A5001521096- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Congenital Anomalies and Fetal Surgery
- Liver physiology and pathology
- Transplantation: Methods and Outcomes
- Hepatitis B Virus Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Advanced Glycation End Products research
- Gallbladder and Bile Duct Disorders
- Cancer, Lipids, and Metabolism
- Viral-associated cancers and disorders
- Clinical Nutrition and Gastroenterology
- Polyomavirus and related diseases
- Palliative Care and End-of-Life Issues
- Liver Diseases and Immunity
- Hematopoietic Stem Cell Transplantation
- Genetic and Kidney Cyst Diseases
- COVID-19 Clinical Research Studies
- Drug-Induced Hepatotoxicity and Protection
Columbia University Irving Medical Center
2016-2025
New York Hospital Queens
2008-2024
NewYork–Presbyterian Hospital
2012-2024
Columbia University
2014-2023
Instituto Murciano de Investigación Biosanitaria
2023
Mayo Clinic in Florida
2023
Beijing Tsinghua Chang Gung Hospital
2023
National University Health System
2023
Cornell University
2013-2023
University Hospital of Zurich
2004-2023
Translational studies in liver transplantation often require an endpoint of graft function or dysfunction beyond loss. Prior definitions early allograft (EAD) vary, and none have been validated a large multicenter population the Model for End-Stage Liver Disease (MELD) era. We examined updated definition EAD to validate previously used criteria, correlated this with patient outcome. performed cohort study 300 deceased donor transplants at 3 U.S. programs. was defined as presence one more...
Solid organ transplant recipients may be at a high risk for SARS-CoV-2 infection and poor associated outcomes. We herein report our initial experience with solid two centers during the first 3 weeks of outbreak in New York City. Baseline characteristics, clinical presentation, antiviral immunosuppressive management were compared between patients mild/moderate severe disease (defined as ICU admission, intubation or death). Ninety analyzed median age 57 years. Forty-six kidney recipients, 17...
The University of Chicago program in pediatric liver transplantation continues actively to seek innovative surgical solutions problems related the management children with end-stage disease. Among most important facing these is a shortage donor organs, which results from three factors addition actual supply donors: concentration disease population younger than 2 years; necessity for graft that small enough; and epidemiology accidents other events lead organ donation. Transplantation using...
It is critical to balance waitlist mortality against posttransplant mortality. Our objective was devise a scoring system that predicts recipient survival at 3 months following liver transplantation complement MELD-predicted Univariate and multivariate analysis on 21,673 transplant recipients identified independent donor risk factors for A retrospective conducted 30,321 waitlisted candidates reevaluated the predictive ability of Model End-Stage Liver Disease (MELD) score. We 13 factors, 4 2...
The Milan criteria have been adopted by United Network for Organ Sharing (UNOS) to preoperatively assess outcome in patients with hepatocellular carcinoma (HCC) who receive orthotopic liver transplantation (OLT). These rely solely on radiographic appearances of the tumor, providing no measure tumor biology. Recurrence rates, therefore, remain around 20% within criteria. neutrophil-lymphocyte ratio (NLR) is an indicator inflammatory status previously established as a prognostic colorectal...
The objective of this study was to characterize the patient population with respect selection, assess surgical morbidity and graft failures, analyze contribution perioperative clinical factors recipient outcome in adult living donor liver transplantation (ALDLT).Previous reports have been center-specific or from large databases lacking detailed variables. Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL) represents first North American multicenter report risk aiming...
Liver transplantation involving only a portion of liver from cadaveric donor is now performed in several major centers worldwide. We propose to transplant lobe living — the parent recipient noncritically ill infant with advanced disease. Although it technically feasible, such an organ raises complex ethical issues balance risks and benefits, selection recipient, informed consent. This article describes unique aspects parents as donors our .
Hypothermic machine preservation (HMP) remains investigational in clinical liver transplantation. It is widely used to preserve kidneys for transplantation with improved results over static cold storage (SCS). At our center, we have HMP 31 adults receiving extended criteria donor (ECD) livers declined by the originating United Network Organ Sharing region ("orphan livers"). These cases were compared ECD SCS a matched cohort study design. Livers age, recipient ischemic time, risk index and...
We sought to develop a "Model Of Recurrence After Liver transplant" (MORAL) for hepatocellular carcinoma (HCC).The Milan criteria are used allocate livers patients with HCC requiring liver transplantation (LT) but do not include objective measures of tumor biology. Biological markers including the neutrophil-lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) have been associated recurrence risk.Prospective cohort study adults undergoing LT between January 2001 December 2012.A total 339 were...
