A5020515271- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Oral microbiology and periodontitis research
- Extracellular vesicles in disease
- dental development and anomalies
- Dermatologic Treatments and Research
- Tendon Structure and Treatment
- Proteoglycans and glycosaminoglycans research
- Wound Healing and Treatments
- Bone Metabolism and Diseases
- Dental Implant Techniques and Outcomes
- Obsessive-Compulsive Spectrum Disorders
- Cellular Mechanics and Interactions
- Tissue Engineering and Regenerative Medicine
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Autism Spectrum Disorder Research
- Connective tissue disorders research
- Neurotransmitter Receptor Influence on Behavior
- Bone and Dental Protein Studies
- Advanced Drug Delivery Systems
- Skin and Cellular Biology Research
- Antimicrobial Peptides and Activities
- Corneal Surgery and Treatments
- Salivary Gland Disorders and Functions
Affiliated Hospital of Qingdao University
2016-2025
Qingdao University
2016-2025
Sichuan University
2024
Southern University of Science and Technology
2024
Stanford University
2019-2023
Shandong University
2014
Regeneration of alveolar bone is among the main purposes periodontal treatment. However, it a challenge for both dentists and patients. An injectable chitosan-based thermosensitive hydrogel scaffold (CS/CSn-GP) was successfully designed prepared with incorporation morphogenetic protein-2 plasmid DNA (pDNA-BMP2)-loaded chitosan nanoparticles (CS/CSn(pDNA-BMP2)-GP) in this study. The aim study to evaluate regenerative effect on endogenous repair bone. Thermosensitive properties, SEM scans vivo...
Abstract The differentiation, migration, and proliferation of skin fibroblasts are identified as key factors in cutaneous wound healing. Adipose-derived mesenchymal stem cells (ADMSCs) their exosomes (ADMSC-Exos) have been considered potential therapeutic tools for tissue regeneration; however, the underlying mechanisms on healing still not well understood. In this study, we successfully obtained ADMSC-Exos found significantly promoted migration a dose-dependent manner vitro. expression...
To examine the immunomodulatory effect of exosomes originating from gingival mesenchymal stem cells (GMSC-Exo) on periodontal bone regeneration and its role in regulation nuclear-factor kappaB (NF-κB) Wnt/β-catenin pathways inflammatory microenvironment.First, ligament (PDLSCs) were treated with GMSC-Exo or Porphyromonas gingivalis-derived lipopolysaccharide (P.g-LPS) vitro. Quantitative real-time PCR (qRT-PCR) western blot carried out to detect expressions osteogenic differentiation-related...
Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment.Irisin, newly discovered myokine adipokine, has been found to have beneficial effects on various cardiovascular diseases.However, the pharmacological effect of irisin antagonizing hypertension-induced vascular not well understood.In present study, we investigated protection mechanisms against induced by angiotensin II (Ang II).Adult male mice wild-type, FNDC5...
This study aimed to explore the effects of exosomes derived from human gingival mesenchymal stem cells (GMSC-Exo) on inflammatory response periodontal ligament (PDLSCs) in an microenvironment order restore regenerative potential PDLSCs, which promotes tissue regeneration patients with periodontitis. Periodontitis is a chronic infectious disease characterized by inflammation and alveolar bone destruction. PDLSCs are regarded as promising seed for restoring defects because their ability...
Gingiva-derived mesenchymal stromal cells (GMSCs) have been considered as a promising alternative strategy for periodontal regeneration based on their potential multilineage differentiation in vitro and the ability to form new bone vivo. In order investigate capacity of GMSCs fate during tissue repair, enhanced green fluorescent protein-labeled were transplanted into class III furcation defects created beagle dogs. The results showed that significantly damaged tissue, including alveolar...
Objective: To explore the effectiveness of robotic implant technology in postgraduate education dentistry. Methods: The teaching method that combines theory and model manipulation was used to teach 20 students. After completing theoretical course dentistry, all students performed free hand, digital template, dental robot surgery on simulation jaw models. At end course, an error analysis three a feedback questionnaire distributed were conducted order assess robot. Results: Compared freehand...
Despite an extensive literature documenting the adaptive changes of bones and ligaments to mechanical forces, our understanding how tissues actually mount a coordinated response physical loading is astonishingly inadequate. Here, using finite element (FE) modeling in vivo murine model, we demonstrate stress distributions within periodontal ligament (PDL) caused by occlusal hyperloading. In direct response, spatially restricted pattern apoptosis triggered stressed PDL, temporal peak which...
Abstract Pathological scars (PS) are involved in the excessive response of inflammation and overactivation myofibroblasts. Herein, a novel microneedle (MN) patch based on adipose‐derived stem cell concentrated conditioned medium (ADSCC‐CM) cross‐linked keratin hydrogel is developed to load triamcinolone acetonide (TA), thereby achieving dual‐drug delivery ADSCC‐CM TA simultaneously reduce guide myofibroblast behaviors. Results not only confirm ability drive formation keratin‐based hydrogel,...
Cell-based tissue engineering is a promising alternative for periodontal regeneration as current therapies fail to reconstitute damage caused by periodontitis. As newly identified postnatal stem cells, gingiva-derived mesenchymal cells (GMSCs) have been focused on isolation and expansion in vitro of with multi-differentiation potential immunomodulatory capacities. It has demonstrated that systemically delivered GMSCs can home the mandibular bone defect sites promote regeneration. However,...
The capacity of a tissue to continuously alter its phenotype lies at the heart how an animal is able quickly adapt changes in environmental stimuli. Within tissues, differentiated cells are rigid and play limited role adapting new environments; however, replenished by stem that defined their phenotypic plasticity. Here we demonstrate Wnt-responsive cell niche junctional epithelium responsible for capability this physical consistency diet. Mechanical input from chewing required both establish...
Epithelia of the oral cavity exhibit variations in morphologies and turnover rates. Are these differences related to environment or region-specific stem cell populations? A lineage-tracing strategy allowed visualization Wnt-responsive cells, their progeny, hard soft palates. In both anatomic locations, basal cells self-renewed gave rise supra-basal cells. Palatal injuries triggered an enlargement this population, descendants were responsible for wound re-epithelialization. Compared with...
The most fundamental function of an epithelial tissue is to act as a barrier, regulating interactions between the external environment and body. This barrier typically requires contiguous cell layer but since teeth penetrate oral epithelium, modified has evolved, called junctional epithelium (JE). In health, JE attaches tooth, sealing inside body against micro-organisms. Breakdown results in periodontal ligament (PDL) disintegration, alveolar bone resorption, ultimately tooth loss. Using...
Introduction: Few interspecies comparisons of alveolar bone have been documented, and this knowledge gap raises questions about which animal models most accurately represent human dental conditions or responses to surgical interventions. Objectives: The objective study was employ state-of-the-art quantitative metrics directly assess compare the structural functional characteristics among humans, mini pigs, rats, mice. Methods: same anatomic location (i.e., posterior maxillae) analyzed in all...