A5025189497- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Health Systems, Economic Evaluations, Quality of Life
- Virology and Viral Diseases
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- COVID-19 epidemiological studies
- Viral Infections and Immunology Research
- Pharmaceutical Economics and Policy
- Nanoplatforms for cancer theranostics
- Substance Abuse Treatment and Outcomes
- Health Promotion and Cardiovascular Prevention
- vaccines and immunoinformatics approaches
- Pharmaceutical studies and practices
- Pregnancy and Medication Impact
- Chronic Disease Management Strategies
- Health Policy Implementation Science
- Bone health and treatments
- Multiple Myeloma Research and Treatments
- COVID-19 Impact on Reproduction
University of Oxford
2019-2024
MRC Weatherall Institute of Molecular Medicine
2011-2024
Public Health Scotland
2020-2021
National Health Service Scotland
2013-2020
NHS Lothian
2017-2019
National Health Service
2018
Nurse-Family Partnership
2017
Medical Research Council
2011
MRC Human Immunology Unit
2011
Abstract NP 105–113 -B*07:02-specific CD8 + T cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis clones and single-cell sequencing were performed concurrently, functional avidity antiviral efficacy assessed using an vitro SARS-CoV-2 infection system, correlated receptor usage, transcriptome signature disease severity (acute n = 77, convalescent 52). demonstrated a beneficial cells...
Abstract Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity tumor microenvironment. Expression HLA-E is linked to poor clinical outcomes mice and human patients. However, contributions immune evasion HLA-E, a ligand for inhibitory CD94/NKG2A receptor, when expressed on tumors, compared adjacent tissue peripheral blood mononuclear cells, remains unclear. In this study, we report that epithelial-derived macrophages,...
Background: Cancer patients often display dysfunctional anti-tumor T cell responses. Since noteworthy benefits of immune checkpoint pathway blockade, such as PD-1 inhibitors, have been achieved in multiple advanced cancers, the next critical question is which mono- or combinatorial blockade regimens may reinvigorate immunity those cancer while limiting immune-related adverse effects. Method: This study recruited, total, 172 primary (131 were blood-tumor matched patients) who treatment-naïve...
Abstract Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts homeostasis causing skeletal damage and pain. Mechanisms underlying myeloma-induced destruction are poorly understood current therapies do not restore lost mass. Using transcriptomic profiling of isolated lining cell subtypes from a murine model, we find morphogenetic protein (BMP) signalling upregulated in stromal progenitor cells. BMP has previously been reported to be dysregulated disease. Inhibition...
Surveys suggest most people would prefer to die in their own home.To examine predictors of place death over an 11-year period between 2000 and 2010 Dumfries Galloway, south west Scotland.Retrospective cohort study.19,697 Galloway residents who died the region or elsewhere Scotland. We explored relation age, gender, cause (cancer, respiratory, ischaemic heart disease, stroke dementia) (acute hospital, cottage residential care home) using regression models show differences trends. The main...
Enrichment of CD103
Abstract Cancer remains one of the leading causes mortality worldwide, to increased interest in utilizing immunotherapy strategies for better cancer treatments. In past decade, CD103 + T cells have been associated with clinical prognosis patients cancer. However, specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear. Here, we show an unexpected and transient CD61 expression, which is paired at synaptic microclusters cells. colocalization cell...
The Mexican healthcare system is under increasing strain due to the rising prevalence of non-communicable diseases (especially type 2 diabetes), mounting costs, and a reactive curative approach focused on treating existing their complications rather than preventing them. Casalud comprehensive primary model that enables proactive prevention disease management throughout continuum care, using innovative technologies patient-centred approach. Data were collected over 2-year period in eight...
Abstract In September 2016, an imported case of measles in Edinburgh a university student resulted further 17 confirmed cases during October and November 2016. All were genotype D8 associated with virus strain most commonly seen South East Asia. Twelve the 18 staff or students at had incomplete unknown mumps rubella (MMR) vaccination status. The public health response included mass follow-up all identified contacts, widespread communications throughout universities prompt clinics affected...
Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTL), and a surrogate marker for detection antigen-specific cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression production upon activation. Assessing the relationship between 5'methylcytosine-guanine (CpG) dinucleotide methylation promoter using bisulphite treatment shown IFNγ- accumulates CpG hypermethylation within at key transcription factor binding sites (-186 -54), known to...
