A5100322817- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- RNA Research and Splicing
- Nanoparticle-Based Drug Delivery
- Epigenetics and DNA Methylation
- Flavonoids in Medical Research
- Esophageal and GI Pathology
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Cancer survivorship and care
Harbin Medical University
2013-2025
Sun Yat-sen University
2015-2025
Peking University
2013-2025
Peking University Cancer Hospital
2013-2025
Shanghai University of Traditional Chinese Medicine
2019-2025
Shanghai Medical College of Fudan University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Shuguang Hospital
2019-2025
Southwest Medical University
2025
Cold Spring Harbor Laboratory
2025
To evaluate sintilimab versus placebo in combination with chemotherapy (cisplatin plus paclitaxel or cisplatin 5-fluorouracil) as first line treatment of unresectable locally advanced, recurrent, metastatic oesophageal squamous cell carcinoma.Multicentre, randomised, double blind, phase 3 trial.66 sites China and 13 outside between 14 December 2018 9 April 2021.659 adults (aged ≥18 years) advanced carcinoma who had not received systemic treatment.Participants were randomised 1:1 to receive...
Abstract Extracellular vesicles have emerged as important mediators of intercellular communication in cancer, including by conveying tumor-promoting microRNAs between cells, but their regulation is poorly understood. In this study, we report the findings a comparative microRNA profiling and functional analysis human glioblastoma that identifies miR-1 an orchestrator extracellular vesicle function growth invasion. Ectopic expression cells blocked vivo growth, neovascularization, invasiveness....
The gut microbiome is involved in antitumor immunotherapy and chemotherapy responses; however, evidence-based research on the role of predicting response to neoadjuvant chemoradiotherapy (nCRT) patients with locally advanced rectal cancer (LARC) remains scarce. This prospective, longitudinal study aimed evaluate feasibility nCRT responses.We collected 167 fecal samples from 84 LARC before after 31 specimens healthy individuals for 16S rRNA sequencing. Patients were divided into responders...
Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental with male-to-female prevalence of 4:1. However, the genetic mechanisms underlying this gender difference remain unclear. Mutation burden analysis, TADA model, and co-expression functional network analyses were performed on de novo mutations (DNMs) corresponding candidate genes. We found that putative DNMs (loss-of-function predicted deleterious missense mutations) in females was significantly higher than males,...
Esophageal squamous cell carcinoma (ESCC) ranks fourth among cancer-related deaths in China due to the lack of actionable molecules. We performed whole-exome and T-cell receptor (TCR) repertoire sequencing on multi-regional tumors, normal tissues blood samples from 39 ESCC patients. The data revealed 12.8% ERBB4 mutations at patient level functional study supported its oncogenic role. 18% patients with early BRCA1/2 variants were associated high-level contribution signature 3, which was...
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, can be secreted by most cell types released in perhaps all biological fluids. EVs contain multiple proteins, specific lipids several kinds of nucleic acids such as RNAs DNAs. Studies have found that double-stranded DNA genetic information has a certain degree consistency with tumor DNA. Therefore, if genes exist exosomes are stable, we may able to use testing new means monitor gene mutation.In this study,...
Breast cancer is the most common in women worldwide. Cancer-secreted exosomes have recently been recognized as important mediators of intercellular communication. The aim this study was to determine role exosomal long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) breast progression.Breast specimens were obtained with informed consent from patients. Quantitative real-time polymerase chain reaction (qRT-PCR) used detect MALAT1 expression, and cellular...
Increasing evidence suggests that the gut microbiota plays vital roles in metabolic diseases. Polygonatum odoratum extract alleviates hyperglycemia and hyperlipidemia, but underlying mechanism remains unclear. This study investigated effects of P. polysaccharides (POPs) on high-fat diet (HFD)-induced obesity rats whether these were related to modulation microbiota. POP treatment attenuated weight gain, fat accumulation, epididymal adipocyte size, liver triglycerides, total cholesterol...
Long noncoding RNAs (lncRNAs) play important roles in the development and progression of human cancers. The lncRNA prostate cancer-associated transcript 1 (PCAT1) has been reported to be involved multiple cancers, including oesophageal squamous cell carcinoma (ESCC). However, detailed biological functions, underlying mechanisms clinical relevance PCAT1 ESCC remain unclear. Here, we confirmed that was highly expressed tissues lines. Knockdown inhibited growth cells, whereas overexpression...
BackgroundCirculating tumor DNA (ctDNA) isolated from plasma contains genetic mutations that can be representative of those found in primary tissue DNA. These samples provide insights into tumoral heterogeneity patients with advanced gastric cancer (AGC). Although trastuzumab has been shown to effective first-line therapy for metastatic overexpression human epidermal growth factor receptor 2 (HER2), the mechanism AGC resistance is incompletely understood.MethodsIn this prospective study, we...
