A5073478609- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- PI3K/AKT/mTOR signaling in cancer
- Gastric Cancer Management and Outcomes
- Cancer Research and Treatments
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Biofield Effects and Biophysics
- Medicinal Plants and Bioactive Compounds
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Genetics and Neurodevelopmental Disorders
- Glycosylation and Glycoproteins Research
- Cancer Mechanisms and Therapy
- Helicobacter pylori-related gastroenterology studies
- Medical Research and Treatments
Fudan University
2024-2025
North Sichuan Medical University
2025
Affiliated Hospital of North Sichuan Medical College
2025
Second Affiliated Hospital of Jilin University
2025
Shaoxing People's Hospital
2023-2025
Heilongjiang University of Chinese Medicine
2025
Central South University
2013-2024
Third Xiangya Hospital
2023-2024
Capital Medical University
2014-2024
Sichuan University
2024
Abstract China is one of the countries with highest incidence gastric cancer. There are differences in epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selection between cancer patients from Eastern Western countries. Non‐Chinese guidelines cannot specifically reflect diagnosis characteristics for Chinese patients. The Society Clinical Oncology (CSCO) arranged a panel senior experts specializing all sub‐specialties to compile,...
There exist differences in the epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selections between gastric cancer patients from Eastern Western countries. The Chinese Society of Clinical Oncology (CSCO) has organized a panel senior experts specializing all sub-specialties to compile clinical guideline for diagnosis since 2016 renews it annually. Taking into account regional differences, giving full consideration accessibility...
MPDL3280A is a human monoclonal antibody that targets programmed cell death-1 ligand 1 (PD-L1), and exerts anti-tumor activity mainly by blocking PD-L1 interaction with (PD-1) B7.1. It being investigated as potential therapy for locally advanced or metastatic malignancies. The purpose of the study reported here was to characterize pharmacokinetics, pharmacodynamics, tissue distribution tumor penetration and/or chimeric anti-PD-L1 PRO304397 help further clinical development. pharmacokinetics...
Abstract The 2023 update of the Chinese Society Clinical Oncology (CSCO) Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China, reflecting latest advancements evidence‐based medicine, healthcare resource availability, precision medicine. These updates address differences epidemiological characteristics, clinicopathological features, tumor biology, patterns, drug selections between Eastern Western gastric patients. Key revisions include a structured...
Patients with hematogenous metastatic lung cancer displayed significantly increased platelet count and aggregation compared to patients without metastasis. The mechanism underlying the correlation between metastasis activation remains unknown. In present study, we explored role of microRNA-223 (miR-223) derived from platelets in modulating cell invasion. Our results demonstrated that NSCLC contain higher level miR-223 than healthy subjects. concentration platelet-secreted microvesicles...
Vascular remodeling plays a vital role in hypertensive diseases and is an important target for hypertension treatment.Irisin, newly discovered myokine adipokine, has been found to have beneficial effects on various cardiovascular diseases.However, the pharmacological effect of irisin antagonizing hypertension-induced vascular not well understood.In present study, we investigated protection mechanisms against induced by angiotensin II (Ang II).Adult male mice wild-type, FNDC5...
// Dan Sun 1 , Xiaoting Li 2 Yingjian He Wenhui Ying Wang Huan Shanshan Jiang Yan Xin Laboratory of Gastrointestinal Onco-Pathology, Cancer Institute and General Surgery Institute, The First Affiliated Hospital China Medical University, Shenyang 110001, Liaoning Province, Key laboratory Carcinogenesis Translational Research (Ministry Education), Peking University Beijing, 100142, Correspondence to: Xin, email: yxin@mail.cmu.edu.cn Keywords: yes-associated protein1/YAP1, gastric cancer,...
Abstract Background Circular RNAs (circRNAs) have been reported to be important regulators of the development and progression various carcinomas. However, role circRNA_100290 in gastric cancer (GC) is still unclear. This study aimed investigate GC invasion metastasis possible underlying mechanism. Methods The expression cells tissues was examined using quantitative real-time polymerase chain reaction (qRT-PCR). cell proliferation, migration, evaluated AGS HGC-27 lines vitro. Bioinformatics...
Objective To explore their association with the development of diabetes retinopathy (DR), single nucleotide polymorphism (SNP) mutations were screened out by high-throughput sequencing and validated in patients diagnosed DR. understand role PIK3CA pathogenesis DR relationship between PIK3CA,phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target rapamycin (mTOR),and DR, effect PIK3CA.rs17849079 mutation was investigated a cell model. Methods Twelve at Qinghai Provincial...