<h3>Importance</h3> National guidelines on transplant selection have adopted successful downstaging to within Milan criteria (MC) as a viable option for the treatment of hepatocellular carcinoma (HCC) before liver (LT). Recurrence HCC after LT carries poor prognosis, and modalities remain challenging. <h3>Objective</h3> To establish 10-year outcomes patients with in large, multicenter US study based individual data; provide robust data long-term role downstaging; evaluate association...
Living-related liver transplantation (LRLT) has established efficacy in children. In a larger recipient, LRLT requires the use of small graft because limits on donor hepatectomy.The minimum weight required for successful not been well established, although characteristic pattern dysfunction observed our patients who receive grafts. The authors present clinicopathologic study grafts obtained from living donors.Clinical and histologic data were reviewed 25 receiving LRLT. five older recipients...
A consensus meeting to develop guidelines that would improve the recovery and transplantation of organs from cadaver donor was held on 28–29 March 2001, in Crystal City, Virginia, sponsored by American Society Transplant Surgeons Transplantation. The crisis organ supply persists continuing shortage presents a compelling responsibility for transplant community maximize use procured donors.
Wachs, Michael E.; Amend, William J.; Ascher, Nancy L.; Bretan, Peter N.; Emond, Jean; Lake, John R.; Melzer, Juliet S.; Roberts, P.; Tomlanovich, Steve Vincenti, Flavio; Stock, Author Information
Wachs, Michael E.; Amend, William J.; Ascher, Nancy L.; Bretan, Peter N.; Emond, Jean; Lake, John R.; Melzer, Juliet S.; Roberts, P.; Tomlanovich, Steve Vincenti, Flavio; Stock, Author Information
Surgical reduction of donor livers to treat small children has been performed successfully in several centers. While this procedure improves the allocation livers, it does not increase organ supply. We have extended reduced-size orthotopic liver transplantation (OLT) 18 patients with 9 accounting for 26% our transplants during a 10-month period and evaluated results. In split OLTs, patient survival was 67% graft 50%. comparison, 34 treated full-size OLT same period, 84% (p = 0.298) 76%...
In explant livers with chronic hepatitis C (HCV-C) we have noted a distinctive histologic variant that termed steatohepatitic hepatocellular carcinoma (SH-HCC) features resembling non-neoplastic steatohepatitis, including large droplet steatosis, ballooning of malignant hepatocytes, Mallory-Denk bodies, inflammation, and pericellular fibrosis. This study was undertaken to further describe the characteristics prevalence this in HCV-C any possible association underlying risk factors for...
Orthotopic liver transplantation (OLT) of the pediatric patient is often limited by availability a size-matched donor organ. Use reduced (RLT) can increase proportion candidates transplanted and may reduce overall mortality. We report herein initial clinical application RLT in United States. Indications for included fulminant hepatic failure (n = 2), acute artery thrombosis 3), chronic disease unresponsive to inpatient support more than 30 days on transplant list 4). Donor hepatectomy was...
The objective of this study was to evaluate the effect systematic utilization extended donor criteria liver allografts (EDC), including living (LDLT), on patient access transplantation (LTX).Utilization that do not meet traditional (EDC) offer immediate expansion pool. EDC are typically allocated by transplant center rather than regional wait-list priority (RA). This single-institution series compares outcomes and RA allocation determine impact use LTX.The authors conducted a retrospective...
The clinical course of 37 patients who underwent 46 liver transplantations for primary (n = 33) and secondary 4) sclerosing cholangitis was reviewed. median follow-up months. patient graft survivals with at 1, 2, 5 years were 96.9%, 91.6%, 87.9%, 83.1%, 74.2%, 65.2%, respectively. In the (PSC), prior surgery except simple cholecystectomy associated significantly greater operative time blood loss. No cholangiocarcinoma identified transplantation. Human leukocyte antigen typing PSC heavily...
Hepatic ischemia/reperfusion (I/R) injury associated with liver transplantation and hepatic resection is characterized by hepatocellular damage a deleterious inflammatory response. In this study, we examined whether receptor for advanced glycation end product (RAGE) activation linked to mechanisms accentuating inflammation on I/R in murine model of total ischemia. Animals treated soluble RAGE (sRAGE), the extracellular ligand-binding domain RAGE, displayed increased survival after compared...
In Brief Objective: Preventing retained foreign bodies is critical for patient safety. However, the value of counting surgical instruments and reliability information provided have never been quantified. This study examines diagnostic characteristics its impact on costs. Methods: We examined data from Medical Event Reporting System-Total HealthSystem (MERS-TH), administrative hospital, New York State Cardiac Surgery Report databases (2000–2004). The cost per count discrepancy was by studying...