A5006455181- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Gastrointestinal Tumor Research and Treatment
- Cell death mechanisms and regulation
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Cancer Treatment and Pharmacology
- Metastasis and carcinoma case studies
- Autophagy in Disease and Therapy
First Hospital of China Medical University
2016-2025
China Medical University
2016-2025
Ministry of Education of the People's Republic of China
2020-2025
Shenyang Center for Disease Control and Prevention
2022
Sun Yat-sen University
2006-2020
Fifth Affiliated Hospital of Sun Yat-sen University
2006-2020
Shenyang Pharmaceutical University
2019
General Hospital of Shenyang Military Region
2017
Jingdong (China)
2017
GTx (United States)
2015
There exist differences in the epidemiological characteristics, clinicopathological features, tumor biological treatment patterns, and drug selections between gastric cancer patients from Eastern Western countries. The Chinese Society of Clinical Oncology (CSCO) has organized a panel senior experts specializing all sub-specialties to compile clinical guideline for diagnosis since 2016 renews it annually. Taking into account regional differences, giving full consideration accessibility...
Abstract The 2023 update of the Chinese Society Clinical Oncology (CSCO) Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China, reflecting latest advancements evidence‐based medicine, healthcare resource availability, precision medicine. These updates address differences epidemiological characteristics, clinicopathological features, tumor biology, patterns, drug selections between Eastern Western gastric patients. Key revisions include a structured...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal solid tumors. The tumor immune microenvironment (TIME) formed by interactions among cancer cells, cancer-associated fibroblasts (CAF), and extracellular matrix (ECM) components drives PDAC in a more immunosuppressive direction: this major cause therapy resistance poor prognosis. In recent years, research has advanced our understanding signaling mechanism which TIME interact with evolution immunophenotyping. Through...
Kirsten rats sarcoma viral oncogene (KRAS), the first discovered human oncogene, has long been recognized as "undruggable". KRAS mutations frequently occur in multiple cancers including non-small cell lung cancer(NSCLC), colorectal cancer(CRC) and pancreatic ductal adenocarcinoma(PDAC), functioning a "molecule switch" determining activation of various oncogenic signaling pathways. Except for its intrinsic pro-tumorigenic role, alteration also exhibits an unique immune signature characterized...
Bufalin is the active ingredient of Chinese medicine Chan Su, and it has been reported that bufalin induces apoptosis in some human leukemia solid cancer cell lines. The exact mechanism bufalin-induced is, however, still not clear. In this study, we demonstrated inhibited proliferation gastric MGC803 cells a dose-dependent time-dependent manner. At low concentration (20 nmol/l), induced M-phase cycle arrest, whereas at high (80 nmol/l) cells. increased Bax/Bcl-2 ratio activated caspase-3...
β-Elemene, a compound found in an herb used traditional Chinese medicine, has shown promising anti-cancer effects against broad spectrum of tumors. The mechanism by which β-elemene kills cells remains unclear. aim the present study is to investigate anti-tumor effect on human gastric cancer and molecular involved. β-Elemene inhibited viability MGC803 SGC7901 dose-dependent manner. suppression cell was due induction apoptosis. A robust autophagy observed treated with β-elemene; it...
The abnormal m6A modification caused by modulators is a common feature of various tumors; however, little known about which modulator plays the most important role in triple-negative breast cancer (TNBC). In this study, when analyzing influence (METTL3, METTL14, WTAP, FTO, and ALKBH5) on prognosis cancer, especially TNBC using several on-line databases, methyltransferase-like 3 (METTL3) was found to have low expression closely associated with short-distance-metastasis-free survival TNBC....
Background: Lung cancer is the leading cause of cancer-related death worldwide. Although macrophages can affect development tumor, contribution to prognosis non-small-cell lung (NSCLC) still controversial. Moreover, anti-PD-1 therapy redirect from an M2 M1 phenotype, suggesting that tumor PD-L1 may prognostic role macrophages. Therefore, in this study, we aimed display a macrophage landscape clarify function macrophages, considering localization and polarization evaluate effect combination...
Summary Human peripheral blood monocytes are a heterogeneous population, including CD14+CD16- ‘classical’ and CD14+CD16+‘proinflammatory’ monocytes. CD16+ expanded in various inflammatory conditions. However, little is known about the CD14+CD16+ patients with breast cancer. We detected 96 cancer 54 control subjects using flow cytometry. Receiver-operating characteristic (ROC) curve analysis was used to determine feasibility of as an indicator for diagnosis found that frequency showed...
Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many tumors; however, the molecular mechanism by which this occurs is not clearly understood. Additionally, little known about involvement of IGF-I gastric cancer. Two cancer cell lines were treated with to EMT and levels transcription ZEB2 microRNA-200c (miR-200c) measured. Cells Akt/ERK inhibitors investigate role these pathways IGF-I-mediated EMT. Transfection shRNA plasmids was used silence...
Anti-PD-1/PD-L1 therapies have demonstrated prominent clinical effects in the treatment of non-small cell lung cancer (NSCLC). However, limited understanding regulatory mechanisms PD-L1 has become one biggest challenges for further improving efficacy. In this study, we observed that wild-type EFGR lines A549 and H460, ubiquitin ligases Cbl-b c-Cbl inhibit by inactivating STAT, AKT, ERK signaling. MiR-181a miR-940 were screened validated to target c-Cbl, respectively. Furthermore, NSCLC...
Anti-PD-1 therapy has been approved for cancer treatment. However, the response rate is unsatisfactory. The expression of PD-L1 in tumor tissues unreliable to predict treatment response. Recent studies have suggested that exosomal not only exerts immunosuppressive effects but also plays a significant role development microenvironment. Thus, present study aims investigate improving its predictive value and efficacy. A total 44 patients advanced tumors several types, treated with anti-PD-1...
Abnormal RNA m6A methylation is known to lead the occurrence and progression of multiple cancers including gastric cancer (GC). However, integrative effects all regulators on GC prognosis are unclear. Our research aimed globally analyze values 33 in by univariate multivariate Cox regression analyses. Among regulators, fat mass obesity-associated protein (FTO), an demethylase, was identified as a key prognostic risk factor overall survival (OS) patients. It found that FTO could promote cell...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor factor family that selectively induces apoptosis in cancer cells. However, gastric cells are insensitive to TRAIL. In present study, we show oxaliplatin enhanced TRAIL-induced MGC803, BGC823, and SGC7901 Oxaliplatin promoted death receptor 4 (DR4) 5 (DR5) clustering into aggregated lipid rafts, while cholesterol-sequestering agent nystatin partially prevented raft aggregation, DR4 DR5 clustering, reduced...
Background: Renal-cell carcinoma (RCC) is resistant to almost all chemotherapeutics and radiation therapy. <TEX>${\beta}$</TEX>-Elemene, a promising anticancer drug extracted from traditional Chinese medicine, has been shown be effective against various tumors. In the present study, anti-tumor effects on RCC cells involved mechanisms were investigated. Methods: Human 786-0 treated with different concentrations of <TEX>${\beta}$</TEX>-elemene, cell viability apoptosis measured by 3-(4,...
MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR its parent SGC7901 using microarray. MiR-103/107 was downregulated compared parental cells. Overexpression miR-103/107 sensitized cells doxorubicin (DOX), as demonstrated by in vitro vivo drug...