A5100754465- Laser Applications in Dentistry and Medicine
- Lipid Membrane Structure and Behavior
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer-related molecular mechanisms research
- Carbohydrate Chemistry and Synthesis
- Genetics, Aging, and Longevity in Model Organisms
- Tryptophan and brain disorders
- Biosensors and Analytical Detection
- Hepatitis C virus research
- Speech and Audio Processing
- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
- Speech Recognition and Synthesis
- Risk and Portfolio Optimization
- Natural product bioactivities and synthesis
- Music and Audio Processing
- Endoplasmic Reticulum Stress and Disease
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Supramolecular Self-Assembly in Materials
- Optimization and Variational Analysis
- Photodynamic Therapy Research Studies
- Vibrio bacteria research studies
Toho University
2020-2025
Guangzhou Medical University
2025
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2025
Chonnam National University
2021-2024
State Key Laboratory of Food Science and Technology
2022-2024
Nanchang University
2022-2024
Obstetrics and Gynecology Hospital of Fudan University
2022-2023
First Affiliated Hospital of Henan University
2023
Yanbian University
2023
Yanbian University Hospital
2023
Cervical cancer (CC) is the most common gynecological malignancy, whose cellular heterogeneity has not been fully understood. Here, we performed single-cell RNA sequencing (scRNA-seq) to survey transcriptomes of 57,669 cells derived from three CC tumors with paired normal adjacent non-tumor (NAT) samples. Single-cell transcriptomics analysis revealed extensive in malignant human CCs, wherein epithelial subpopulation exhibited different genomic and transcriptomic signatures. We also...
Previous studies have revealed antibody to hepatitis B core antigen (anti-HBc) levels as a predictor of treatment response in early (HBeAg)-positive chronic (CHB) patients both interferon and nucleos(t)ide analog therapy cohorts. However, there is no information about anti-HBc the natural history CHB. This study aimed define different phases Two hundred eleven treatment-naive CHB were included study. They classified into 4 phases: immune tolerance (IT) phase (n = 39), clearance (IC) 48), low...
Abstract Cervical squamous cell carcinoma (SCC) and adenocarcinoma (AD) are the main histological types of human papillomavirus‐related cervical cancer. However, there few reports on type‐specific molecular differences between SCC AD. Here, we used unbiased droplet‐based single‐cell RNA sequencing to elucidate cellular AD in tumor heterogeneity, microenvironment (TME). A total 61 723 cells from three patients, were collected divided into nine types. Epithelial exhibited high intra‐...
Metallic molybdenum (Mo) has been increasingly recognized as a potential biodegradable metal for biomedical implants. However, the macrophage-mediated inflammatory responses to Mo-based implants remain underexplored. This study examined in vitro reactions of macrophages degradation products Mo The short-term and long-term biodegradation behavior subsequent impact on cytotoxicity, metabolism, macrophage polarization were assessed. Both its shown be non-toxic within tolerance limits....
The Silene genus plants in the Caryophyllaceae family are a large with over 850 species. It has been known that contain triterpenoid saponins. These saponins have glucuronic acid sugar chain and difficult to separate chromatography. In this study, strategy was developed clarify distribution of whole vulgaris by isolation neutralized using methylation reactions, which were used as standard substances for LC-MS analysis, elucidating their characteristic MS MS/MS fragment patterns. n-butanol...
Azobenzene-contained glycolipids GlyAzoCns, newly structured azobenzene derivatives, which have an moiety between the galactosyl and carbon chains of various sizes, been synthesized. The GlyAzoCns undergo reversible photoinduced isomerization in both ethanol solution (free state) liposomal bilayer (restricted upon irradiation with UV vis light alternately. drug release Liposome@Gly induced by was found to be instantaneous behavior. control DOX from liposome investigated modes. Liposome@Glys...
A smart dendrigraft poly-l-lysine (DGL) nanoplatform for mitochondria-targeted chemotherapy was devised, which aims to achieve enhanced efficacy against drug resistant tumor cells. In this system, doxorubicin (Dox) intercalated into the DNA duplex containing an ATP aptamer, subsequently condensed by DGL form a nanoscaled controlled-release system. nucleolin-specific binding AS1411, and cytochrome c aptamer were then incorporated system give nanoparticles (Dox/Mito-DGL) biological...
