A5100338318- Immune Cell Function and Interaction
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- T-cell and B-cell Immunology
- interferon and immune responses
- Cancer-related molecular mechanisms research
- Stroke Rehabilitation and Recovery
- Immune cells in cancer
- Soft tissue tumor case studies
- Sirtuins and Resveratrol in Medicine
- Endodontics and Root Canal Treatments
- Immune Response and Inflammation
- Dermatology and Skin Diseases
- Tumors and Oncological Cases
- Dental materials and restorations
- Spine and Intervertebral Disc Pathology
- Lymphoma Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Genomics, phytochemicals, and oxidative stress
- Medical Imaging and Analysis
- Genomic variations and chromosomal abnormalities
- Photodynamic Therapy Research Studies
Chonnam National University
2015-2024
National Institutes of Health
2014-2023
Chonnam National University Hospital
2010-2023
Jeonbuk National University
2023
UMass Memorial Health Care
2022
University of Massachusetts Chan Medical School
2022
Regeneron (United States)
2022
Vanderbilt Health
2021
Vanderbilt University
2018-2021
Virginia Tech
2021
Myeloid-derived suppressor cells (MDSC) play a key immunosuppressive role in various types of cancer, including head and neck squamous cell carcinoma (HNSCC). In this study, we characterized CD14+HLA-DR–/lo sorted from the tumors, draining lymph nodes, peripheral blood HNSCC patients. were phenotyped as CD11b+, CD33+, CD34+, arginase-I+, ROS+. all 3 compartments, they suppressed autologous, antigen-independent T proliferation differential manner. The abundance MDSC correlated with stage, but...
Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated obesity and an increased risk colorectal cancer. Whether HFCS contributes directly to tumorigenesis unclear. We investigated the effects daily oral administration in adenomatous polyposis coli (APC) mutant mice, which are predisposed develop intestinal tumors. The HFCS-treated mice showed a substantial increase tumor size grade absence metabolic syndrome. concentrations fructose glucose lumen...
Patients with head and neck squamous cell carcinoma harbor T cell-inflamed non-T tumors. Despite this, only 20% of patients respond to checkpoint inhibitor immunotherapy. Lack induction innate immunity through pattern-recognition receptors, such as the stimulator interferon (IFN) genes (STING) receptor, may represent a significant barrier development effective antitumor immunity. Here, we demonstrate robust control (MOC1), but not (MOC2), model cancer by activation STING pathway synthetic...
Abstract Aim Among numerous constituents of Panax ginseng , a constituent named Ginsenoside Rb1 (G‐Rb1) has been studied to diminish inflammation associated with diseases. This study investigated the anti‐inflammatory properties G‐Rb1 on human dental pulp cells (hDPCs) exposed lipopolysaccharide (LPS) and aimed determine underlying molecular mechanisms. Methodology The KEGG pathway analysis was performed after RNA sequencing in G‐Rb1‐ LPS‐treated hDPCs. Reverse‐transcription polymerase chain...
Ventilation decreases at sleep onset. This change is initiated abruptly α-θ electroencephalographic transitions. The aim of this study was to determine the contributions reduced activity in respiratory pump muscles and upper airway dilator change. Surface electromyograms over diaphragm (Di) intercostal fine-wire intramuscular electrodes genioglossus (GG) tensor palatini (TP) were recorded nine healthy young men. It shown that phasic Di both tonic TP activities lower during θ than α activity....
Trunk instability is one of main problems in survivors following stroke. We investigated the effects weight-shift training (WST) on an unstable surface sitting position trunk control, proprioception, and balance individuals with chronic hemiparetic Eighteen participants stroke were recruited allocated to either WST or control group. The group received a program for 30 min then conventional exercise min, while 60 five times week four weeks both groups. In this randomized study, we used three...
Objective: This study examined the effects of treadmill training with optic flow on functional recovery balance and gait in stroke patients. Design: Randomized controlled experimental study. Participants: Thirty patients following were divided randomly into group ( n = 10), 10) control 10). Interventions: The subjects wore a head-mounted display to receive speed-modulated during for 30 minutes, while those received regular therapy same time, three times week four weeks. Main measures: data...
Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination on responses CTLA-4 inhibition.Murine syngeneic carcinoma immune infiltrates were characterized by flow cytometry. Granulocytic MDSCs (gMDSCs) depleted T-lymphocyte antigen-specific measured. Tumor-bearing mice treated depletion blockade. Immune signatures within human HNSCC datasets from...