Most existing studies characterizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses are peptide based. This does not allow evaluation of whether tested peptides processed and presented canonically. In this study, we use recombinant vaccinia virus (rVACV)-mediated expression SARS-CoV-2 spike protein infection angiotensin-converting enzyme (ACE)-2-transduced B lines to evaluate overall in a small cohort recovered COVID-19 patients uninfected donors...
Abstract Little is known of the role cytotoxic CD4 + T-cells in control viral replication. Here, we investigate T-cell responses to three dominant SARS-CoV-2 epitopes and evaluate antiviral activity, including cytotoxicity cytokine production. Diverse T cell receptor (TCR) usage public TCRs were identified; surprisingly, found have signalling pathways distinct from classical CD8 T-cells, with increased expression chemokines tissue homing receptors promoting migration. We show presence...
Mexico, like many low- and middle-income countries (LMICs), faces an epidemic of chronic non-communicable diseases (NCDs), specifically diabetes, hypertension, obesity, lipid disorders. Many people with these NCDs may not be aware that they have a disease, pointing to the need for broader screening programs. The traditional prevention policy in Mexico was based on paper-based risk factor questionnaire. However, this used screen patients already seeking healthcare services at facilities,...
Abstract Another large outbreak of mumps occurred in Lothian from October 2017, which coincided with the commencement higher education term. During this period 324 cases were notified, most whom aged 18–22 years old. Although previous outbreaks had a focus student populations, 43% current reported that they not student. There has been increases private housing where students all universities live, may have contributed to wide spread and complicated control. Information on vaccination status...
IntroductionThe Scottish Medicines Consortium (SMC) provides advice about clinical- and cost-effectiveness of newly licensed medicines to the National Health Service (NHS) in Scotland. Since 2005, SMC has also provided early intelligence on developmentthrough "Forward Look" (FL) reports. An investigation was undertaken examine completeness FL its usefulness NHS Boards.Patients (or Materials) Methods(1) Significant (with potential for net budget impact exceeding UK£500,000 per annum at year 5...
Most existing studies characterising SARS-CoV-2-specific T cell responses are peptide based. This does not allow evaluation of whether tested peptides processed and presented canonically. In this study, we used recombinant vaccinia virus (rVACV)-mediated expression SARS-CoV-2 spike protein infection ACE-2-transduced B lines to evaluate overall in a small cohort recovered COVID-19 patients uninfected donors vaccinated with ChAdOx1 nCoV-19. We showed that rVACV antigen can be as an alternative...
<div>Abstract<p>Enrichment of CD103<sup>+</sup> tumor-infiltrating T lymphocytes (TIL) is associated with improved outcomes in patients. However, the characteristics human cytotoxic CD8<sup>+</sup> cells (CTL) and their role tumor control remain unclear. We investigated features antitumor mechanisms CTLs by assessing T-cell receptor (TCR)–matched CD103<sup>−</sup> cancer-specific CTL immunity <i>in vitro</i> its immunophenotype...
<div>Abstract<p>Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity tumor microenvironment. Expression HLA-E is linked to poor clinical outcomes mice and human patients. However, contributions immune evasion HLA-E, a ligand for inhibitory CD94/NKG2A receptor, when expressed on tumors, compared adjacent tissue peripheral blood mononuclear cells, remains unclear. In this study, we report that...
<div>Abstract<p>Enrichment of CD103<sup>+</sup> tumor-infiltrating T lymphocytes (TIL) is associated with improved outcomes in patients. However, the characteristics human cytotoxic CD8<sup>+</sup> cells (CTL) and their role tumor control remain unclear. We investigated features antitumor mechanisms CTLs by assessing T-cell receptor (TCR)–matched CD103<sup>−</sup> cancer-specific CTL immunity <i>in vitro</i> its immunophenotype...
<div>Abstract<p>Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity tumor microenvironment. Expression HLA-E is linked to poor clinical outcomes mice and human patients. However, contributions immune evasion HLA-E, a ligand for inhibitory CD94/NKG2A receptor, when expressed on tumors, compared adjacent tissue peripheral blood mononuclear cells, remains unclear. In this study, we report that...