A5089376801- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Lymphoma Diagnosis and Treatment
- Autoimmune and Inflammatory Disorders Research
- Otitis Media and Relapsing Polychondritis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gut microbiota and health
- Gastrointestinal disorders and treatments
- Dermatological and COVID-19 studies
- Spondyloarthritis Studies and Treatments
- Adolescent and Pediatric Healthcare
- HIV Research and Treatment
- COVID-19 and healthcare impacts
- Immune Response and Inflammation
- Herpesvirus Infections and Treatments
- Barrier Structure and Function Studies
- Psoriasis: Treatment and Pathogenesis
- Venous Thromboembolism Diagnosis and Management
- HIV/AIDS drug development and treatment
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
Nuffield Orthopaedic Centre
2021-2025
Oxford University Hospitals NHS Trust
2021-2023
Hospital Universitario La Paz
2023
University of Oxford
2021-2023
Instituto de Investigación Marqués de Valdecilla
2023
John Radcliffe Hospital
2019
King's College London
2016
Guy's Hospital
2016
The HIV-1 envelope glycoprotein trimer is covered by an array of N-linked glycans that shield it from immune surveillance. high density on the surface imposes steric constraints limiting actions glycan-processing enzymes, so multiple under-processed structures remain specific areas. These oligomannose are recognized broadly neutralizing antibodies (bNAbs) not thwarted glycan but, paradoxically, target it. Our site-specific glycosylation analysis a soluble, recombinant (BG505 SOSIP.664) maps...
COVID-19 drastically changed healthcare delivery models for rheumatology services. We sought to understand the impact of these changes patients with Rheumatoid Arthritis (RA) and adult Juvenile Inflammatory (AJIA) in established those newly diagnosed during pandemic. RESULTS: Of 316 participants, a significant proportion regularly used analgesics (45.4%, n = 119), corticosteroids (17.9%, 47) Non-Steroidal Anti-Inflammatory Drugs [(NSAIDs) (36.6%, 96)]. Two thirds participants (66.5%, 210)...
Abstract Case report - Introduction The COVID-19 pandemic led to drastic changes for some patients on warfarin venous thromboembolic (VTE) disease and atrial fibrillation. Warfarin monitoring necessitates frequent interaction with healthcare workers, which is sufficiently risky transmission. As a result, selected were swapped over novel oral anticoagulants (NOACs). Our patient was changed without investigating antiphospholipid syndrome (APLS); it later transpired he triple antibody positive....
Abstract Background/Aims Little is known about the association between ethnicity and response to TNF inhibitors (TNFi) in people with rheumatoid arthritis (RA). This study examines self-reported DAS28 after 6 months of treatment patients starting their first TNFi using data from British Society for Rheumatology Biologics Register RA. Methods 14133 RA were included. Due a very low proportion non-white patients, was divided into white or analysis. Outcomes included change disease activity...
Abstract Background/Aims COVID-19 challenged traditional care models and necessitated introduction of remote consultations. We wanted to understand the experiences people with rheumatoid arthritis (RA)/adult juvenile idiopathic (AJIA) on accessing healthcare remotely, how well understood their condition treatment. Methods This collaborative work between National Rheumatoid Arthritis Society (NRAS) clinicians in Oxford led development an electronic questionnaire that was disseminated July...
<h3>Background</h3> Little is known about the association between ethnicity and response to TNF inhibitors (TNFi) in people with rheumatoid arthritis (RA). <h3>Objectives</h3> This study examines self-reported DAS28 after 6 months of treatment patients starting their first TNFi using data from British Society for Rheumatology Biologics Register RA. <h3>Methods</h3> 14133 RA were included. Due a very low proportion non-white patients, was divided into white or analysis. Outcomes included...
Abstract Background/Aims Giant cell arteritis (GCA) is a common form of vasculitis, but sometimes this condition can manifest as aortitis. Diagnosis aortitis trickier than the cranial presentation GCA. It often leads to prolonged treatment and cause complications such aortic dissection. Here we report our centre’s experience managing patients with Methods We retrospectively analysed that were diagnosed between 2006 2019. They identified by their diagnosis code on locally developed database....
Background: Aortitis, a rare form of large vessel vasculitis, may occur in the context primary systemic as part autoimmune disease or isolation. The evidence and guidelines to diagnose, manage monitor aortitis remain limited. However, PET CT vascular MRI scans have facilitated our ability make diagnosis more readily. optimal management strategy complication rates uncertain. Objectives: Our aim was explore clinical, laboratory radiological features aortitis. We sought review complications...