A5057382778- Intensive Care Unit Cognitive Disorders
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Anesthesia and Pain Management
- Treatment of Major Depression
- Cardiac, Anesthesia and Surgical Outcomes
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Pain Mechanisms and Treatments
- Gastric Cancer Management and Outcomes
- Cancer, Stress, Anesthesia, and Immune Response
- Nausea and vomiting management
- Immune Response and Inflammation
- Diet and metabolism studies
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Hemodynamic Monitoring and Therapy
- Traumatic Brain Injury and Neurovascular Disturbances
- Respiratory Support and Mechanisms
- Cancer-related molecular mechanisms research
- Sepsis Diagnosis and Treatment
- Gut microbiota and health
- Airway Management and Intubation Techniques
First Affiliated Hospital of Zhengzhou University
2018-2025
Jiangsu Province Hospital
2012-2025
Air Force Medical University
2014-2025
Ningxia Medical University
2006-2025
Xijing Hospital
2014-2025
Xinjiang University
2022-2025
Westlake University
2025
Xinjiang Medical University
2025
University of Virginia
2025
First Affiliated Hospital of Xinjiang Medical University
2025
Abstract Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that ketamine's probably attributed to activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. The present study aimed observe AMPA receptor modulators on mammalian target rapamycin (mTOR) brain-derived neurotrophic factor (BDNF) expression during procedure...
Abstract Here we show that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without major effects on alternatively M2 macrophages. eNOS and nNOS mutant comparable compared with wild-type control mice. Addition of N6-(1-iminoethyl)-L-lysine dihydrochloride, an iNOS inhibitor, significantly enhances while S-nitroso-N-acetylpenicillamine, a NO donor, suppresses polarization. derived from mediates nitration tyrosine residues in IRF5 protein, leading to the...
Sepsis-associated encephalopathy (SAE) is a common complication that leads to long-term cognitive impairments and increased mortality in sepsis survivors. The mechanisms underlying this remain unclear an effective intervention lacking. Accumulating evidence suggests the nucleotide-binding domain-like receptor protein3 (NLRP3)/caspase-1 pathway involved several neurodegenerative diseases. Thus, we hypothesized NLRP3/caspase-1 NLRP3-mediated pyroptosis, maturation release of inflammatory...
Postoperative cognitive decline (POCD) is a recognized clinical phenomenon characterized by impairments in patients following anesthesia and surgery, yet its underlying mechanism remains unclear. Brain-derived neurotrophic factor (BDNF) plays an important role neuronal plasticity, learning, memory via activation of TrkB-full length (TrkB-FL) receptors. It has been reported that abnormal truncation TrkB mediated calpain results dysregulation BDNF/TrkB signaling associated with several...
Background: Remimazolam is a new medication with sedative and hypnotic effects.It has been demonstrated non-inferior to propofol in general anesthesia regard efficacy safety.However, whether remimazolam better than terms of patients' recovery quality remains unknown.Patients Methods: Patients enrolled this study were randomized or group.In group, was induced sufentanil maintained remifentanil.In remifentanil.Neuromuscular blocking agent cisatracurium also injected during anesthesia.Sedation...
Microglial activation-mediated neuroinflammation is one of the essential pathogenic mechanisms sepsis-associated encephalopathy (SAE). Mounting evidence suggests that high mobility group box-1 protein (HMGB1) plays a pivotal role in and SAE, yet mechanism by which HMGB1 induces cognitive impairment SAE remains unclear. Therefore, this study aimed to investigate underlying SAE.An model was established cecal ligation puncture (CLP); animals sham underwent cecum exposure alone without...
Background: Postoperative delirium is common in older adult patients and associated with a poor prognosis. The use of benzodiazepine was identified as an independent risk factor for delirium, but there no randomized controlled trial regarding the relationship between remimazolam, new ultra-short acting benzodiazepine, postoperative delirium. We designed to evaluate if remimazolam increases incidence compared propofol undergoing orthopedic surgery general anesthesia. Patients Methods:...
Chloroplast gene expression is primarily regulated at the post-transcriptional level, where a variety of complex mechanism have evolved to govern interaction between chloroplast and nuclear genomes. These rely on different nuclear-encoded proteins that act mRNAs, including RNA polymerase subunits, stability factors translational activators. Such control mechanisms must be viewed in light evolutionary heritage chloroplast, as an independent unicellular organism. Although some features...
