A5031651165- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Renal Transplantation Outcomes and Treatments
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Renal cell carcinoma treatment
- Liver physiology and pathology
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
- Viral-associated cancers and disorders
- Complement system in diseases
The University of Tokyo
2016-2025
University of Tokyo Hospital
2019-2024
National Center For Child Health and Development
2022
Saitama Medical University
2008-2021
Social Insurance Saitama Chuo Hospital
2008-2021
Bunkyo University
2018-2019
University of Oslo
2018
Kyushu University
2018
Kyoto University
2018
New Generation University College
2018
Indocyanine green (ICG) is a photothermal agent, photosensitizer, and fluorescence imaging probe which shows specific accumulation in hepatocellular carcinoma (HCC) cells. We recently developed photodynamic therapy (PDT) using ICG near-infrared (NIR) laser as new anti-cancer treatment for HCC. However, the molecular mechanism underlying this effect needs to be elucidated. HuH-7 cells, well-differentiated human HCC cell line, were transplanted subcutaneously into BALB/c-nu/nu mice vivo...
Objective: To assess how virtual hepatectomy (VH), conducted using surgical planning software, influences the outcomes of liver surgery. Background: Imaging technology visualizes territories vessels, which were previously impossible. However, clinical impact VH has not been evaluated. Methods: From 2004 to 2013, we performed 1194 VHs preoperatively. Outcomes living donor transplantation (LDLT) and for hepatocellular carcinoma (HCC)/colorectal metastases (CRLM) compared between patients in...
Early allograft dysfunction (EAD) affects outcomes in liver transplantation (LT). Existing risk models developed for deceased-donor LT depend on posttransplant factors and fall short living-donor (LDLT), where pretransplant evaluations are crucial preventing EAD justifying the donor's risks. This retrospective study analyzed data from 2944 adult patients who underwent LDLT at 17 centers between 2016 2020. We a logistic regression model to predict based this development cohort. used 1020 King...
Short and direct vein anastomosis is generally performed in living donor liver transplantation using a right graft. The graft will regenerate, however, might thus compress the anastomosis. We formulated strategy for outflow reconstruction When of multiple short hepatic veins was necessary, cryopreserved inferior vena cava anastomosed with basin. there were no major graft, rectangular-shaped used to make single orifice middle tributaries be reconstructed, diamond-shaped patch on anterior wall...
Abstract Objective Postoperative pancreatic fistula (POPF) is a severe and frequent complication after pancreaticoduodenectomy (PD). The aim of this study was to identify an independent predictor POPF assess the efficacy preoperative multidetector row computed tomography (MDCT) images as indicator for POPF. Methods A total 122 patients who underwent PD with end‐to‐side, duct‐to‐mucosa pancreaticojejunostomy between January 2005 May 2009 were retrospectively reviewed. diameter main duct...
Background Most patients with hepatocellular carcinoma (HCC) have underlying liver disease, therefore, precise preoperative evaluation of the patient's function is essential for surgical decision making. Methods We developed a grading system incorporating only two variables, namely, serum albumin level and indocyanine green retention rate at 15 minutes (ICG R15), to assess function, based on overall survival 1868 HCC who underwent resection. then tested model in European cohort (n = 70)...
BACKGROUND The high prevalence of specific immunoglobulin G for hepatitis E virus (HEV) in Japanese people raises the possibility a incidence HEV‐viremic blood donors and therefore frequent transfusion‐transmitted HEV (TT‐HEV). STUDY DESIGN AND METHODS TT‐HEV cases established Japan through hemovigilance those published literature were collected. Infectivity HEV‐contaminated components disease severity relation to immunosuppression investigated. RESULTS Twenty recorded over past 17 years. A...
The excess mortality of coronavirus disease 2019 (COVID-19) solid organ transplant recipients (SOTRs) throughout the pandemic remains unclear. This prospective cohort study based on Japanese nationwide registry included 1632 SOTRs diagnosed with COVID-19 between February 1, 2020, and July 31, 2022, categorized dominant phases variants concern (VOCs): Waves 1 to 3 (Beta), 4 (Alpha), 5 (Delta), 6 (Omicron BA.1/BA.2), 7 BA.5). Excess COVID-19-affected was analyzed by calculating standardized...
Background. Living-donor liver transplantation (LDLT) is important for patients with end-stage viral hepatitis because of the cadaveric organ shortage. Preliminary results, however, indicate that LDLT might be disadvantageous positive C virus (HCV). Methods. The subjects were 23 who underwent HCV cirrhosis. All preemptively received antiviral therapy consisting interferon-alfa2b and ribavirin, which was started approximately 1 month after operation. continued 12 months first negative RNA...
Background. Bile duct-to-duct reconstruction is now used in living-donor liver transplantation (LDLT) for adult patients. Methods. The results of were retrospectively analyzed. subjects 81 patients who underwent LDLT at the University Tokyo Hospital with a follow-up period least 1 year. hilar plate recipient was dissected to second-order branch bile ducts. Duct-to-duct anastomosis performed interrupted sutures, and an external stent tube inserted from orifice opposite plate. Results. During...
The aim of this review is to describe recent advances and topics in the surgical management bile duct cancer. Radical resection with a microscopically negative margin (R0) only way cure cholangiocarcinoma associated marked survival advantages compared margin-positive resections. Complete tumor surgeon's ultimate aim, several treatment for cancer have been made within last two decades. Multidetector row computed tomography has emerged as an indispensable diagnostic modality precise...
Simultaneous splenectomy (SPX) is preferentially performed in living donor liver transplantation (LDLT) to modulate portal flow; increase postoperative platelet count, especially among those with hepatitis C virus (HCV) infection; and the immunologic status ABO‐incompatible cases. The negative effects of procedure, however, are not well established. Records 395 LDLTs at our institution, including 169 (42.8%) patients simultaneous SPX 226 (57.2%) spleen preservation, were reviewed special...
Abstract Background Primary sclerosing cholangitis (PSC) is relatively rare disease and pathogenesis methods of treatments were still not established. Then, we had conducted the making clinical guidelines to manage patients with PSC based on literature review expert opinions. These made for medical doctors management PSC, except child case PSC. Methods We employed modified Delphi method. The production committee decided guidelines, strength recommendations evidence level after reviewed...