A5054691687- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Laser-Plasma Interactions and Diagnostics
- Microbial Natural Products and Biosynthesis
- Crystallography and molecular interactions
- Marine Sponges and Natural Products
- Nuclear Physics and Applications
- Insect Pest Control Strategies
- Nuclear physics research studies
- Plant biochemistry and biosynthesis
- Phytochemistry and Bioactive Compounds
- Fungal Biology and Applications
- Phytochemistry and Bioactivity Studies
- Bioactive Natural Diterpenoids Research
- Genetic and phenotypic traits in livestock
- Laser-Matter Interactions and Applications
- Traditional and Medicinal Uses of Annonaceae
- Phytochemicals and Antioxidant Activities
- Synthetic Organic Chemistry Methods
- Supramolecular Chemistry and Complexes
- X-ray Spectroscopy and Fluorescence Analysis
- Cholesterol and Lipid Metabolism
- Laser-induced spectroscopy and plasma
Seikagaku Corporation (Japan)
2001-2025
Rigaku (Japan)
2000-2025
Toho University
2021-2025
Chiba Prefectural Institute of Public Health
2014-2025
Osaka University of Pharmaceutical Sciences
2014-2024
Kindai University
2013-2024
Chiba University
2024
Foundation for Biomedical Research and Innovation
2019-2023
High Energy Accelerator Research Organization
1991-2022
Japan Agency for Marine-Earth Science and Technology
2022
The objective of this study was to investigate changes in physical activity (PA) between January (before the COVID-19 epidemic) and April (during 2020 community-dwelling older adults Japan. Cross-sectional online survey. From 23 27, 2020, an survey completed by 1,600 We assessed frailty status using Kihon checklist, other demographics asked questions regarding PA at two time points: 2020. defined total (minutes) per week based on frequency time. participants' mean age, proportion women,...
The objective of this study was to investigate changes in physical activity (PA) between January (before the COVID-19 epidemic) and April (during 2020 community-dwelling older adults Japan.Cross-sectional online survey.From 23 27, 2020, an survey completed by 1,600 Japan.We assessed frailty status using Kihon checklist, other demographics asked questions regarding PA at two time points: 2020. We defined total (minutes) per week based on frequency time.The participants' mean age, proportion...
Silver nanoclusters have attracted scientific interest due to their properties and applications. However, practical synthetic methods access these materials are still limited mainly the low stability. Here, we report a controlled assembly strategy for fabricating atomically precise silver using polyoxometalates (POMs) as structure-directing well functionalizing units. A trefoil-propeller-shaped {Ag27}17+ nanocluster was synthesized by assembling reactive supported open-Dawson-type POMs...
We show here that La@C72 has a non-IPR cage, unique electronic properties, and high reactivity by the spectroscopic X-ray crystallographic analysis theoretical study. The isolation of as stable derivative might constitute an important stepping-stone on way to these unknown metallofullerenes open new material science metallofullerenes.
In one fell swoop, polyrotaxanes comprising up to 64 rings can be synthesized as a result of cucurbit[6]uril-templated 1,3-dipolar azide-alkyne cycloadditions accelerated in the presence cyclodextrins consequence self-sorting and positive cooperativity, brought about by hydrogen bonding. Mixing six components (see picture) pot affords hetero[4]rotaxane minute quantitative yield.
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized dominant phases variants concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha), 5 (Delta), 6 (Omicron BA.1/BA.2), 7 BA.5). Excess COVID-19-affected was analyzed by calculating standardized...
To investigate the cause of disagreement within large body literature concerning effect exercise on capacity circulating neutrophils to produce reactive oxygen species (ROS), 10 male endurance-trained athletes underwent maximal exercise. The generation superoxide radical (O2-.) by was first detected a cell-by-cell basis using histochemical nitro blue tetrazolium tests performed directly fresh unseparated blood, which showed that responsive under several stimulatory conditions relatively...
The first isolation of missing metallofullerene, La@C74, as a derivative is reported. structural determination has been performed by spectroscopic and, finally, X-ray crystallographic analysis, and the properties La@C74 are discussed on basis theoretical study.
Four triterpene acetates, α-amyrin acetate (1a), β-amyrin (2a), lupeol (3a), and butyrospermol (4a), four cinnamates, cinnamate (1c), (2c), (3c), (4c), were isolated from the kernel fat (n-hexane extract) of shea tree (Vitellaria paradoxa; Sapotaceae). Upon evaluation these eight esters for inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice, all compounds tested exhibited marked anti-inflammatory activity, with ID50 values range...
Thirty-five limonoids, including 15 of the azadiradione type (1-15), five gedunin (16-20), four azadirachtin (21-24), nine nimbin (25-33), and two degraded limonoids (34, 35), isolated from Azadirachta indica seed extracts, were evaluated for their cytotoxic activities against human cancer cell lines. Seven compounds (3, 6, 7, 16, 18, 28, 29) exhibited activity one or more Among these compounds, 7-deacetyl-7-benzoylepoxyazadiradione (7), 7-deacetyl-7-benzoylgeduin (18), 28-deoxonimbolide...
Albanol A (1), isolated from the root bark extract of Morus alba (mulberry), was evaluated for cytotoxic and apoptosis-inducing activities in human leukemia (HL60) cells, inhibitory activity DNA topoisomerases (Topo) I II. This compound showed potent (IC50 1.7 μM) on topoisomerase II 22.8 μM). In addition, albanol induced early apoptosis which detected by observing membrane phospholipid exposure flow cytometry. Western blot analysis that markedly reduced levels procaspases-3, 8, 9, while...
Six lanostane-type triterpene acids (1a−6a), isolated from Poria cocos, and their methyl ester (1b−6b) hydroxy derivatives (1c−6c) were prepared. Upon evaluation of the cytotoxic activity these compounds against leukemia (HL60), lung (A549), melanoma (CRL1579), ovary (NIH:OVCAR-3), breast (SK-BR-3), prostate (DU145), stomach (AZ521), pancreas (PANC-1) cancer cell lines, 11 (5a, 6a, 2b−5b, 1c, 3c−6c) exhibited with single-digit micromolar IC50 values one or more lines. Poricotriol A (1c), a...
The self-assembly of nanostructures is dominated by a limited number strong coordination elements. Herein, we show that metal-acetylene π-coordination tripodal ligand (L) with acetylene spacers gave an M3 L2 double-propeller motif (M=CuI or AgI ), which dimerized into M6 L4 interlocked cage ). Higher (M3 )n oligomers were also selectively obtained: M12 L8 truncated tetrahedron ) and M18 L12 trigonal prism (M=AgI both contain the same motif. higher exhibit multiply entangled facial structures...
Perfectly monodisperse DNA nanoparticles were prepared via the self-assembly of 12 Pd(II) ions and 24 bidentate ligands functionalized with oligonucleotides varying length (n = 1−3). The formed hydrogen bonds cDNA strands an insoluble aggregate only matching trimeric nucleotide (tri-A).