A5056257417- Immunotherapy and Immune Responses
- AI in cancer detection
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Image Retrieval and Classification Techniques
- Advanced Image and Video Retrieval Techniques
- Radiomics and Machine Learning in Medical Imaging
- Immune Cell Function and Interaction
- Colorectal Cancer Screening and Detection
- Face and Expression Recognition
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Digital Imaging for Blood Diseases
- Immune cells in cancer
- Generative Adversarial Networks and Image Synthesis
- Phosphodiesterase function and regulation
- Remote-Sensing Image Classification
- Cloud Computing and Resource Management
- IoT and Edge/Fog Computing
- Neural Networks and Applications
- Retinal Development and Disorders
- Extracellular vesicles in disease
- Urologic and reproductive health conditions
- Distributed and Parallel Computing Systems
- Medical Imaging and Analysis
University of Oxford
2013-2025
Science Oxford
2024
John Radcliffe Hospital
2019-2024
Oxford BioMedica (United Kingdom)
2018-2021
Open Data Institute
2020
National Institute for Health Research
2019-2020
Institute of Biomedical Science
2019
Brunel University of London
2009-2012
Article28 July 2020Open Access Source DataTransparent process Glutamine deprivation alters the origin and function of cancer cell exosomes Shih-Jung Fan Department Physiology, Anatomy Genetics, University Oxford, UK Search for more papers by this author Benjamin Kroeger orcid.org/0000-0003-1479-3841 Pauline P Marie Esther M Bridges Oncology, Weatherall Institute Molecular Medicine, John D Mason Kristie McCormick Christos E Zois Helen Sheldon Nasullah Khalid Alham Biomedical Engineering,...
Research using whole slide images (WSIs) of histopathology slides has increased exponentially over recent years. Glass from retrospective cohorts, some with patient follow-up data are digitised for the development and validation artificial intelligence (AI) tools. Such resources, therefore, become very important, need to ensure that their quality is standard necessary downstream AI development. However, manual control large cohorts WSIs by visual assessment unfeasible, whilst algorithms...
Recently MapReduce programming model is becoming popular for large scale data intensive distributed applications due to its efficiency, simplicity and ease of use. The Hadoop implementation one the most tools many programmers ability hide details parallel from users. However work on simulating environment still in infancy. Although there are a number available simulate environments. only few simulators which specifically targets environment. Based testing we performed; usability these not...
Idiopathic pulmonary fibrosis (IPF) is the most severe form of chronic lung fibrosis. Circulating monocytes have been implicated in immune pathology IPF but their phenotype unknown. In this work, we determined using multi-colour flow cytometry, RNA sequencing and corresponding serum factors, mapped main findings to amount single cell transcriptomic landscape myeloid cells lungs. We show that from patients displayed increased expression CD64 (FcγR1) which correlated with fibrosis, an...
The success of checkpoint inhibitors (CPIs) for cancer has been tempered by immune-related adverse effects including colitis. CPI-induced colitis is hallmarked expansion resident mucosal IFNγ cytotoxic CD8+ T cells, but how these arise unclear. Here, we track CPI-bound cells in intestinal tissue using multimodal single-cell and subcellular spatial transcriptomics (ST). Target occupancy was increased inflamed tissue, with drug-bound located distinct microdomains distinguished specific...
Aims The Oxford Classification E score (endocapillary hypercellularity) predicts renal functional decline in IgA nephropathy (Ig AN ) patients free from steroid/immunosuppressive ( IS therapy, but is poorly reproducible. We hypothesise that endocapillary hypercellularity reflects glomerular inflammation and the presence of CD 68‐positive cells a more robust marker score. Methods results were quantified glomeruli tubulointerstitium biopsies 118 Ig patients, cell counts correlated with...
