A5000211630- Cancer-related molecular mechanisms research
- Asthma and respiratory diseases
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Drug-Induced Adverse Reactions
- Inflammasome and immune disorders
- Ocular Diseases and Behçet’s Syndrome
- RNA modifications and cancer
- Dermatology and Skin Diseases
- Sphingolipid Metabolism and Signaling
- Urticaria and Related Conditions
- Systemic Lupus Erythematosus Research
- Circular RNAs in diseases
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- RNA Research and Splicing
- Signaling Pathways in Disease
- Lysosomal Storage Disorders Research
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Pharmacovigilance and Adverse Drug Reactions
- Mast cells and histamine
- Allergic Rhinitis and Sensitization
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
Brigham and Women's Hospital
2019-2024
Harvard University
2019-2024
Boston Children's Hospital
2024
Texas Tech University Health Sciences Center
2016-2023
Ribon Therapeutics (United States)
2023
Texas Tech University
2016-2022
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2009-2021
Office of Science
2010-2021
Albany Medical Center Hospital
2018-2019
AstraZeneca (United States)
2013
Autoinflammatory diseases manifest inflammation without evidence of infection, high-titer autoantibodies, or autoreactive T cells. We report a disorder caused by mutations IL1RN, which encodes the interleukin-1-receptor antagonist, with prominent involvement skin and bone.We studied nine children from six families who had neonatal onset sterile multifocal osteomyelitis, periostitis, pustulosis. Response to empirical treatment recombinant antagonist anakinra in first patient prompted us test...
Monogenic autoinflammatory diseases are disorders of Mendelian inheritance that characterized by mutations in genes regulate innate immunity and whose typical features systemic inflammation without high-titer autoantibodies or antigen-specific T cells. Skin bone the newborn period have been described 3 these disorders: neonatal-onset multisystem inflammatory disease, Majeed syndrome, deficiency interleukin-1 (IL-1) receptor antagonist (DIRA) syndrome. This study was undertaken to present...
Background: Parkinson's disease (PD) and multiple system atrophy (MSA) patients often suffer from gastrointestinal (GI) dysfunction GI dysbiosis (microbial imbalance).GI also occurs in mouse models of PD MSA.Objectives: To assess gut subjects as compared to controls, identify potential shared microbial taxa humans MSA, the effects therapies on microbiota.Methods: In this human pilot study, function was assessed by fecal consistency/frequency measured using Bristol Stool Form Scale transit...
Highlights•GM2+/− mice, with reduced GM1 levels, develop age-onset parkinsonian symptoms.•Reduced levels increase GM2+/− synucleinopathy and loss of myelin markers.•Low dose FTY720 reduces in the nervous system.•Low increases BDNF markers mice.•Movement bladder function are improved by low mice.AbstractParkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies urgently needed. PD pathology includes α-synuclein (aSyn)...
The authors have nothing to disclose.
Multiple system atrophy (MSA) is a fatal disorder with no effective treatment. MSA pathology characterized by α-synuclein (aSyn) accumulation in oligodendrocytes, the myelinating glial cells of central nervous (CNS). aSyn oligodendrocytes forms pathognomonic cytoplasmic inclusions (GCIs) MSA. also associated motor and autonomic dysfunction, including an impaired ability to sweat. patients have abnormal CNS expression glial-cell-line-derived neurotrophic factor (GDNF) brain-derived (BDNF)....
Since the last publication of this medical algorithm in 2020,1 our definition biologicals has expanded from meaning only monoclonal antibodies (mAbs) to mean drugs made organic molecules that are produced exclusively by living organisms and specifically target a gene or protein for therapy.2 Within broader included exogenous hormones (e.g., insulin levothyroxine), modern vaccines mRNA SARS-CoV-2 vaccines), nanobodies calplacizumab, an FDA-approved therapy acquired thrombotic thrombocytopenic...
Parkinson's disease (PD) is a neurodegenerative aging disorder in which postmortem PD brain exhibits neuroinflammation, as well synucleinopathy-associated protein phosphatase 2A (PP2A) enzymatic activity loss. Based on our translational research, we began evaluating the PD-repurposing-potential of an anti-inflammatory, neuroprotective, and PP2A stimulatory oral drug that FDA-approved for multiple sclerosis, FTY720 (fingolimod, Gilenya®). We also designed two new analogues, FTY720-C2...
Inflammatory processes resulting from the secretion of soluble mediators by immune cells, lead to various manifestations in skin, joints and other tissues as well altered cytokine homeostasis. The innate system plays a crucial role recognizing pathogens endogenous danger stimuli. One major cytokines released cells is Interleukin (IL)-1. Therefore, we utilize whole blood stimulation assay order measure inflammatory specifically pro-inflammatory IL-1β 1, 2, 3. Patients with genetic...
Abstract Zinc Finger transcription factors are crucial in modulating various cellular processes, including differentiation. Chromatin reader MYND (Myeloid, Nervy, and DEAF-1) type containing 8 (ZMYND8), an All-Trans Retinoic Acid (ATRA)-responsive gene, was previously shown to play a role promoting the expression of neuronal-lineage committed genes. Here, we report that ZMYND8 promotes neuronal differentiation by positively regulating canonical MAPT protein-coding gene isoform, key player...