A5100756203- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Rheumatoid Arthritis Research and Therapies
- Genetic factors in colorectal cancer
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Systemic Lupus Erythematosus Research
- Neuroendocrine Tumor Research Advances
- Osteoarthritis Treatment and Mechanisms
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Autoimmune and Inflammatory Disorders Research
- Cancer, Stress, Anesthesia, and Immune Response
Zhongshan Hospital
2023-2024
Fudan University
2023-2024
Sun Yat-sen University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Wuxi No.2 People's Hospital
2022-2023
Soochow University
2020-2023
First Affiliated Hospital of Soochow University
2020-2023
Yebio Bioengineering (China)
2018-2023
Affiliated Hospital of Nantong University
2023
Nantong University
2023
Abstract Despite neoadjuvant/conversion chemotherapy, the prognosis of cT4a/bN+ gastric cancer is poor. Immune checkpoint inhibitors (ICIs) and antiangiogenic agents have shown activity in late-stage cancer, but their efficacy setting unclear. In this single-armed, phase II, exploratory trial (NCT03878472), we evaluate a combination ICI (camrelizumab), antiangiogenesis (apatinib), chemotherapy (S-1 ± oxaliplatin) for treatment cancer. The primary endpoints are pathological responses...
Gastric cancer is not a single disease, and its subtype classification still evolving. Next-generation sequencing studies have identified novel genetic drivers of gastric cancer, but their use as molecular classifiers or prognostic markers disease outcome has yet to be established. In this study, we integrated somatic mutational profiles clinicopathologic information from 544 patients previous genomic identify significantly mutated genes (SMG) with relevance. were classified into regular...
Aims The purpose of our study was to determine whether mesenchymal stem cells (MSCs) are an effective and safe therapeutic agent for the treatment knee osteoarthritis (OA), owing their cartilage regeneration potential. Methods We searched PubMed, Embase, Cochrane Library, with keywords including “knee osteoarthritis” “mesenchymal cells”, up June 2019. selected randomized controlled trials (RCTs) that explored use MSCs treat OA. visual analogue scale (VAS), Western Ontario McMaster University...
Abstract Osteolysis caused by wear debris around the prosthesis is main reason for aseptic loosening. Extending prosthetic service life still challenging. In this study, we first synthesized a bone morphogenetic protein-2 (BMP-2) functional polypeptide (BMP2pp), and evaluated effects of BMP2pp on macrophage polarization impaired osteogenesis titanium (Ti) particles in vitro. Then, delineated impact formation resorption mouse calvarial osteolysis model induced Ti particles. The results showed...
Objective Elucidating complex ecosystems and molecular features of gallbladder cancer (GBC) benign diseases is pivotal to proactive prevention optimal therapeutic intervention. Design We performed single-cell transcriptome analysis on 230 737 cells from 15 GBCs, 4 cholecystitis samples, 3 polyps, 5 adenomas 16 adjacent normal tissues. Findings were validated through large-scale histological assays, digital spatial profiler multiplexed immunofluorescence (GeoMx), etc. Further mechanism was...
Mutant peptides presented by MHC (major histocompatibility complex) Class II in cancer are important targets for immunotherapy. Both animal studies and clinical trials patients showed that CD4 T cells specific to tumor-derived mutant essential the efficacy of immune checkpoint blockade therapy PD1 antibody. In this study, we analyzed next generation sequencing data 147 lung adenocarcinoma from The Cancer Genome Atlas predicted neoantigens I molecules. We found 18,175 expressed clonal somatic...
Neuroendocrine neoplasms (NENs) represent clinically and genetically heterogeneous malignancies, thus a comprehensive understanding of underlying molecular characteristics, prognostic signatures, potential therapeutic targets is urgently needed.Next-generation sequencing (NGS) immunohistochemistry were applied to acquire genomic immune profiles NENs from 47 patients.Difference was distinguished based on differentiation grade primary localization. Poorly differentiated neuroendocrine...
Osteoporosis is a negative balance of bone metabolism caused by the lower formation osteoblasts than absorption osteoclasts. Ferroptosis plays an important role in osteoporosis, but its effects on and osteoclasts are still unclear.First, we compared osteogenic differentiation potential MSCs osteoclast monocytes between osteoporosis mice control. Then, obtained gene expression profiles monocytes, screened differentially expressed genes for enrichment analysis. Next, cluster patients with...