Testicular cancer is the most common in men aged from 15 to 34 years. Lymphovascular invasion refers presence of tumours within endothelial-lined lymphatic or vascular channels, and has been shown have prognostic significance testicular germ cell tumours. In non-seminomatous tumours, lymphovascular powerful factor for stage 1 disease. For pathologist, searching multiple slides can be highly time-consuming. The aim this retrospective study was develop assess an artificial intelligence...
Abstract Cancer remains one of the leading causes mortality worldwide, to increased interest in utilizing immunotherapy strategies for better cancer treatments. In past decade, CD103 + T cells have been associated with clinical prognosis patients cancer. However, specific immune mechanisms contributing toward CD103-mediated protective immunity remain unclear. Here, we show an unexpected and transient CD61 expression, which is paired at synaptic microclusters cells. colocalization cell...
Digital pathology continues to gain momentum, with the promise of artificial intelligence aid diagnosis and for assessment features which may impact prognosis clinical management. Successful adoption these technologies depends upon quality digitised whole-slide images (WSI); however, current control largely manual assessment, is inefficient subjective. We previously developed PathProfiler, an automated image tool, in this feasibility study we investigate its potential incorporation into a...
Bone marrow fibrosis is the most extensive matrix remodeling of microenvironment and can include de novo formation bone (osteosclerosis). Spatiotemporal information on contribution distinct niche populations to this process incomplete. We demonstrate that fibrosis-inducing hematopoietic cells cause profibrotic reprogramming perivascular CXCL12 abundant reticular (CAR) progenitor resulting in loss their hematopoiesis-support upregulation osteogenic pro-apoptotic programs. In turn,...
Enrichment of CD103
The use of immunohistochemistry in the reporting prostate biopsies is an important adjunct when diagnosis not definite on haematoxylin and eosin (H&E) morphology alone. process however inherently inefficient with delays while waiting for pathologist review to make request duplicated effort reviewing a case more than once. In this study, we aimed capture workflow implications requests demonstrate novel artificial intelligence tool identify cases which (IHC) required generate automated...
Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in metastasis, emergence and clones at this early stage expansion spread are poorly understood. We aimed to delineate routes within seminal vesicles lymph nodes, linking these histological features that used diagnostic risk stratification.
Abstract Background PDE6H encodes PDE6γ′, the inhibitory subunit of cGMP-specific phosphodiesterase 6 in cone photoreceptors. Inhibition PDE6, which has been widely studied for its role light transduction, increases cGMP levels. The purpose this study is to characterise cancer cell growth. Methods From an siRNA screen 487 genes involved metabolism, was identified as a controller cycle progression HCT116 cells. Role growth and metabolism through effects depletion on levels controllers, mTOR...
The past decade has seen a rapid development in content based image retrieval (CBIR). CBIR is the of images on their low level features such as color, texture, shape etc. To improve accuracy, research focus been shifted from designing sophisticated low-level feature extraction algorithms to reducing `semantic gap' between visual and richness human semantics. Image annotation techniques have proposed facilitate CBIR. This paper evaluates 7 representative machine learning for automatic...
Latent Semantic Indexing is a widely used text mining technology nowadays due its effectiveness in dealing with the problems of synonymy and polysemy within proper matrix scale. However LSI enormously computationally intensive especially for processing large scale data. And effective solution to increase computational power available using multiple computing nodes. In this paper we propose novel MapReduce based distributed Hadoop architecture implement K-means algorithm cluster documents...
Histopathology slides are routinely marked by pathologists using permanent ink markers that should not be removed as they form part of the medical record. Often tumour regions up for purpose highlighting features or other downstream processing such an gene sequencing. Once digitised there is no established method removing this information from whole slide images limiting its usability in research and study. Removal marker these high-resolution non-trivial complex problem contaminate...
The popularity of SVMs has grown tremendously in the last few years for many different classification problems due to its generalization properties, however training require high computational power. Platt's SMO is one fastest algorithm support vector machines, which takes decomposition technique extreme by selecting a set only two points as working then solving them analytically. However becomes slow large size data set. In this paper we present MapReduce based distributed implementation...