A5029193472- Mosquito-borne diseases and control
- Amoebic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Vector-borne infectious diseases
- Eosinophilic Disorders and Syndromes
- Leptospirosis research and findings
- Infectious Encephalopathies and Encephalitis
- Viral Infections and Vectors
- Rheumatoid Arthritis Research and Therapies
- Diagnosis and treatment of tuberculosis
- Neurological and metabolic disorders
- Systemic Lupus Erythematosus Research
- Food Allergy and Anaphylaxis Research
- Head and Neck Surgical Oncology
- Cardiac Arrhythmias and Treatments
- Viral Infections and Immunology Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Facial Nerve Paralysis Treatment and Research
- Parasitic infections in humans and animals
- Congenital Heart Disease Studies
- Sinusitis and nasal conditions
- Parathyroid Disorders and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects and Toxicity Studies
- Pancreatitis Pathology and Treatment
King's College London
2022-2025
Government Medical College and Hospital
2015-2025
Government Medical College and Hospital
2014-2024
Kasturba Medical College, Manipal
2024
Gartnavel General Hospital
2013-2024
Physiotherapy New Zealand
2024
Bhaikaka University
2021-2024
Pramukhswami Medical College
2013-2024
Calgary Laboratory Services
2024
Guru Gobind Singh Medical College and Hospital
2017-2023
Reduced sarcoplasmic calcium ATPase (SERCA2a) expression has been shown to play a significant role in the cardiac dysfunction diabetic cardiomyopathy. The mechanism of SERCA2a repression is, however, not known. This study was designed examine effect resveratrol (RSV), potent activator SIRT1, on function and chronic type 1 diabetes. Adult male mice were injected with streptozotocin (STZ) fed either regular diet or enriched RSV. STZ administration produced progressive decline function,...
Abstract Introduction Prior estimates of dementia prevalence in India were based on samples from selected communities, inadequately representing the national and state populations. Methods From Longitudinal Aging Study (LASI) we recruited a sample adults ages 60+ administered rich battery neuropsychological tests an informant interview 2018 through 2020. We obtained clinical consensus rating status for subsample ( N = 2528), fitted logistic model this subsample, then imputed all other LASI...
RORγt is necessary for the generation of TH17 cells but molecular mechanisms regulation are still not fully understood. We show that activation CD4+ T results in expression inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced cell differentiation without major effects on either TH1 or TH2 lineages, whereas endothelial NOS (eNOS) neuronal (nNOS) mutant showed comparable compared with wild-type control mice. The addition N6-(1-iminoethyl)-l-lysine dihydrochloride...
TH17 cells are recognized as a unique subset of T helper that have critical roles in the pathogenesis autoimmunity and tissue inflammation. Although RORγt is necessary for generation cells, molecular mechanisms underlying functional diversity not fully understood. Here we show member interferon regulatory factor (IRF) family transcription factors, IRF8, has role silencing TH17-cell differentiation. Mice with conventional knockout, well cell-specific deletion, Irf8 gene exhibited more...
<b>Aim:</b> Complementary and alternative medicine (CAM) has been practiced in India for thousands of years. The aim this study was to determine the extent use, perception attitude doctors patients utilizing same healthcare facility.<br> <b>Methods:</b> This conducted among 200 working at a tertiary care teaching Hospital, 403 attending same, usage, toward CAM.<br> <b>Results:</b> use CAM more (58%) when compared with (28%). Among doctors, those who had utilized themselves, recommended as...
Changes in oxygen radical mechanisms during 6-48 weeks of heart hypertrophy rats subjected to a narrowing the subdiaphragmatic aorta were examined. During this period, hypertrophied hearts demonstrated stable hyperfunction, as indicated by an elevated but left ventricular systolic pressure, dP/dt, and aortic pressure no change end diastolic pressure. Experimental animals showed increased heart-to-body weight ratios; however, conventional signs failure such wet-to-dry ratios liver lung,...
Autophagy, activated by many stresses, plays a critical role in innate immune responses. Here we show that interferon regulatory factor 8 (IRF8) is required for the expression of autophagy-related genes dendritic cells. Furthermore macrophages, IRF8 induced multiple autophagy-inducing including IFNγ and Toll-like receptor stimulation, bacterial infection, starvation macrophage colony-stimulating factor. directly activates involved various steps autophagy, promoting autophagosome formation...
Introduction Social media use (SMU) is highly prevalent amongst young people and previous research suggests an association with mental health problems, including poor body image. However, the potential relationship between SMU dysmorphic disorder (BDD) has received little attention. Furthermore, known about factors that moderate symptoms. The current study tested associations three facets of symptoms explored perfectionism as a moderator in non-clinical sample. Method Two-hundred nine...
