A5056738571- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Gallbladder and Bile Duct Disorders
- Antibiotic Resistance in Bacteria
- Connexins and lens biology
- Immunotherapy and Immune Responses
- Cholangiocarcinoma and Gallbladder Cancer Studies
- DNA Repair Mechanisms
- Nanoparticle-Based Drug Delivery
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- Biochemical effects in animals
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Protein Hydrolysis and Bioactive Peptides
- Pancreatitis Pathology and Treatment
- Heat shock proteins research
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
Jilin Agricultural University
2022-2025
Shenyang Pharmaceutical University
2018-2024
Institute of Hematology & Blood Diseases Hospital
2019-2024
China University of Petroleum, East China
2023-2024
Nanchang University
2024
Tiangong University
2024
Wuhan University
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
China Pharmaceutical University
2023
Zhejiang University
2023
Objective There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit an aqueous extract Trametes robinophila Murr (Huaier granule) to address this unmet need. Design and results A total 1044 patients were randomised in 2:1 ratio receive either Huaier no further treatment (controls) for maximum...
Aiming to solve the trade-off of "room-temperature phosphorescence (RTP)-flexibility" in principle, organic RTP crystals with elastic/plastic deformation are realized. These properties mainly due divisional aggregation structures aromatics and alkoxy chains, can be modulated by controllable molecular configurations. The longest lifetime 972.3 ms is achieved as highest record for flexible crystals. Plastic persistent realized, which applied into biomedical optical technologies afterglow...
Innate lymphoid cells (ILC) are part of a heterogeneous family haematopoietic effector which lack re-arranged antigen-specific receptors. They promote host defense and contribute to tissue metabolic homeostasis, wound healing immune surveillance. Their role in human cancer immunity is less defined, therefore we aimed identify the frequency phenotype distinct ILC groups various types cancer.Tissue samples peripheral blood were collected from patients undergoing surgical resection...
Autophagy flux plays a significant protective role in type 2 diabetes mellitus (T2DM). However, the mechanisms by which autophagy mediates insulin resistance (IR) to ameliorate T2DM remain unclear. This study explored hypoglycemic effects and of walnut-derived peptides (fraction 3-10 kDa LP5) streptozotocin high-fat-diet-induced mice. Findings revealed that reduced levels blood glucose FINS ameliorated IR dyslipidemia. They also increased SOD GSH-PX activities inhibited secretion TNF-α,...
Abstract Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity tumor microenvironment. Expression HLA-E is linked to poor clinical outcomes mice and human patients. However, contributions immune evasion HLA-E, a ligand for inhibitory CD94/NKG2A receptor, when expressed on tumors, compared adjacent tissue peripheral blood mononuclear cells, remains unclear. In this study, we report that epithelial-derived macrophages,...
Background: Cancer patients often display dysfunctional anti-tumor T cell responses. Since noteworthy benefits of immune checkpoint pathway blockade, such as PD-1 inhibitors, have been achieved in multiple advanced cancers, the next critical question is which mono- or combinatorial blockade regimens may reinvigorate immunity those cancer while limiting immune-related adverse effects. Method: This study recruited, total, 172 primary (131 were blood-tumor matched patients) who treatment-naïve...
Long noncoding RNA (lncRNA) small nucleolar host gene 16 (SNHG16) has been linked to multiple cancers including breast, ovarian, bladder, and colorectal cancer. However, the role of SNHG16 in cervical cancer is unclear. Here, quantitative analysis PARP9 expression levels tissues cell lines indicated that both were highly expressed compared with controls. Using dual-luciferase reporter assay, immunoprecipitation, chromatin we able determine recruited SPI1 protein promote transcription...
This study aimed to investigate the anti-inflammatory effect of walnut-derived peptide LPLLR (LP-5) in oxidative stress-induced Caco-2 cells and model mice. The results showed that LP-5 significantly increased activities CAT SOD, while decreased levels MDA both vitro vivo. stress signaling was regulated by promoting Nrf2 nuclear transfer, up-regulating HO-1 expression, down-regulating Keap1 expression. As demonstrated molecular docking, could effectively bind Keap1. Additionally, inhibited...
The self-assembly prodrugs are usually consisted of drug modules, activation and assembly modules. Keeping the balance between efficacy safety by selecting suitable modules remains a challenge for developing prodrug nanoassemblies. This study designed four docetaxel (DTX) using disulfide bonds as different lengths branched-chain fatty alcohols (C16, C18, C20, C24). determined ability affected modules' sensitivity. extension carbon chains improved prodrugs' pharmacokinetic behavior while...
A major challenge in the treatment of pancreatic ductal adenocarcinoma is failure chemotherapy, which likely due to presence cancer stem cells (CSCs).To identify side population (SP) and characterize s-like properties human cell lines (h-PCCLs) exploit efficacy concomitant targeting multiple key transcription factors governing stemness CSCs suppressing CSC-like phenotypes.Flow cytometry Hoechst 33342 DNA-binding dye efflux assay were used sort SP non-SP (NSP) from three h-PCCLs: PANC-1,...
Abnormal expression or distribution of connexin 32 (Cx32) is associated with hepatocarcinogenesis, but the role Cx32 and underlying mechanisms are still unclear.The level in 96 hepatocellular carcinoma (HCC) specimens was determined using western blotting immunohistochemistry. The correlation between clinicopathological parameters analyzed. cell apoptosis rate examined flow cytometry blotting. Src kinase epidermal growth factor receptor (EGFR) signaling pathways measured by quantitative...
MicroRNA is expected to be a novel therapeutic tool for tumors. Gap junctions facilitate the transfer of microRNA, which exerts biological effects on tumor cells. However, length microRNA that can pass through certain gap composed specific connexin remains unknown. To address this question, present study investigated permeability various connexins, including 43, 32 or 37, microRNAs consisting 18-27 nucleotides in glioma cells and cervical cancer Results indicated all were able transferred...
The disulfide bond plays a crucial role in the design of anti-tumor prodrugs due to its exceptional tumor-specific redox responsiveness. However, premature breaking bonds is triggered by small amounts reducing substances (e.g., ascorbic acid, glutathione, uric acid and tea polyphenols) systemic circulation. This may lead toxicity, particularly oral that require more frequent high-dose treatments. Fine-tuning activation kinetics these promising prospect for efficient on-target cancer...
The critical roles of sortase A (SrtA) and listeriolysin O (LLO) in Listeria monocytogenes pathogenicity render these two virulence factors as ideal targets for the development anti-virulence agents against L. infection. Additionally, structures SrtA LLO are highly conserved among members enzyme family cholesterol dependent toxin family. Here, phloretin, a natural polyphenolic compound derived from apples pears that has little anti-L. activity, was identified to simultaneously inhibit...
Octamer‑binding transcription factor 4 (OCT4) is one of the factors associated with self‑renewal and differentiation in cancer stem cells, crucial for progression various types human malignancy. However, expression function OCT4 pancreatic has not been fully elucidated. The purpose present study was to investigate molecular mechanisms cells. clinical significance assessed by an immunohistochemical assay using a tissue microarray procedure tissues cells different degrees differentiation. A...
The objective of the present study was to investigate and analyze epithelial‑cadherin (E‑cadherin) expression in invasive ductal carcinoma breast, associations between clinicopathological characteristics lymph node metastasis prognosis breast cancer. immunohistochemical streptavidin‑peroxidase method used detect E‑cadherin 30 cases fibroadenoma 450 cancer, then χ2 test Kaplan‑Meier were data. showed positive E‑cadherin. Specifically, results found that highly expressed 49.04% (77/157)...