A5056437755- Organ Transplantation Techniques and Outcomes
- Xenotransplantation and immune response
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Animal Genetics and Reproduction
- Organ Donation and Transplantation
- Immune Cell Function and Interaction
- Tissue Engineering and Regenerative Medicine
- Virus-based gene therapy research
- Transplantation: Methods and Outcomes
- Immunotherapy and Immune Responses
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver physiology and pathology
- Congenital Anomalies and Fetal Surgery
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Clinical Nutrition and Gastroenterology
- Anesthesia and Neurotoxicity Research
- Viral-associated cancers and disorders
- Organ and Tissue Transplantation Research
- CAR-T cell therapy research
New York University
2023-2025
Miami Transplant Institute
2022-2025
NYU Langone Health
2023-2025
Columbia University
2015-2024
Columbia University Irving Medical Center
2014-2023
Washington University in St. Louis
2000-2023
Yale University
2023
University of Minnesota
2023
Winterthur Museum Garden and Library
2023
Angion (United States)
2023
Xenografts from genetically modified pigs have become one of the most promising solutions to dearth human organs available for transplantation. The challenge in this model has been hyperacute rejection. To avoid this, bred with a knockout alpha-1,3-galactosyltransferase gene and subcapsular autologous thymic tissue.We transplanted kidneys these into two brain-dead recipients whose circulatory respiratory activity was maintained on ventilators duration study. We performed serial biopsies...
We sought to develop a "Model Of Recurrence After Liver transplant" (MORAL) for hepatocellular carcinoma (HCC).The Milan criteria are used allocate livers patients with HCC requiring liver transplantation (LT) but do not include objective measures of tumor biology. Biological markers including the neutrophil-lymphocyte ratio (NLR) and alpha-fetoprotein (AFP) have been associated recurrence risk.Prospective cohort study adults undergoing LT between January 2001 December 2012.A total 339 were...
Priority is given to patients with hepatocellular carcinoma (HCC) receive liver transplants, potentially causing significant regional disparities in organ access and possibly outcomes this population. Our aim was assess these by comparing long waiting time regions (LWTR, 5 9) short (SWTR 3 10) analyzing the United Network for Organ Sharing (UNOS) database. We analyzed 6,160 HCC who received exception points 3, 5, 9, 10 from 2002 2012. Data 9 were combined compared data 10. Survival studied...
A paradigm in transplantation states that graft-infiltrating T cells are largely non-alloreactive "bystander" cells. However, the origin and specificity of allograft over time has not been investigated detail animals or humans. Here, we use polychromatic flow cytometry high throughput TCR sequencing serial biopsies to show gut-resident cell turnover kinetics human intestinal allografts correlated with balance between intra-graft host-vs-graft (HvG) graft-vs-host (GvH) reactivities clinical...
The aim of the study was to compare short-term donor outcomes laparoscopic left lateral sectionectomy (LLLS) for adult child living liver transplantation (A-C LDLT) and nephrectomy (LDN).Although laparoscopy has become standard approach in kidney donors, its use remains limited controversial LLS A-C LDLT due lack conclusive assessment procedure-related morbidity.From 2001 2014, 124 healthy donors undergoing LLLS at 5 tertiary referral centers Europe, North America, Asia, 300 LDN 2 Europe...
We present a case of COVID-19 hepatitis in living donor liver allograft recipient whose subsequently tested positive for COVID-19. The patient is female infant with biliary atresia (failed Kasai procedure). She recovered well, improving function tests 4 days. On postoperative day the developed respiratory distress and fever. testing (polymerase chain reaction) was positive. Liver test results increased approximately 5-fold. biopsy showed moderate acute prominent clusters apoptotic...
Background and Aims: In liver transplantation, cold preservation induces ischemia, resulting in significant reperfusion injury. Hypothermic oxygenated machine perfusion (HMP-O 2 ) has shown benefits compared to static storage (SCS) by limiting ischemia-reperfusion This study reports outcomes using a novel portable HMP-O device the first US randomized control trial. Approach Results: The PILOT trial (NCT03484455) was multicenter, randomized, open-label, noninferiority trial, with participants...
Xenotransplantation of genetically engineered porcine organs has the potential to address challenge organ donor shortage. Two cases porcine-to-human kidney xenotransplantation were performed, yet physiological effects on xenografts and recipients' immune responses remain largely uncharacterized.
Living donor liver transplantation has failed to become a major means of in the United States, where <5% transplants are performed with living donors. At least 30% 50% complications hepatectomy appear be related abdominal wall trauma, including hernia, bowel obstruction, and chronic discomfort. We analyzed our experience laparoscopically procured hepatectomy. compared 22 full laparoscopic hepatectomies 20 open/hybrid over an 11-year period. Donor recipient demographics, complications, graft...
Organ donors are sources of physiologically healthy organs and tissues for life-saving transplantation, have been recently used human immunology studies which typically confined to the sampling peripheral blood. Donors comprise a diverse population with different causes death clinical outcomes during hospitalization, effects such variations on immune parameters in blood not known. We present here coordinate analysis innate adaptive components blood, lymphoid (bone marrow, spleen, lymph...
Infusion of recipient regulatory T (Treg) cells promotes durable mixed hematopoietic chimerism and allograft tolerance in mice receiving allogeneic bone marrow transplant (BMT) with minimal conditioning. We applied this strategy a Cynomolgus macaque model.CD4 CD25 Treg that were polyclonally expanded culture highly suppressive vitro maintained high expression FoxP3. Eight monkeys underwent nonmyeloablative conditioning major histocompatibility complex mismatched BMT or without cell infusion....
In humans receiving intestinal transplantation (ITx), long-term multilineage blood chimerism often develops. Donor T cell macrochimerism (≥4%) frequently occurs without graft-versus-host disease (GVHD) and is associated with reduced rejection. Here we demonstrate that patients had high (GvH) to host-versus-graft (HvG) clonal ratios in their allografts. These GvH clones entered the circulation, where peak levels were declines HvG early after transplant, suggesting reactions may contribute...