyt...
Plexcitonic strong coupling between a plasmon-polariton and quantum emitter empowers ultrafast manipulations in the nanoscale under ambient conditions. The main body of previous studies deals with homogeneous emitters. To enable multiqubit states for future computing network, involving two excitons same material but different resonant energies has been investigated observed primarily at very low temperature. Here, we report room-temperature diexcitonic (DiSC) nanosystem which transition...
Abstract Piezoelectric energy harvesters (PEHs) have attracted great attention owing to the capability of converting various forms mechanical into electricity. Traditional approaches for improving piezoelectric conversion efficiency usually involve either complicated composite preparation or significant compromise in device's strength and measure, which obviously cannot fulfill stringent requirements power supplies within miniaturized footprint on compliance modern electronics. Herein, an...
Piezoelectric pressure sensors are important for applications in robotics, artificial intelligence, communication devices, etc. The hyperboloid is theoretically predicted to be an unusual 3D structure that allows concerted piezoelectric enhancement owing its synergistic effects of geometrical stress confinement and concentration, but has not been experimentally fulfilled due a lack efficient architecting techniques. In this work, hyperboloidal arrayed self-polarized PVDF energy harvester...
Early diagnosis of hepatocellular carcinoma (HCC) lacks highly sensitive and specific protein biomarkers. Here, we describe a staged mass spectrometry (MS)-based discovery-verification-validation proteomics workflow to explore serum proteomic biomarkers for HCC early in 1002 individuals. Machine learning model determined as P4 panel (HABP2, CD163, AFP PIVKA-II) clearly distinguish from liver cirrhosis (LC, AUC 0.979, sensitivity 0.925, specificity 0.915) healthy individuals (HC, 0.992,...