A5061227402- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Immune cells in cancer
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- RNA and protein synthesis mechanisms
- Dermatology and Skin Diseases
- Cancer Research and Treatments
- Cholesterol and Lipid Metabolism
- Genomics and Chromatin Dynamics
- Cytokine Signaling Pathways and Interactions
- Antioxidant Activity and Oxidative Stress
- Probiotics and Fermented Foods
- CAR-T cell therapy research
- RNA Research and Splicing
- Pharmacological Effects of Natural Compounds
- NF-κB Signaling Pathways
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lymphoma Diagnosis and Treatment
- Fungal and yeast genetics research
- Neuropeptides and Animal Physiology
- Atherosclerosis and Cardiovascular Diseases
ShanghaiTech University
2022-2024
Pohang University of Science and Technology
2018-2024
SAIC-GM (China)
2024
Institute for Basic Science
2015-2020
Memorial Sloan Kettering Cancer Center
2009-2013
Howard Hughes Medical Institute
2009-2013
Kettering University
2013
University of Washington
2009
Albert Einstein College of Medicine
2004-2007
St Bartholomew's Hospital
1985-1989
Distinct classes of protective immunity are guided by activation STAT transcription factor family members in response to environmental cues. CD4+ regulatory T cells (T(regs)) suppress excessive immune responses, and their deficiency results a lethal, multi-organ autoimmune syndrome characterized helper 1 (TH1) 2 (TH2) cell-dominated lesions. Here we show that pathogenic TH17 responses mice also restrained T(regs). This suppression was lost upon T(reg)-specific ablation Stat3, critical for...
Rational combinatorial therapeutic strategies have proven beneficial for the management of cancer. Recent success checkpoint blockade in highly immunogenic tumors has renewed interest immunotherapy. Regulatory T (T reg) cells densely populate solid tumors, which may promote progression through suppressing anti-tumor immune responses. We investigated role reg murine mammary carcinogenesis using an orthotopic, polyoma middle-T antigen-driven model Foxp3DTR knockin mice. cell ablation resulted...
Cell wall components of probiotic bacterium Bifidobacterium bifidum drive induction regulatory T cells in the gut.
Cells grow; cells divide. Some grow without dividing: neurons, or oocytes. divide growing: developing zygotes. For most cells, however, growth and division are coupled, thereby maintaining cell size within narrow limits. The basis of this coupling has been elusive. Cell was the subject some earliest molecular biological investigations when it shown that, on a variety media, ribosome content Escherichia coli proportional to rate (Maaloe Kjeldgaard 1966). Soon thereafter, study overshadowed by...
It has become clear that in Saccharomyces cerevisiae the transcription of ribosomal protein genes, which makes up a major proportion total by RNA polymerase II, is controlled interaction three factors, Rap1, Fhl1, and Ifh1. Of these, only Rap1 binds directly to DNA Ifh1 absent when repressed. We have examined further nature this find actually associated with at least two complexes. In addition its association forms complex (CURI) casein kinase 2 (CK2), Utp22, Rrp7. Fhl1 loosely CURI complex;...
Yeast is an integral part of mammalian microbiome, and like commensal bacteria, has the potential being harnessed to influence immunity in clinical settings. However, functional specificities yeast-derived immunoregulatory molecules remain elusive. Here we find that while under steady state, β-1,3-glucan-containing polysaccharides potentiate pro-inflammatory properties, a relatively less abundant class cell surface polysaccharides, dubbed mannan/β-1,6-glucan-containing (MGCP), capable...
The ribosomal protein genes of Saccharomyces cerevisiae, responsible for nearly 40% the polymerase II transcription initiation events, are characterized by constitutive tight binding factor Rap1. Rap1 binds at many places in yeast genome, including glycolytic enzyme genes, silent MAT loci, and telomeres, its specificity arising from specific cofactors recruited appropriate genes.At two such have recently been identified as Fhl1 Ifh1.We now interaction these factors a bidirectional promoter...
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Breast cancer is highly aggressive and the leading cause of cancer-related mortality in women developed countries. The ETS proto-oncogene 1 (Ets1) has versatile roles during cellular processes development. It often expressed breast cancers mediates migration invasion human cells. However, underlying mechanisms Ets1 gene expression still ambiguous. Here, we identified a core-regulatory element (CRE) located promoter region (-540/-80 bp from TSS) that contains elements responsible for...
Increasing plasma levels and activity of dipeptidyl peptidase-4 (DPP4 or CD26) are associated with rapid progression metabolic syndrome to overt type 2 diabetes mellitus (T2DM). While DPP4 inhibitors increasingly used as anti-hyperglycemic agents, the reason for increase in T2DM patients remains elusive. We looked into source a cohort 135 treatment naive nonobese (BMI < 30) patients. A wide array ex vivo, vitro, silico methods were employed study enzyme activity, gene expression, subcellular...
Abstract Regulatory T (Treg) cells, which are broadly classified as thymically derived (tTreg) or extrathymically induced (iTreg), suppress immune responses and display stringent dependence to the transcription factor Foxp3. However precise understanding of molecular events that promote preserve Foxp3 expression in Treg cells is still evolving. Here we show Foxp1, a forkhead sibling family member Foxp3, essential for sustaining optimal specifically iTreg cells. Deletion Foxp1 renders...
The concentration of cholesterol, apolipoproteins A-I, B, and E has been determined in lymphedema fluid from nine patients with chronic primary lymphedema.The concentrations were: 38.14 * 21.06 mg/dl for 15.6 f 6.17 apolipoprotein 7.5 2.8 1.87 0.50 E. These values represent 23%, 1276, 676, 38% plasma concentrations, respectively.The ratio esterified to unesterified cholesterol was 1.46 0.45.Lipoproteins were fractionated according particle size by gradient gel electrophoresis exclusion...
Several gut commensals have been shown to modulate host immune response.Recently, many food derived microbes also reported affect the system.However, a mechanism identify immunostimulatory and immunoregulatory is needed.Here, we successfully established an in vitro screening system identified bacterium, Lactobacillus pentosus KF340 (LP340), present various fermented foods.LP340 induced regulatory phenotype mice Ag presenting cells which, turn, IL-10 IFN-γ producing Type 1 T (Tr1 cells) from...
Foxp3 and its protein partners establish a regulatory T (Treg) cell transcription profile promote immunological tolerance. However, molecular features contributing to Treg-specific gene expression program are still incompletely understood. We find that the factor Bcl11b is prominent cofactor with multifaceted functions in Treg biology. Optimal genomic recruitment of critically interdependent. Genome-wide occupancy studies coupled profiling reveal Bcl11b, association Foxp3, primarily...
ETS1 has shown dichotomous roles as oncogene and tumor suppressor gene in diverse cancers, but its functionality breast cancer tumorigenesis still remains unclear. We utilized the Cancer Genome Atlas (TCGA) database to analyze comprehensive functions of human (BRCA) patients by investigating expression patterns methylation status relation clinical prognosis. was significantly diminished hyper-methylation on promoter region specimens from BRCA compared healthy control. Moreover, ETS1high...