A5011887503- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Pulmonary Hypertension Research and Treatments
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Airway Management and Intubation Techniques
- Fuel Cells and Related Materials
- Tissue Engineering and Regenerative Medicine
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Tracheal and airway disorders
- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Neonatal Respiratory Health Research
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Healthcare Policy and Management
- Extracellular vesicles in disease
- Xenotransplantation and immune response
- Intensive Care Unit Cognitive Disorders
- Cystic Fibrosis Research Advances
State University of New York
2023
SUNY Downstate Health Sciences University
2023
Vanderbilt University Medical Center
2018-2022
Columbia University Irving Medical Center
2018-2020
Vanderbilt University
2019
Columbia University
2018
Abstract Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types. The role of endothelial cells (EC) in is poorly understood. Using single RNA-sequencing we identified transcription factors involved fibrogenesis, including FOXF1, SMAD6, ETV6 LEF1. Focusing on found that FOXF1 decreased EC within human idiopathic pulmonary (IPF) mouse bleomycin-injured lungs. Endothelial-specific Foxf1 inhibition mice increased collagen depositions, promoted inflammation,...
ObjectivesLung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited <24 hours of support. Here, we demonstrate feasibility extending normothermic extracorporeal lung support 4 days cross-circulation conscious swine.MethodsA swine behavioral training program and custom enclosure were developed enable multiday between recipient swine. Lungs ventilated perfused in a chamber days....
Patients receiving extracorporeal membrane oxygenation (ECMO) often require prolonged mechanical ventilation. Providers may be reluctant to perform tracheostomies on patients during ECMO due their tenuous clinical status and systemic anticoagulation. We report our experience with performing open percutaneous supported from August 2009 December 2017. Of the 127 who underwent tracheostomy support, median age was 42 years (interquartile range [IQR], 29–54), 99 (78%) had venovenous (VV)...
Rationale: Early mobilization of extracorporeal membrane oxygenation (ECMO)-supported patients is increasingly common, but it remains unknown whether there are factors predictive achieving higher intensity among those able to participate in physical therapy. Additionally, data regarding the safety and feasibility early with femoral cannulation, particularly ambulation, sparse. Objectives: To determine associated out-of-bed versus in-bed therapy ECMO-supported participating therapy,...
Objectives: Venovenous extracorporeal carbon dioxide removal may be lifesaving in the setting of status asthmaticus. Design: Retrospective review. Setting: Medical ICU. Patients: Twenty-six adult patients with asthmaticus treated venovenous removal. Interventions: None. Measurements and Main Results: Demographic data characteristics current prior asthma treatments were obtained from electronic medical record. Mechanical ventilator settings, arterial blood gases, vital signs, use vasopressors...
Pulmonary hypertension (PH) is a progressive disease that leads to cardiopulmonary dysfunction and right heart failure from pressure volume overloading of the ventricle (RV). Mechanical support has theoretical promise as bridge organ transplant or destination therapy for these patients. Solving challenges mechanical PH RV requires its testing in physiologically relevant animal model. Previous models large animals have used pulmonary bead embolization, which elicits unpredictable inflammatory...
Background: Despite the rapid integration of extracorporeal membrane oxygenation (ECMO) into intensive care units over past decade, established programs for training critical clinicians to provide ECMO are lacking.Objective: To evaluate development and implementation a multidisciplinary program deployment high volume clinicians.Methods: We performed prospective cohort study examining multiple disciplines deliver during services across an academic tertiary center between October 2018 January...
Background Despite the growing use of extracorporeal membrane oxygenation (ECMO) in intensive care units (ICUs), no standardized ECMO training pathways are available for ECMO-naive critical nurses. Objectives To evaluate a nurse curriculum that may be reproducible across institutions. Methods An consisting basic safety course and an advanced user was designed Courses incorporated didactic simulation components, written knowledge examinations, electronic modules. Differences examination...
Extracorporeal life support (ECLS) is a resource-intensive technology. Disposable components are modifiable through device selection. Cost analysis tools needed to inform cost-conscious We generated disposable cost forecast estimated costs of disposables that included an assumption table, net present value (NPV) analysis, and sensitivity examine over 5 years with different case volumes mixes. To demonstrate the function we four options using following assumptions: 100 cases in year 1, 2.5%...