No AccessJournal of UrologyInvestigative Urology1 Apr 2011Paclitaxel Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy Ze Lu, Teng-Kuang Yeh, Jie Wang, Ling Chen, Greg Lyness, Yan Xin, M. Guillaume Wientjes, Valerie Bergdall, Guillermo Couto, Francisco Alvarez-Berger, Carrie E. Kosarek, and Jessie L.-S. Au LuZe Lu Optimum Therapeutics, L. C., Ohio State University, Columbus, , YehTeng-Kuang Yeh WangJie Wang ChenLing Chen LynessGreg Lyness XinYan Xin WientjesM. Wientjes Colleges...
Matrix metalloproteinase-9 is a proteolytic enzyme whose expression increased in ulcerative colitis.To evaluate the safety and efficacy of GS-5745, fully humanised anti-matrix monoclonal antibody, moderately-to-severely active colitis.We randomised 74 patients with colitis to treatment single or multiple ascending intravenous subcutaneous doses GS-5745 placebo. Multiple-dose cohorts received either IV infusions (0.3, 1.0, 2.5 5.0 mg/kg placebo) every 2 weeks (three total infusions) five...
Low temperature is an environmental stress factor that always been applied in research on improving crop growth, productivity, and quality of crops. Polyunsaturated fatty acids (PUFAs) play important role cold tolerance, so its genetic manipulation the PUFA contents crops has led to modification sensitivity. In this study, we over-expressed ω-3 acid desaturase from Glycine max (GmFAD3A) drove by a maize ubiquitin promoter rice. Compared wild type (ZH11), ectopic expression GmFAD3A increased...
BACKGROUND Cut throat injury (CTI) is a type of penetrating neck that an emergency in otorhinolaryngology and head surgery. CASE REPORT We report 2 cases CTI zone 2. Patient 1 had severe to the larynx, trachea, esophagus due attempted suicide, whereas ruptured larynx homicide, without vocal cords. The doctor only used gauze compress rather than inserting tracheal cannula through opening immediately maintain airway patency. dyspnea at point. Fortunately, stable wound did not bleed much, with...
Abstract Hepatocellular carcinoma (HCC) is among the most malignant tumors and seriously threatens human health worldwide, its incidence rate increasing annually. USP15 a member of ubiquitination-specific protease (USP) family, which can regulate protein ubiquitination, thereby affecting their stability, dysregulated in many cancers, but expression regulatory mechanism HCC are unclear. The aims this study were to explore role regulating cell stemness, proliferation, lenvatinib resistance....
Objectives: Iron-deficiency anemia is one of the most common nutritional deficiencies worldwide. Polysaccharide–iron complexes (PICs), as novel organic iron supplements, have garnered increasing attention due to their high bioavailability, minimal gastrointestinal irritation, and favorable tolerability. However, different formulations PICs can show significant variations in physicochemical properties bioavailability. These factors are crucial for clinical efficacy safety. Methods: This study...
Context: Globally, the prevalence of non-alcoholic steatohepatitis (NASH) is increasing, leading to a substantial economic burden and becoming one most common reasons for liver transplantation. The lack effective therapeutic interventions reduce disease progression makes NASH major global healthcare problem in both developing developed countries. This evidence-based review reports studies that evaluated effectiveness different sodium-glucose transport protein-2 (SGLT-2) inhibitors treating...
Utilizing whole-brain functional magnetic resonance imaging(fMRI) to investigate abnormal spontaneous brain activity in the resting state of patients with trigeminal neuralgia (TN) and explore their relationship pain symptoms negative emotions. This study included 46 TN diagnosed at our hospital from December 2022 June 2023 35 healthy controls (HCs). All completed questionnaires related The data analysis used DPABI toolkit based on MATLAB platform compared amplitude low frequency fluctuation...
Nerve injury represents the primary reason of mortality and disability in ischemic stroke, but effective drug delivery to region cerebral ischemia hypoxia poses a significant challenge neuroprotective treatment. To address these clinical challenges, biomimetic nanomotor, Pt@LF is designed, facilitate deep agents inhibit ferroptosis stroke. traverses blood-brain barrier (BBB) penetrates into ischemic-hypoxic areas due active targeting capacity apo-lactoferrin (Apo-LF) self-propelling motion...