A5101774547- Ion Channels and Receptors
- Biofuel production and bioconversion
- Microbial Metabolic Engineering and Bioproduction
- Plant Stress Responses and Tolerance
- Sugarcane Cultivation and Processing
- Ion channel regulation and function
- Bioactive Compounds and Antitumor Agents
- Plant nutrient uptake and metabolism
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Plant responses to water stress
- dental development and anomalies
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Microbial Inactivation Methods
- Monoclonal and Polyclonal Antibodies Research
- Plant Taxonomy and Phylogenetics
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Nanoplatforms for cancer theranostics
- Metabolism and Genetic Disorders
- Agriculture Sustainability and Environmental Impact
- vaccines and immunoinformatics approaches
- Anaerobic Digestion and Biogas Production
- Fatigue and fracture mechanics
Fujian Agriculture and Forestry University
2023-2025
Hebei Agricultural University
2024
First Affiliated Hospital of Zhengzhou University
2024
Ningbo University Affiliated Hospital
2023
Yangpu Hospital of Tongji University
2023
Jining Medical University
2023
Nanchang University
2018-2022
Southwest Medical University
2022
Tongji University
2021
Ritsumeikan Asia Pacific University
2020
Abstract The life cycle of genome builds spans interlocking pillars assembly, annotation, and comparative genomics to drive biological insights. While tools exist address each pillar separately, there is a growing need for integrate different project holistically. For example, approaches can provide quality control assembly or annotation; in turn, help identify artifacts that may complicate the interpretation comparisons. JCVI library versatile Python‐based offers suite excel across these...
Abstract Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally mediated hot and cold sensation to intracellular organellar primary ciliary signaling. Here we report a cryo-electron microscopy (cryo-EM) structure TRPC4 in its unliganded (apo) state an overall resolution 3.3 Å. The reveals unique architecture with long pore loop stabilized by disulfide bond. Beyond shared tetrameric six-transmembrane fold,...
Research reveals the structure of TRPC5 ion channel, a potential drug target kidney disease, depression and anxiety.
Transcriptional super-enhancers and the BET bromodomain protein BRD4 are emerging as critical drivers of tumorigenesis therapeutic targets. Characterized by substantial accumulation histone H3 lysine 27 acetylation (H3K27ac) signals at loci cell identity genes oncogenes, recognized, bound activated BRD4, resulting in considerable oncogene over-expression, malignant transformation, cancer proliferation, survival, tumor initiation progression. Small molecule compound BD1 BD2 inhibitors block...
JUJUNCAO (Cenchrus fungigraminus; 2n = 4x 28) is a Cenchrus grass with the highest biomass production among cultivated plants, and it can be used for mushroom cultivation, animal feed, biofuel production. Here, we report nearly complete genome assembly of reveal that an allopolyploid originated ∼2.7 million years ago (mya). Its consists two subgenomes, subgenome A shares high collinear synteny pearl millet. We also investigated evolution suggest ancestral karyotype split into B karyotypes...
SUMMARY Sugarcane is a crop that accumulates sucrose with high photosynthesis efficiency. Therefore, the feedback regulation of on crucial for improving sugarcane yield. Saccharum spontaneum and officinarum are two founding species modern hybrids. S. exhibits higher net photosynthetic rate but lower content than . However, mechanism underlying negative by remains poorly understood. This study investigates effects exogenous treatment Exogenous increases in leaf base inhibits efficiency...
Lung cancer is one of the most common malignant tumors. Despite decades research, treatment lung remains challenging. Non-small cell (NSCLC) primary type and a significant focus research in treatment. The deubiquitinase ubiquitin-specific protease 28 (USP28) plays role progression various tumors serves as potential therapeutic target. This study aims to determine USP28 NSCLC. We examined impact inhibitor AZ1 on cycle, apoptosis, DNA damage response, cellular immunogenicity non-small cancer....
Abstract Background Neoantigen-based personal vaccines and adoptive T cell immunotherapy have shown high efficacy as a cancer treatment in clinical trials. Algorithms for the accurate prediction of neoantigens played pivotal role such studies. Some existing bioinformatics methods, MHCflurry NetMHCpan, identify mainly through peptide-MHC binding affinity. However, predictive accuracy immunogenicity these methods has been to be low. Thus, ranking algorithm select highly immunogenic patients is...