Background: Motor relearning protocols should involve task-oriented movement, focused attention, and repetition of desired movements. Objectives: To investigate the effect intensive gait training with rhythmic auditory stimulation on postural cont
Breast cancer is highly aggressive and the leading cause of cancer-related mortality in women developed countries. The ETS proto-oncogene 1 (Ets1) has versatile roles during cellular processes development. It often expressed breast cancers mediates migration invasion human cells. However, underlying mechanisms Ets1 gene expression still ambiguous. Here, we identified a core-regulatory element (CRE) located promoter region (-540/-80 bp from TSS) that contains elements responsible for...
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural compound found in large quantities, most notably grapes and red wine, which has been shown to have anti-inflammatory, chemopreventive anti-angiogenic effects. We examined whether resveratrol any effect on growth gene expression the human ovarian cancer PA-1 cells. show that inhibits cell induces apoptosis also investigated of changes global during resveratrol-induced inhibition cells using cDNA microarray with 7,448...
Abstract Objectives: Emerging evidence implicates the SNAIL family of transcriptional repressors in cancer development; however, role colorectal has not been established. To investigate importance carcinogenesis, we examined phenotypic and cellular consequences down-regulation MIN mouse. Methods: Twenty-eight male mice were randomized to treatment with an antisense phosphorodiamidate morpholino oligomer (AS-PMO) SNAIL, saline, or a scrambled sequence control for 6 weeks. Tumors scored...
Aims Granular cell tumours ( GCT s) are uncommon in the gastrointestinal tract, particularly colorectum. Herein, we report a series of 30 colorectal s and discuss properties based on histopathological immunohistochemical studies. Methods results Searching surgical pathology files identified cases for 2005–2013. A broad panel antibodies including neural macrophage markers were used evaluation. Colorectal predominantly involved right colon showed increased nuclear atypia pleomorphism...
Bone homeostasis is tightly regulated to balance bone formation and resorption. Many anabolic drugs are used as bone-targeted therapeutic agents for the promotion of osteoblast-mediated or inhibition osteoclast-mediated Previous studies showed that ginsenoside Re has effect suppression osteoclast differentiation in mouse bone-marrow derived macrophages zebrafish. Herein, we investigated whether affects osteoblast mineralization vitro vivo models. Mouse precursor MC3T3-E1 cells were...
This study investigated the influence of curing mode (dual- or self-cure) on surface energy and sorption/solubility four self-adhesive resin cements (SARCs) one conventional cement. The degree conversion (DC) parameters including hydrophilicity (DH) were determined using Fourier transform infrared spectroscopy contact angle measurements, respectively (n = 5). Sorption solubility assessed by mass gain loss after storage in distilled water lactic acid for 60 days A linear regression model was...
Abstract The Genome in a Bottle Consortium (GIAB), hosted by the National Institute of Standards and Technology (NIST), is developing new matched tumor-normal samples, first to be explicitly consented for public dissemination genomic data cell lines. Here, we describe comprehensive dataset from individual, HG008, including DNA an adherent, epithelial-like pancreatic ductal adenocarcinoma (PDAC) tumor line (HG008-T) normal cells duodenal tissue (HG008-N-D) (HG008-N-P). come thirteen whole...
Modulation of the immune system by cancer protective food bioactives has preventive and therapeutic importance in prostate cancer, but mechanisms remain largely unclear. The current study tests hypothesis that diet-derived compounds, indole-3-carbinol (I3C) 3,3′-diindolylmethane (DIM), affect tumor microenvironment regulation inflammatory responses monocytes macrophages. We also ask whether I3C DIM act through aryl hydrocarbon (AHR)-dependent pathway or signaling lymphocyte activation...
The insulin-like growth factor (IGF) pathway is thought to play an important role in brain development. Altered levels of IGFs and their signaling regulators have been shown autism spectrum disorder (ASD) patients. In this study, we investigated whether coding region single-nucleotide polymorphisms (cSNPs) the insulin receptor substrates (IRS1 IRS2), key mediators IGF pathway, were associated with ASD Korean males. Two cSNPs (rs1801123 IRS1, rs4773092 IRS2) genotyped using direct sequencing...
ETS1 has shown dichotomous roles as oncogene and tumor suppressor gene in diverse cancers, but its functionality breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of human (BRCA) patients by investigating expression patterns methylation status relation clinical prognosis. was significantly diminished hyper-methylation on promoter region specimens from BRCA compared healthy control. Moreover, ETS1high...