A5101713267- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Gynecological conditions and treatments
- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- T-cell and B-cell Immunology
- Silk-based biomaterials and applications
- Muscle and Compartmental Disorders
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- Lipid metabolism and disorders
- Magnesium in Health and Disease
- Genetic factors in colorectal cancer
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- Polysaccharides and Plant Cell Walls
- Protein Kinase Regulation and GTPase Signaling
- Hematopoietic Stem Cell Transplantation
- Adipokines, Inflammation, and Metabolic Diseases
Hubei University of Medicine
2025
Taihe Hospital
2025
Xi'an Jiaotong University
2023
Tongji University
2015-2021
Obstetrics and Gynecology Hospital of Fudan University
2021
Yangpu Hospital of Tongji University
2010-2018
Qilu Hospital of Shandong University
2009-2017
Celulose Beira Industrial (Portugal)
2014
Deleted Institution
2014
Selangor Business School
2014
Long noncoding RNA (lncRNA) profiles in ovarian cancer (OC) remain largely unknown. In the present study, we screened AB073614 as a new candidate lncRNA which promotes development of OC, two independent datasets (GSE18521 and GSE38666) from Gene Expression Omnibus (GEO). The level was then detected 75 paired OC tissues adjacent normal by qRT-PCR. Results showed that expression significantly up-regulated 85.3% (64/75) cancerous compared with counterparts (P < 0.01). Further, 5-year overall...
The present study tested whether the LPS/TLR4 signal pathway in endometrial stromal cells is essential for pathogenesis of adenomyosis. We expression TLR4, MD2 endometrium without adenomyosis (CE), eutopic with (EuE) and ectopic (EE). isolated from CE, EuE EE (CESC, EuESC, EESC), treated lipopolysaccharide (LPS) TLR4 antagonist detected cell viability. And we also measured key protein inflammatory proliferation invasive growth experimental cells. found that viability LPS was significantly...
Transmembrane protein 158 (TMEM158) is a recently identified upregulated gene during Ras-induced senescence. Its association with various cancers has been reported. However, the expression and biological function of TMEM158 in ovarian cancer still unclear. This study was aimed to elucidate roles cell proliferation, adhesion invasion cells.We analyzed mRNA level tissues adjacent no-tumorous by real-time PCR. We then suppressed cells RNA interference examined effects knockdown on cancerous...
Abstract STUDY QUESTION How does ectopic endometrial stromal cell (Ecto-ESC)-derived extracellular vesicular Legumain pseudogene 1 (EV-LGMNP1), a newly identified of (LGMN), contribute to M2-phenotype macrophage polarization, and it predict recurrence in patients with ovarian endometriosis (EMs)? SUMMARY ANSWER EV-LGMNP1, which is abundant Ecto-ESCs serum from EMs, can direct macrophages towards an M2 phenotype by upregulating LGMN expression promising biomarker for predicting EMs...
Ovarian cancer is the most lethal gynecologic malignancy worldwide. ETS homologous factor (EHF), a member of E26 transformation specific (ETS) transcription factors, has been reported overexpressed in ovarian cancer. However, molecular mechanism underlying biological function EHF still unclear. Here, we found that was elevated tissues compared with non-tumorous tissues. Moreover, high expression level correlated short survival time patients Knockdown cells, SKOV3 and OVCAR3, significantly...
In this study, we investigated the expression profiles of Toll-like receptors(TLRs) in eutopic endometrium(EU) and ectopic endometrium(EC) its implication inflammatory pathogenesis adenomyosis. Thirty adenomyosis patients who underwent laparoscopy were recruited study. We tested mRNA protein TLRs, IL-6 IL-8 EU EC patients, control endometrium without adenomyosis(CE). found that was significantly higher than CE, highest (P < 0.01). The TLRs EU, with TLR1-6, 8 9 being (except TLR6) 0.05 or P...
In the present study, expression levels of high‑mobility group protein B1 (HMGB1), Toll‑like receptor 4 (TLR4), nuclear factor (NF)‑κB and tumor necrosis (TNF)‑α in malignant epithelial ovarian cancer (MEOC) were investigated regards to several clinicopathological characteristics. A total 20 patients with MEOC who underwent surgery recruited study. The mRNA HMGB1, TLR4, NF‑κB TNF‑α was determined compared diagnosed benign cysts (BOC). It demonstrated that significantly increased, BOC...
This study aimed to investigate RhoA, RhoA-associated coiled-coil containing protein kinase (ROCK) 1, ROCK2, and Rho GTPase-activating 26 (ARHGAP26) expression in the eutopic endometrium (EU) ectopic (EC), examine their relationships with clinical characteristics of adenomyosis.Twenty patients adenomyosis who underwent laparoscopy were recruited. Protein mRNA ROCK1, ARHGAP26 EU EC control without (CE) was detected.ROCK1, RhoA significantly higher than that CE, highest EC. lower CE. gene...
To explore the value of serum levels CA125, platelet count (PLT), neutrophil–lymphocyte ratio (NLR), and modified CA125 markers CA125a CA125b in predicting pelvic dense adhesion (PDA) associated with adenomyosis, = lg(CA125 × PLT 109), NLR). This retrospective study included 304 patients who underwent surgery for adenomyosis. Correlations PLT, NLR, adenomyosis-derived PDA were analyzed by Logistic regression. Receiver operating characteristic curve was applied to assess utility these...
As the traditional Chinese medicine, fresh fruits of Amorpha fruticosa L. were applied for treatment carbuncle, eczema and burn (Das et al., 2007). However, little is known about functional roles during wound healing progress. In present study, we evaluated both antimicrobial potential against a wide range microorganisms activity seven compounds isolated from L in vitro vivo. Our results showed that I (6a,12a–dehydroamorphin), V (dehydrosermundone) VI (tephrosin) performed dominant...
The objective of the present study was to investigate differences in expression apoptosis-related factors eutopic and ectopic endometrium (EuE/EE) women with adenomyosis before after laparoscopic bilateral uterine artery occlusion (LUAO). Ten patients who received LUAO were selected as research subjects, from whom EuE EE tissues obtained detected for molecules by PT-PCR Western blot, changes mitochondrial structure electron microscopy. Normal endometrial stromal cells (NESC), EuE/EE cultured...
Myosin is involved in cell contraction and motility, but it unclear whether proliferation uterine myoma. In this study therefore we aimed to explore the role of myosin myoma.Immunohistochemistry real-time polymerase chain reaction were used determine expression light (MLC), heavy (MHC) kinase (MLCK) patient myoma adjacent smooth muscle tissue. Human fibroid cells isolated cultured vitro, 11 (MHC subtype expressed cells) was knocked down by RNA interference reduce myosin, then determined...
Introduction: Ovarian cancer is one of the most common gynecological cancers worldwide. While, therapies against ovarian have not been completely effective, sinomenine has proved to anti-tumor activity in various cells. However, study its anti-ovarian effect still rare, and underlying mechanism elucidated. Therefore, we aim explore cancer. Materials Methods: The HeyA8 cells was analyzed by CCK8 colony formation assay. explored via high throughput RNA-seq, then target mRNA protein expression...