A5035520117- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Uterine Myomas and Treatments
- Pelvic floor disorders treatments
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Ovarian cancer diagnosis and treatment
- Circular RNAs in diseases
- Hernia repair and management
- Minimally Invasive Surgical Techniques
- Anorectal Disease Treatments and Outcomes
- Pelvic and Acetabular Injuries
- Extracellular vesicles in disease
- Reproductive System and Pregnancy
- RNA Research and Splicing
- MicroRNA in disease regulation
- Reproductive Biology and Fertility
- Cancer Risks and Factors
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Pregnancy-related medical research
- Female Genital Mutilation/Cutting Issues
- Intraperitoneal and Appendiceal Malignancies
- Urological Disorders and Treatments
Obstetrics and Gynecology Hospital of Fudan University
2016-2025
Fudan University
2014-2024
Duke University
2024
Shanghai Medical College of Fudan University
2014-2023
State Key Laboratory of Oncogene and Related Genes
2020-2023
Women's Hospital, School of Medicine, Zhejiang University
2021
Ipsen (France)
2021
Shanghai Institute of Planned Parenthood Research
2019-2021
State Key Laboratory of Genetic Engineering
2021
Huazhong University of Science and Technology
2020
Exosomes mediate cell-cell crosstalk in cancer progression by transferring their molecular cargos, including long noncoding RNAs (lncRNAs).Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a well-known lncRNA associated with angiogenesis and metastasis.However, the presence of MALAT1 exosomes roles clinical values exosomal epithelial ovarian (EOC) remain unknown.The present study focused on between EOC cells endothelial mediated aimed to explore reveal relevance prognostic...
Recent studies have highlighted the role of long non-coding RNAs (lncRNAs) in carcinogenesis and suggested that genes this class might be used as biomarkers cancer. However, whether lncRNAs are involved serous ovarian cancer (SOC) remains largely unknown. In present study, we focused on lncRNA antisense RNA INK4 locus (ANRIL) investigated its expression pattern, clinical significance, biological function SOC. We found ANRIL levels were elevated SOC tissues compared with normal controls...
Cervical cancer (CC) is the most common gynecological malignancy, whose cellular heterogeneity has not been fully understood. Here, we performed single-cell RNA sequencing (scRNA-seq) to survey transcriptomes of 57,669 cells derived from three CC tumors with paired normal adjacent non-tumor (NAT) samples. Single-cell transcriptomics analysis revealed extensive in malignant human CCs, wherein epithelial subpopulation exhibited different genomic and transcriptomic signatures. We also...
Novel therapies are needed to treat recurrent and advanced cervical cancer (CC), as their prognosis remains very poor. Although targeting the programmed cell death protein 1 (PD-1) pathway have been approved for CC, a large subset of patients exhibit innate resistance. Using checkpoint inhibitors in combination could enhance efficacy.Blood samples, tumor specimens, peritumorous (PT) tissues were obtained from with CC. The inhibitory receptor expression phenotypical analysis CD8+ T cells CC...
Abstract Background The mechanism underlying cervical carcinogenesis that is mediated by persistent human papillomavirus (HPV) infection remains elusive. Aims Here, for the first time, we deciphered both temporal transition and spatial distribution of cellular subsets during disease progression from normal cervix tissues to precursor lesions cancer. Materials & Methods We generated scRNA‐seq profiles transcriptomics data nine patient samples, including two HPV‐negative normal,...
Cervical adenocarcinomas (ADCs), including human papillomavirus (HPV)-associated (HPVA) and non-HPVA (NHPVA), though exhibiting a more malignant phenotype poorer prognosis, are treated identically to squamous cell carcinoma (SCC). This clinical dilemma requires deeper investigation into their differences. Herein transcriptomic atlas of SCC, HPVA, NHPVA-ADC using single-cell RNA (scRNA) T-cell receptor sequencing (TCR-seq) is presented. Regarding structural cells, the malignancy origin...
Abstract Background Cervical cancer (CC) is the fourth most common in women worldwide. Although immunotherapy has been applied clinical practice, its therapeutic efficacy remains far from satisfactory, necessitating further investigation of mechanism CC immune remodeling and exploration novel treatment targets. This study aimed to investigate explore potential Methods We conducted single‐cell RNA sequencing on a total 17 specimens, including normal cervical tissues, high‐grade squamous...
// Jun-jun Qiu 1, 2, 3 , Yan Wang 4, 5 Ying-lei Liu 6 Ying Zhang Jing-xin Ding Ke-qin Hua 1 Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China 2 Shanghai Medical College, Key Laboratory Female Reproductive Endocrine-Related Diseases, 4 Cancer Institute, Oncology, The Second Affiliated Hospital Nantong Nantong, Correspondence to: Hua, email: huakeqin@126.com Keywords: ANRIL, proliferation, cell cycle, apoptosis, senescence Received: September 03,...
Could human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Ex) accelerate vaginal epithelium cell (VK2) growth?HucMSC-Ex play a significant role in promoting proliferation of VK2 cells by accelerating the cycle and inhibiting apoptosis through exosomal microRNAs vitro.Numerous studies have reported that MSC-Ex an important tissue injury repair.hucMSC isolated from their conditioned medium were used to treat epithelial line (VK2). Normal fibroblasts (HFF-1) as negative control...
Background: Homologous recombination deficiency (HRD) is a common molecular characteristic of genomic instability, and has been proven to be biomarker for target therapy. However, until now, no research explored the changes in transcriptomics landscape HRD tumors. Methods: The score was established from SNP array data breast cancer patients genome atlas (TCGA) database. transcriptome with different scores were analyzed identify biomarkers associated HRD. candidate validated gene expression...
Ovarian carcinoma is one of the most common gynecologic malignancies, cisplatin resistance has become a key obstacle to successful treatment ovarian cancer because carcinomas are liable drug resistance. To find an effective carrier urgent need.Exosomes and loading-cisplatin exosomes isolated using differential centrifugation characterized by transmission, electron, nanoparticle tracking analysis. The anti-cancer effect was detected under circumstance delivered or without in vitro vivo. Using...
PD-1 blockade is a first-line treatment for recurrent/metastatic cervical cancer but benefits only small number of patients due to low preexisting tumor immunogenicity. Using immunogenic cell death (ICD) inducers promising strategy improving immunotherapy, these compounds are limited by the hypoxic environment solid tumors. To overcome this issue, nanosensitizer AIBA@MSNs were designed based on sonodynamic therapy (SDT), which induces under conditions through azo free radicals in method...