Abstract There is a close relationship between immune‐mediated inflammation and cancer, there still controversy over whether rheumatoid arthritis (RA) increases the risk of malignancy. We first used Mendelian randomization (MR) analysis to explore potential causal RA pan‐cancer. And verify effect on cancer through intermediate MR analysis. Then we extracted standardized incidence rate malignancy in patients relative general population large‐scale meta‐analysis. Finally, performed pan‐cancer...
Abstract Background Neoantigen-based personal vaccines and adoptive T cell immunotherapy have shown high efficacy as a cancer treatment in clinical trials. Algorithms for the accurate prediction of neoantigens played pivotal role such studies. Some existing bioinformatics methods, MHCflurry NetMHCpan, identify mainly through peptide-MHC binding affinity. However, predictive accuracy immunogenicity these methods has been to be low. Thus, ranking algorithm select highly immunogenic patients is...
Due to the complex mechanisms affecting anti-tumor immune response, a single biomarker is insufficient identify patients who will benefit from checkpoint inhibitors (ICIs) treatment. Therefore, comprehensive predictive model urgently required predict response ICIs. A total of 162 non-small-cell lung cancer (NSCLC) undergoing ICIs treatment three independent cohorts were enrolled and used as training test (training cohort = 69, cohort1 72, cohort2 21). Eight genomic markers extracted or...
Spondyloarthritis (SpA) and rheumatoid arthritis (RA) are chronic autoimmune diseases, but they usually difficult to distinguish in the early stage of diseases. The purpose this study is explore differences immune mechanism diagnostic markers through bioinformatics analysis.First, microarray datasets from patients with SpA, RA normal controls were obtained Gene Expression Omnibus (GEO) database. differentially expressed genes (DEGs) between groups identified R software. Functional pathway...
Neoadjuvant chemoradiotherapy (nCRT) has become the standard treatment for patients with locally advanced rectal cancer (LARC). However, 20-40% of LARC show little to no response nCRT. Thus, comprehensively understanding tumor microenvironment (TME), which might influence therapeutic efficacy, and identifying robust predictive biomarkers is urgently needed. Pre-treatment biopsy specimens from were evaluated in detail through digital spatial profiling (DSP), public RNA sequencing datasets,...
Dynamic changes of the peripheral T cell receptor (TCR) and soluble receptors ligands (sRLs) have potential to be used as biomarkers monitor evolution immune system in tumor patients undergoing immunotherapy. These functional could predict response treatment with checkpoint inhibitors (ICIs) provide high-value information on function status cancer patients, thereby helping physicians make effective clinical decisions. We collected paired pre- post-treatment blood samples from 31 solid...
Background: Rheumatoid arthritis (RA) is a chronic systemic immune disease characterized by joint synovitis, but there are differences in clinical manifestations and serum test results among different patients. Methods: This bioinformatics study. We first obtained the gene expression profile of RA normal synovium from database, screened differentially expressed related genes for enrichment analysis. Subsequently, we classified into three subtypes unsupervised clustering profiles based on...
4061 Background: The prognosis of cT4a/bN+ gastric cancer (GC) is poor due to low R0 resection rate and frequent recurrence. We evaluated the feasibility, safety, efficacy a combination immunotherapy, anti-angiogenesis, chemotherapy for neoadjuvant/conversion treatment GC. Methods: Patients with T4a/bN+ GC were enrolled receive camrelizumab (200mg d1), apatinib (250mg d1-14), S-1 (50mg bid d1-10) ± oxaliplatin (85 mg/m 2 d1) at least cycles, followed by re-evaluation operation....
Ovarian serous cystadenocarcinoma (OV) is a fatal gynecologic cancer with five-year survival rate of only 46%. Resistance to platinum-based chemotherapy prevalent factor in OV patients, leading increased mortality. The platinum resistance driven by transcriptome heterogeneity and tumor heterogeneity. Studies have indicated that ovarian stem cells (OCSCs), which are chemoresistant help disease recurrence, enriched chemotherapy. Stem significant influence on the progression prognosis patients...
Knee osteoarthritis (OA) involves a variety of tissues in the joint. Gene expression profiles different are great importance order to understand OA.First, we obtained gene cartilage, synovium, subchondral bone, and meniscus from Expression Omnibus (GEO). Several datasets were standardized by merging removing batch effects. Then, used unsupervised clustering divide OA into three subtypes. The ontology pathway enrichment subtypes analyzed. CIBERSORT was evaluate infiltration immune cells...