IL-17 and IL-22 are typical cytokines produced by the Th17 T cell subset, but it is unclear if can be other types. We demonstrate that IL-10-deficient IL-10R-deficient macrophages stimulated with lipopolysaccharide produce high levels of IL-22. Addition exogenous IL-10 to abolished production. When splenocytes were cultured under polarizing conditions, population IL-17-producing cells was increased cultures significantly higher The addition recombinant decreased percentage CD4(+) cells....
Introduction. Previous studies have shown that a single sub-anesthetic dose of ketamine exerts fast-acting antidepressant effects in patients and animal models depression. However, the underlying mechanisms are not totally understood. This study aims to investigate acute administration different doses on immobility time rats forced swimming test (FST) determine levels hippocampal brain-derived neurotrophic factor (BDNF) mammalian target rapamycin (mTOR). Methods. Forty male Wistar weighing...
RORγt is necessary for the generation of TH17 cells but molecular mechanisms regulation are still not fully understood. We show that activation CD4+ T results in expression inducible nitric oxide synthase (iNOS). iNOS-deficient mice displayed enhanced cell differentiation without major effects on either TH1 or TH2 lineages, whereas endothelial NOS (eNOS) neuronal (nNOS) mutant showed comparable compared with wild-type control mice. The addition N6-(1-iminoethyl)-l-lysine dihydrochloride...
Pain and depression are frequently co-existent in clinical practice, yet the underlying mechanisms remain largely to be determined. Microglia activation subsequent pro-inflammatory responses play a crucial role development of neuropathic pain depression. The process microglia polarization M1 or anti-inflammatory M2 phenotypes often occurs during neuroinflammation. However, it remains unclear whether M1/M2 is involved induced by spared nerve injury (SNI). In present study, mechanical...
Abstract Background Increasing evidence suggests that multiple or long-time exposure to general anaesthesia (GA) could be detrimental cognitive development in young subjects and might also contribute accelerated neurodegeneration the elderly. Iron is essential for normal neuronal function, excess iron brain implicated several neurodegenerative diseases. However, role of GA-induced neurotoxicity deficits remains elusive. Methods We used primary hippocampal neurons rodents including rats aged...
Significance The bromodomain and extraterminal domain (BET) proteins regulate transcription of subset-specifying genes during lineage-specific T-helper-cell differentiation in adaptor immunity are also implicated inflammatory disorders. available pan-BET inhibitors such as JQ1 indiscriminately block the tandem bromodomains (BD1 BD2) BET proteins, broadly render different Th subsets, have limited therapeutic potential. Here we report a small molecule, MS402, that can selectively inhibit BD1...
Regeneration of alveolar bone is among the main purposes periodontal treatment. However, it a challenge for both dentists and patients. An injectable chitosan-based thermosensitive hydrogel scaffold (CS/CSn-GP) was successfully designed prepared with incorporation morphogenetic protein-2 plasmid DNA (pDNA-BMP2)-loaded chitosan nanoparticles (CS/CSn(pDNA-BMP2)-GP) in this study. The aim study to evaluate regenerative effect on endogenous repair bone. Thermosensitive properties, SEM scans vivo...
Ginsenoside Rh2 (GRh2) is the main bioactive component in American ginseng, a commonly used herb, and its antitumor activity had been studied previous studies. PDZ-binding kinase/T-LAK cell-originated protein kinase (PBK/TOPK), serine/threonine kinase, highly expressed HCT116 colorectal cancer cells.We examined effect of GRh2 on cells ex vivo. Next, we performed vitro binding assay to search for target GRh2. Furthermore, elucidated underlying molecular mechanisms vivo vivo.The results our...
Abstract The aim of this study is to explore the feasibility using machine learning (ML) technology predict postoperative recurrence risk among stage IV colorectal cancer patients. Four basic ML algorithms were used for prediction—logistic regression, decision tree, GradientBoosting and lightGBM. research samples randomly divided into a training group testing at ratio 8:2. 999 patients with 4 included in study. In group, model’s AUC value was highest, 0.881. Logistic lowest, 0.734. model had...