Effective face-to-face treatments for Post-Traumatic Stress Disorder (PTSD) are available, but most young people with PTSD do not receive effective treatment. Therapist-supported online Cognitive Therapy has the potential to improve accessibility of This early-stage trial gathered data on feasibility, acceptability, and initial signal clinical efficacy a novel program PTSD. A two-arm, parallel-groups, single-blind, feasibility RCT compared waitlList condition. Participants were N = 31...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect any organ in body. Kidneys be involved 50% of SLE patients. Due to widespread use steroids and immunosuppressants SLE, patients are predisposed infections which major cause morbidity mortality SLE.
Abstract Background: Red cell distribution width (RDW) and platelet-to-lymphocyte ratio (PLR) may have a prognostic relationship with the severity of diabetic ketoacidosis (DKA). This study intended to explore any RDW as well PLR values DKA its various outcomes. Methods: Adult patients were recruited from medicine emergency. along measured. The illness was determined using American diabetes association (ADA) criteria for quick Sequential Organ Failure Assessment (qSOFA) at admission....
Abstract Background Disordered differentiation and hyperproliferation of keratinocytes with inflammation are the hallmarks psoriasis. Ligand activation peroxisome proliferator receptor‐γ (a class nuclear receptors) by thiazolidinediones can normalize histologic features Method In a 10‐week, double‐blind, randomized, placebo‐controlled, parallel‐group study, 70 patients moderate to severe psoriasis received one following treatments: pioglitazone 15 mg, 30 mg or placebo. Efficacy was evaluated...
Background.Pulmonary rehabilitation (PR) is an evidence-based intervention in patients with chronic obstructive pulmonary disease (COPD) which improves the exercise capacity and quality of life (QoL).Methods.We studied 60 after episode acute exacerbation COPD (AECOPD).They were randomised to receive conventional treatment without (CTWPR) (n=30) or, standard plus a 12-week post-exacerbation (PEPR) programme addition.Assessment by six minute walk test (6MWT) QoL measured St George's...
Abstract The Harmonized Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD) is a nationally representative in-depth study cognitive aging and dementia. We present publicly available dataset harmonized measures 4,096 adults 60 years age older India, collected across 18 states union territories. Blood samples were obtained to carry out whole blood serum-based assays. Results are included venous specimen datafile that can be linked LASI-DAD dataset. A global...
The effects of 3'-azido-3'-deoxythymidine (AZT) and three its intracellular metabolites, azido- thymidine mono-, di-, triphosphates, on the human immunodeficiency virus type 1 integrase have been determined. AZT triphosphate an IC50 for integration between 110 150 microM, whereas does not inhibit integrase. inhibition by monophosphate can be partially reversed coincubation with either or 2',3'-dideoxythymidine monophosphate, suggesting that these monophosphates bind to but azido group at 3'...
<i>Background:</i> Although mortality of Whipple’s pancreaticoduodenectomy (WPD) is reduced to <5%, morbidity still remains between 30 and 50%. Pancreaticojejunal anastomosis the main cause morbidity. Blumgart using transpancreatic U sutures has been proposed decrease leak rate its associated We analyzed results applied in consecutive cases WPD. <i>Methods:</i> Of 189 patients with periampullary or pancreatic cancer admitted, 100 underwent Except for 2 (no duct...
Dendritic cells (DCs) are heterogeneous cell populations represented by different subtypes, each varying in terms of gene expression patterns and specific functions. Recent studies identified transcription factors essential for the development DC yet molecular mechanisms developmental program functions remain poorly understood. In this study, we developed characterized a mouse progenitor-like line, designated DC9, from Irf8(-/-) bone marrow as model function. Expression Irf8 DC9 led to...
To evaluate the effectiveness of surgical intervention in managing empyema thoracis children.A total 70 patients aged 1-14 years diagnosed to have and who underwent tube thoracostomy from January 2010 December 2013 were studied. All which 12 needed decortication.The mean age study group was 5.44 48.6% male 51.4% female. The most common symptoms at admission fever (90%), dyspnoea (73%), cough (70%) chest pain (23%). Pleural fluid cultures sterile 60% patients. frequently identified...
Diabetes mellitus, a major lifestyle disease is undoubtedly the most challenging public health problem of 21st century with worldwide prevalence 387 million (8.3%) and predicted to be 592 by 2035. 77% people diabetes live in low- middle-income countries. India, once known as 'diabetes capital world' was home 61.3 patients T2DM 2011 predictions 101.2 diabetics 2030. India second only China which 92.3 diabetics. The International Federation estimated doubling diabetic population between 1995...