Mesenchymal stem cell-derived exosomes (MSC-Exos) have potential as drug-delivery vehicles and exhibit great promise for hepatocellular carcinoma (HCC) therapy. Here, we consider bone mesenchymal (BMSC-Exos) drug carriers to encase anticancer norcantharidin (NCTD) explore their therapeutic effects against HCC. NCTD was loaded into purified from BMSCs via electroporation, an in vitro release study showed that BMSC-Exos-NCTD provided a continuous slow of the drug. A series vivo pharmacodynamic...
Preoperative neoadjuvant chemoradiotherapy (nCRT) is a standard treatment for locally advanced rectal cancer (LARC) patients, yet little known about the mediators underlying heterogeneous patient response. In this longitudinal study, we performed 16S rRNA sequencing on 353 fecal specimens and find reduced microbial diversity after nCRT. Multi-omics data integration reveals that Bacteroides vulgatus-mediated nucleotide biosynthesis associates with nCRT resistance in LARC nonresponsive tumors...
Abstract Indolent (lepidic) and aggressive (micropapillary, solid, poorly differentiated acinar) histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but the molecular features associated with different their transitions remain elusive. Here, we combine spatial transcriptomics multiplex immunohistochemistry to elucidate characteristics cellular plasticity distinct LUAD. We delineate transcriptional reprogramming dynamic cell signaling that determine subtype...
Remimazolam (Rema) is a novel anesthetic that widely used in anesthesia and sedation critically ill patients. Notably, Rema exerts effects patients through activation of the γ‑aminobutyric acid (GABA) receptor. GABA may alleviate myocardial ischemia/reperfusion (I/R) injury; however, impact underlying molecular mechanism I/R injury remain to be fully understood. Therefore, present study aimed investigate on cardiac determine mechanisms. An acute model was established by ligating left...
The existence of many highly similar genes in the lymphocyte receptor gene loci makes them difficult to investigate, and determination phased "haplotypes" has been particularly problematic. However, V(D)J rearrangements provide an opportunity infer association Ig along chromosomes. chromosomal distribution H chain genotype can be inferred through analysis VDJ individuals who are heterozygous at points within IGH locus. We analyzed from 44 for whom sufficient unique were available allow...
// Jun-jun Qiu 1, 2, 3 , Yan Wang 4, 5 Ying-lei Liu 6 Ying Zhang Jing-xin Ding Ke-qin Hua 1 Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China 2 Shanghai Medical College, Key Laboratory Female Reproductive Endocrine-Related Diseases, 4 Cancer Institute, Oncology, The Second Affiliated Hospital Nantong Nantong, Correspondence to: Hua, email: huakeqin@126.com Keywords: ANRIL, proliferation, cell cycle, apoptosis, senescence Received: September 03,...
MicroRNAs (miRNAs) have been found to play important regulatory roles in various physiological and pathological processes. MiRNAs also exhibit high stability are present at concentrations human bodily fluids. Consequently, miRNAs may represent attractive novel diagnostic biomarkers for certain clinical conditions. Recently, the capacity extracellular vesicles, including microvesicles exosomes, carry that participate cell-to-cell communication has described. In study, miRNA expression...
Previous studies on the mechanisms underlying ESCC (esophageal squamous cell carcinoma) chemoresistance only focused tumor cells while microenvironment has been completely ignored. Our study aimed to clarify effect of CAFs (cancer-associated fibroblasts), one major component microenvironment, ESCC. By primary culture, two pairs and matched NFs (normal fibroblasts) were isolated from tissues patients normal esophageal epithelial tissues, respectively. The association was assessed in carcinoma...
The Hippo signaling pathway is a critical regulator of organ size control during development, and its deregulation associated with cancers. Acting downstream this pathway, Yes-associated protein (YAP) was implicated in tumorigenesis. present study aimed to explore the expression patterns clinical significance YAP human colorectal cancer (CRC). In addition, we investigated relationship between Wnt/β-catenin activation CRC. A total 139 cases CRC tissues were by immunohistochemistry for YAP,...
Obesity leads to colonic inflammation and may increase the risk of colorectal cancer. Xylooligosaccharide (XOS) exhibits strong antioxidant excellent antibacterial properties, can be utilized by gut microbes maintain ecological balance intestinal tract. In this study, we explored how XOS modulates microbiota regulates high fat diet (HFD) induced inflammation. We measured changes in body weight visceral coefficients rats fed a high-fat diet. also expression levels inflammatory factors plasma...