A5100558199- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Iron and Steelmaking Processes
- Microscopic Colitis
- Advanced Sensor and Energy Harvesting Materials
- Industrial Gas Emission Control
- Granular flow and fluidized beds
- Geometry and complex manifolds
- CRISPR and Genetic Engineering
- Immune cells in cancer
- Mineral Processing and Grinding
- Inflammatory Bowel Disease
- SARS-CoV-2 and COVID-19 Research
- Geometric Analysis and Curvature Flows
- Cyclone Separators and Fluid Dynamics
- Colorectal Cancer Treatments and Studies
- Geometric and Algebraic Topology
- Catalytic Processes in Materials Science
- Advanced Materials and Mechanics
- Thermal Analysis in Power Transmission
- Power Systems and Renewable Energy
- Aerospace Engineering and Energy Systems
- Hidradenitis Suppurativa and Treatments
Beijing Jiaotong University
2024-2025
Beijing University of Technology
2023-2025
Guangdong Pharmaceutical University
2025
Wuzhou University
2024
Army Medical University
2023-2024
AbbVie (United States)
2022-2024
Xi'an Jiaotong University
2024
Hubei University of Medicine
2024
Hochschule für Musik Freiburg
2024
Technological University of the Philippines
2024
Current DNA base editors contain nuclease and deaminase that enables deamination of cytosine (C) or adenine (A), but no method for guanine (G) thymine (T) editing is available at present. Here we developed a deaminase-free glycosylase-based editor (gGBE) with G ability, by fusing Cas9 nickase engineered N-methylpurine glycosylase protein (MPG). By several rounds MPG mutagenesis via unbiased rational screening using an intron-split EGFP reporter, demonstrated gGBE could increase efficiency...
Reactive oxygen burst in articular chondrocytes is a major contributor to osteoarthritis progression. Although selenium indispensable role the antioxidant process, narrow therapeutic window, delicate toxicity margins, and lack of an efficient delivery system have hindered its translation clinical applications. Herein, transcriptomic biochemical analyses revealed that was associated with metabolic abnormality. A novel injectable hydrogel deliver nanoparticles (SeNPs) proposed intervene...
DNA base editors enable direct editing of adenine (A), cytosine (C), or guanine (G), but there is no editor for thymine (T) currently. Here we develop two deaminase-free glycosylase-based T (gTBE) and C (gCBE) by fusing Cas9 nickase (nCas9) with engineered human uracil glycosylase (UNG) variants. By several rounds structure-informed rational mutagenesis on UNG in cultured cells, obtain gTBE gCBE high activity T-to-S (i.e., T-to-C T-to-G) C-to-G conversions, respectively. Furthermore, conduct...
Abstract The occurrence of peritendinous adhesion, which hampers the quality and function healed tendon, is strongly linked to oxidative stress, inflammatory, infection that occur after surgery. Tendon damage repair provide a considerable obstacle for regenerative medicine owing absence patches possess comprehensive functionality, including self‐healing capacity, anti‐inflammatory anti‐bacterial properties, as well tissue guidance. A dual dynamic crosslinked network created by coordination...
Learning about the strain/stress distribution in a material is essential to achieve its mechanical stability and proper functionality. Conventional techniques such as universal testing machines only apply static samples with standardized geometry laboratory environment. Soft sensors based on stretchable conductors, carbon-filled composites, or conductive gels possess better adaptability, but still face challenges from complicated fabrication process, dependence extra readout device, limited...
The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has incurred devastating human and economic losses. Vaccination remains most effective approach for controlling COVID-19 pandemic. Nonetheless, sustained evolution of SARS-CoV-2 variants provoked concerns among scientific community regarding development next-generation vaccines. Among these, given their safety, immunogenicity, flexibility to display varied native...
Let $\Omega$ be a smooth, bounded domain in $\mathbb R^3$ with connected boundary. It follows from work of Escobar that the Yamabe quotient is at most ball, and equality holds if only ball. We show almost then following things are true: (i)$\Omega$ diffeomorphic to ball; (ii) There small number $\epsilon > 0$ such $B(x,r) \subset \Omega B(x,r(1+\epsilon))$; (iii) After suitable scaling, Gromov-Hausdorff close unit ball when considered as metric space its induced length metric. also give...
