A5088911520- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Reproductive Biology and Fertility
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Acupuncture Treatment Research Studies
- Birth, Development, and Health
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Peptidase Inhibition and Analysis
- Prenatal Screening and Diagnostics
- Wnt/β-catenin signaling in development and cancer
- Lung Cancer Research Studies
- Traditional Chinese Medicine Studies
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- RNA Research and Splicing
Qilu Hospital of Shandong University
2016-2025
Central South University
2008-2025
Peking Union Medical College Hospital
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Beijing Institute of Big Data Research
2025
Central South University of Forestry and Technology
2025
Shaanxi Normal University
2022-2025
Wuhan University
2011-2024
Renmin Hospital of Wuhan University
2018-2024
Nanjing Tech University
2024
In the mammalian ovary, progressive activation of primordial follicles from dormant pool serves as source fertilizable ova. Menopause, or end female reproductive life, occurs when follicle is exhausted. However, molecular mechanisms underlying are poorly understood. We provide genetic evidence that in mice lacking PTEN (phosphatase and tensin homolog deleted on chromosome 10) oocytes, a major negative regulator phosphatidylinositol 3-kinase (PI3K), entire becomes activated. Subsequently, all...
BACKGROUND: Long non-coding RNA (lncRNA) H19 has been well studied playing an important role in breast cancer (BC) progress and the expression of may service as a diagnostic target for BC. However, it is unclear if circulating lncRNA could potential biomarker BC diagnosis monit or. OBJECTIVE: The objective our study was to determine whether plasma be used biomarkers screening early cancer. METHODS: In this study, we carried out quantitative real-time PCR (qRT-PCR) method examine levels 24...
MicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS) and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role IS therapy. Herein we hypothesized that BMSCs-derived containing overexpressed miR-138-5p could protect astrocytes following involved with lipocalin 2 (LCN2).The differentially expressed gene related to was initially identified by bioinformatics analysis. predicted regulate LCN2. The expression LCN2 altered oxygen-glucose deprivation...
Abstract Despite neoadjuvant/conversion chemotherapy, the prognosis of cT4a/bN+ gastric cancer is poor. Immune checkpoint inhibitors (ICIs) and antiangiogenic agents have shown activity in late-stage cancer, but their efficacy setting unclear. In this single-armed, phase II, exploratory trial (NCT03878472), we evaluate a combination ICI (camrelizumab), antiangiogenesis (apatinib), chemotherapy (S-1 ± oxaliplatin) for treatment cancer. The primary endpoints are pathological responses...
In recent years, mammalian oocytes have been proposed to important roles in the orchestration of ovarian follicular development and fertility. To determine whether intra-oocyte Foxo3a, a component phosphatidylinositol 3-kinase (PI3K) signaling pathway, influences female fertility, transgenic mouse model was generated with constitutively active Foxo3a expressed oocytes. We found that mice were infertile, which caused by retarded oocyte growth development, anovulation. Further mechanistic...
Immature ovarian primordial follicles are essential for maintenance of the reproductive lifespan female mammals. Recently, it was found that overactivation phosphatidylinositol 3-kinase (PI3K) signaling in oocytes by an oocyte-specific deletion Pten (phosphatase and tensin homolog deleted on chromosome ten), gene encoding PI3K negative regulator PTEN, results premature activation entire pool follicles, indicating pathway is important control follicular activation. To investigate whether...
R1507 is a selective, fully human, recombinant monoclonal antibody (immunoglobulin G1 subclass) against insulin-like growth factor-1 receptor (IGF-1R). The strong preclinical evidence supporting coinhibition of IGF-1R and epidermal factor (EGFR) as anticancer therapy prompted this study.
Abstract Oleuropein is one of the most abundant phenolic compounds found in olives. Epidemiological studies have indicated that an increasing intake olive oil can significantly reduce risk breast cancer. However, potential effect(s) oleuropein on estrogen receptor (ER)‐negative cancer not fully understood. This study aims to understand anticancer effects and underlying mechanism(s) ER‐negative cells vitro. The effect viability cell lines was examined by mitochondrial dye‐uptake assay,...
Abstract N 6 -methyladenosine (m A) is the most common epigenetic RNA modification with essential roles in cancer progression. However, of m A and its regulator METTL3 on non-coding gastric are unknown. In this study, we found elevated levels cancer. Increased expression indicated poor outcomes patients high malignancy vitro vivo. Mechanically, facilitated processing pri-miR-17-92 into miR-17-92 cluster through an A/DGCR8-dependent mechanism. The that mediated process occurred A879 locus...
Background The tumor microenvironment (TME) plays a pivotal role in cancer progression papillary thyroid carcinoma (PTC), yet the composition and phenotype of cells within TME bilateral PTC are poorly understood. Methods We performed unbiased transcriptome-wide single-cell RNA sequencing (scRNA-seq) analysis on 29,561 from 3 pairs 1 non-tumor sample. results were validated by large-scale bulk transcriptomic dataset deposited Cancer Genome Atlas (TCGA) database. Results Our integrative...
Urban street spaces play a crucial role in children’s daily commuting and social activities. Therefore, the design of these must give more consideration to perceptual preferences. Traditional landscape perception studies often rely on subjective analysis, which lacks objective, data-driven insights. This study overcomes this limitation by using eye-tracking technology evaluate preferences scientifically. We collected data from 57 children aged 6–12 as they naturally viewed 30 images...
In humans, the molecular mechanisms underlying ovarian follicle endowment and activation, which are closely related to control of female reproduction, occurrence menopause, diseases such as premature failure, poorly understood. current study, we provide several lines genetic evidence that cyclin-dependent kinase (Cdk) inhibitor 1B (commonly known p27(kip1) or p27) controls development in mice by suppressing promoting death. p27-deficient (p27(-/-)) mice, postnatal assembly was accelerated,...
E-cadherin is a well characterized adhesion molecule that plays major role in epithelial cell adhesion. Based on findings expression of frequently lost human cancers, it has been implicated as tumor suppressor carcinogenesis most cancers. However, ovarian cancer development, our data from the current study showed uniquely elevated 86.5% benign, borderline, and malignant carcinomas irrespective degree differentiation, whereas normal samples do not express E-cadherin. Thus, we hypothesize may...
Trophectoderm (TE) biopsy and DNA microarray have become the new technologies for preimplantation genetic diagnosis in humans. In this study, we comprehensively examined aneuploid formation human blastocysts produced vitro with investigated clinical outcome after transfer of euploid embryos. Biopsied cells from either TE or inner cell mass (ICM) were processed to examine errors 23 pairs chromosomes consistency between ICM. It was found that 56.6% aneuploid. Further analysis indicated 62.3%...
Significance Whether or not oocyte regeneration occurs in the adult mammalian ovary has been subject of much debate. By performing a series vivo cell-lineage tracing experiments, we have supplied compelling evidence that oocytes are regenerated from any putative germline stem cells life. Our current study provides conclusive initial pool is only source fertility throughout reproductive life mammals.
Long noncoding RNAs (lncRNAs) have been identified to play increasingly important roles in tumorigenesis, and they may serve as novel biomarkers for cancer therapy. LncRNA NBR2 (neighbor of BRCA1 gene 2), a lncRNA, is demonstrated decrease several cancers. However, it still unknown whether lncRNA involved hepatocellular carcinoma autophagy. We found that HCC cases with lower expression had significantly worse overall survival than those higher advanced patients. And the was negatively...