Psoriasis is a malignant skin disease characterized as keratinocyte hyperproliferation and aberrant differentiation. Our previous work reported that bibenzyl compound, erianin, has potent inhibitory effect on proliferation. To improve its poor water-solubility, increase anti- proliferation activity, enhance the delivery, erianin loaded dendritic mesoporous silica nanospheres (E/DMSNs) were employed.In this work, DMSNs with pore size of 3.5 nm (DMSN1) 4.6 (DMSN2) fabricated E/DMSNs showed...
Microfluidic chip-integrated capacitive bioplatform-based three-dimensional (3D) interdigital electrode arrays were proposed to achieve on-site continuous monitoring of cardiac- and periodontitis-related biomarkers with high sensitivity.
For this investigation, Caenorhabditis elegans (C. elegans) served, for the first time, as a model organism to evaluate toxic effect and possible underlying mechanisms under acrolein (ACR) exposure. The results showed that ACR exposure (12.5-100 μM) shortened lifespan of C. elegans. reproductive capacity, body length, width, locomotive behavior (head thrash) were diminished by ACR, especially doses 50 100 μM. Furthermore, significantly enhanced endogenous ROS levels elegans, inhibited...
Cervical cancer (CC) is one of the most frequent female malignancies worldwide. However, molecular mechanism lymph node metastasis in CC remains unclear. In this study, we investigated transcriptome profile 51,507 single cells from primary tumors, positive nodes (P-LN), and negative (N-LN) using single-cell sequencing. Validation experiments were performed bulk transcriptomic datasets immunohistochemical assays. Our results indicated that epithelial metastatic LN associated with cell-...
This work presents a novel attempt at using statistical modeling approach to predict the desalination performance of CDI.
Abstract An enhanced pseudotargeted method using a segment data‐dependent acquisition mode based on ultra‐high performance liquid chromatography–tandem mass spectrometry was developed. This data dependent acquisition‐based could improve the detection of co‐eluted ions and extend coverage analytes. A set 502 multiple reaction monitoring channels were obtained by this strategy, which twice number created traditional mode. Compared with untargeted method, profiling demonstrated higher...
In this study, it was found that epigallocatechin-3-gallate (EGCG) could extend the lifespan of Caenorhabditis elegans (C. elegans) induced by 100 μM acrolein (ACR) at all test concentrations (300, 400, 500, 600, and 700 μM). Notably, 500 EGCG exhibited most significant mean extension, increasing approximately 32.5%. Furthermore, effectively reduced elevated levels reactive oxygen species (ROS) lipofuscin production caused acrolein. It also bolstered activity antioxidant enzymes mitigated...
Emergency medicine is a 'high risk' specialty. Some diseases develop suddenly and progress rapidly, sudden unexpected deaths in the emergency department (ED) may cause medical disputes. We aimed to assess discrepancies between antemortem clinical diagnoses postmortem autopsy findings concerning dispute cases figure out most common major missed diagnoses.Clinical files reports were retrospectively analysed interpreted. Discrepancies evaluated using modified Goldman classification as minor...
Periodontitis is a common inflammatory disease that strongly influenced by dietary habits. Coffee one of the most components; however, current research on relationship between coffee consumption and periodontitis, as well its underlying mechanisms, limited. Based previous report, caffeine (CA) chlorogenic acid (CGA) were formulated into artificial (AC) for this experiment. Cell viability, prostaglandin E2 release, Western blotting, cellular reactive oxygen species (ROS) production,...
A quadruplex loop-mediated isothermal amplification (LAMP) method was developed to detect four Vibrio species, including ichthyoenteri, parahaemolyticus, scophthalmi, and vulnificus, simultaneously. Four sets of species-specific primers were designed with different restriction sites contained in the inner primers. The LAMP could distinguish species via subsequent enzyme analysis. sensitivity 10(2)-10(3) times higher than conventional PCR. V. parahaemolyticus ichthyoenteri be detected tissues...