Runchangningshen paste (RCNSP) is a made of four medicinal and edible homologous Chinese medicine mixed with honey. It known for its ability to nourish yin blood as well loosen the bowel relieve constipation. The pathophysiology functional constipation (FC) associated reduction in mucin-2 (MUC2) secretion microbial dysbiosis. To investigate underlying mechanism RCNSP against FC through MUC2 gut mucosal microbiota. Ultra-performance liquid chromatography tandem mass spectrometry characterized...
Abstract Since respiration responds to many health conditions, it is essential monitor respiratory signals by constant humidity changes. Herein, a strategy for continuous, wireless, non‐invasive monitoring proposed using wireless energy storage and sensing integrated device (WES‐HSID), which includes charging coil (WCC), micro‐supercapacitors (MSCs) sensor. All electrodes of functional units are prepared all‐in‐one material, exhibits high conductivity (3 Ω cm −2 WCC sensor electrodes)...
Swelling positively in water is a common behavior of hydrogels, which, however, can lead to reduced mechanical performance and stability. Enabling negative swelling represents promising way address those issues but extremely challenging realize. Here, real hydrogels are successfully prepared for the first time through unique molecular architecture. Specifically designed interpenetrating transformable-rigid polymer network undergoes self-assembly collapses upon hydration, which turn...
The longitudinal altitude and airspeed coordinated control is critical for unmanned fixed-wing aircrafts, especially during the taxiing landing process However, due to strongly coupled relation of kinetic energy gravitational potential energy, precision difficult. traditional method based on PID (Proportional Integral-Differential) usually adopts different parameters at flight stages. But regulation structure complex, some fluctuation may exist transition process, which will affect...
In this paper, the flow behavior of gas−solid in standpipe a circulating fluidized bed (CFB) and its influence on system pressure balance hydrodynamic performance have been studied. A CFB apparatus with square riser 0.1 × m cross-section 4.5 height 3.0 0.08 diameter were established. The connected to loop seal one end cyclone other end. experimental results showed that is not only strongly related particle holdup, structure, aeration rate but also coupled drops rest parts system. At...
Osteoarthritis (OA) is a progressive degenerative joint sickness related with mechanics, obesity, ageing, etc., mainly characterized by cartilage degeneration, subchondral bone damage and synovium inflammation. Coordinated mechanical absorption conduction of the play significant roles in prevalence development OA. Subchondral generally considered load-burdening tissue where mechanosensitive cells are resident, including osteocytes, osteoblast lineage cells, osteoclast (especially less...
To assess the feasibility of clean air as an insulation medium in DC gas-insulated switchgear (GIS), surface charge accumulation, a recognized pivotal concern, was examined both within and SF <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> , employing real-sized insulator. The results indicate that speckles tend to manifest air, while uniform distributions observed gases seem quite similar. Evidently, at pressure 0.6 MPa is superior with...
Abstract Material design based on the assembly of functional units has demonstrated tremendous technical and commercial potential. Among others, polymers are identified to be an ideal building block due their abundant groups, high programmability, great biocompatibility. In this review, introducing recently developed advanced materials enabled by rationally designed polymer self‐assembly focussed. The working principle typical intermolecular interactions shape nano‐patterns structural...
We identify amino acid variants within dominant SARS-CoV-2 T-cell epitopes by interrogating global sequence data. Several nucleocapsid and ORF3a have arisen independently in multiple lineages result loss of recognition epitope-specific T-cells assessed IFN-γ cytotoxic killing assays. These data demonstrate the potential for evasion highlight need ongoing surveillance capable escaping as well humoral immunity.Funding: This work is supported UK Medical Research Council (MRC); Chinese Academy...
Shells of Castanea mollissima (CMS), an agricultural remain and often considered waste from chestnut processing industry, have been proven a resource for traditional Chinese medicine. One new phenol, named castanolB(1), andsix known phenolic compounds (2–7) were isolated froma water-soluble extract CMS. Their chemical structures determined using preparative HPLC various spectral analyses, then compared to literatures, which indicated the first identification seven C. mollissima. The...