Bcl-2-associated athanogene-1 (BAG-1) is a multifunctional anti-apoptotic protein which regulates an array of cellular processes, including apoptosis, signaling, proliferation, transcription, and cell motility has been reported to be over-expressed in number human malignancies. To investigate the possible involvement BAG-1 tumorigenesis hepatocellular carcinoma (HCC), we performed Western blot analysis eight paired samples HCC adjacent peritumoral tissues immunohistochemistry 65 paraffin...
Abstract Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally-mediated hot and cold sensation to intracellular organellar primary ciliary signaling. Structures belonging TRPV, TRPM, TRPP, TRPA TRPML subfamilies have been solved, but date, none founding canonical (TRPC) structures. Here we report an electron cryo-microscopy (cryo-EM) structure TRPC4 in its apo state overall resolution 3.3 Å. The reveals...
Rho GTPases play an essential role in many cellular processes, including cell cycle progress, motility, invasion, migration, and transformation. Several studies indicated that the dysregulation of GTPase signaling is closely related to tumorigenesis. GEFs considered being positive regulators GTPase, promoting dissociation protein from GDP binding GTP, thus activating downstream pathway. Herein, we demonstrated ARHGEF3, a member family, played important non-small lung cancer (NSCLC). We found...
With the development of sustainable agriculture, trials on benefits application organic fertilizers around world have been conducted. Herein, we investigated impact pure chemical (CFs) combined with compared CFs (100% CFs) and no (NFs) soil properties as well yield quality Chinese cabbage through meta-analysis. Results indicate that: (1) Compared NFs, can significantly improve increase nutrients. (2) CFs, fresh weight, number leaves, transverse diameter, leaf length, per plant, increases...
Metabolic flux analyses were performed based on the carbon balance of six different Lactobacillus strains used in this study. Results confirmed that L. delbrueckii, plantarum ATCC 21028, NCIMB 8826 Δ ldhL1 , ‐pCU‐P xylAB, and ‐pLEM415‐ xylAB metabolized glucose via EMP: whereas, brevis PK pathway. Xylose was through pathway brevis, . Operation both EMP pathways found when plus xylose as source. The information detailed flow may help strain biomass selection a designed process lactic acid...
Introduction: Ovarian cancer is one of the most common gynecological cancers worldwide. While, therapies against ovarian have not been completely effective, sinomenine has proved to anti-tumor activity in various cells. However, study its anti-ovarian effect still rare, and underlying mechanism elucidated. Therefore, we aim explore cancer. Materials Methods: The HeyA8 cells was analyzed by CCK8 colony formation assay. explored via high throughput RNA-seq, then target mRNA protein expression...
Members of the transient receptor potential (TRP) ion channels conduct cations into cells. They mediate functions ranging from neuronally-mediated hot and cold sensation to intracellular organellar primary ciliary signaling. Structures belonging TRPV, TRPM, TRPP, TRPA TRPML subfamilies have been solved, but date, none founding canonical (TRPC) structures. Here we report an electron cryo-microscopy (cryo-EM) structure TRPC4 in its apo state overall resolution 3.3 Angstrom. The reveals...
Abstract The transient receptor potential canonical subfamily member 5 (TRPC5) is a non-selective calcium-permeant cation channel. As depolarizing channel, its function studied in the central nervous system and kidney. TRPC5 forms heteromultimers with TRPC1, but also homomultimers. It can be activated by reducing agents through reduction of extracellular disulfide bond. Here we present 2.9 Å resolution electron cryo-microscopy (cryo-EM) structure TRPC5. apo state partially open, which may...
White-rot fungi are the only organisms that can completely degrade all components of lignocellulosic biomass, including recalcitrant lignin polymer. Lignin degradation is important for industrial application biomass as a raw material producing value-added chemicals and materials. Therefore, elucidating mechanism in white-rot will help researchers develop efficient eco-friendly methods enabling production from biomass. A transcriptome analysis an effective way to compare gene expression...
Circular agriculture is an inevitable trend in the sustainable development of global agriculture. At present, there are issues such as insufficient utilization resources, serious land pollution, and lack technical support circular agricultural ecological parks. This study explores safe application organic fertilizer to field crops within A peanut (Arachis hypogaea L.)–wheat (Triticum aestivum L.)–maize (Zea mays L.) crop rotation system was selected research methods biogas residues on...
Saccharum officinarum (S. officinarum) and spontaneum spontaneum) are two fundamental species of modern sugarcane cultivars, exhibiting divergent tillering patterns crucial for architecture yield. Strigolactones (SLs), a class plant hormones, considered to play central role in shaping form regulating tillering. Our study highlights the distinct observed between S. spontaneum, implicates significant differences SL levels root exudates species. Treatment with rac-GR24 (an artificial...