A5069429469- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Tissue Engineering and Regenerative Medicine
- Rings, Modules, and Algebras
- Electrospun Nanofibers in Biomedical Applications
- Organ Transplantation Techniques and Outcomes
- Transplantation: Methods and Outcomes
- Commutative Algebra and Its Applications
- Osteoarthritis Treatment and Mechanisms
- Renal and Vascular Pathologies
- Mechanical Circulatory Support Devices
- Orthopedic Surgery and Rehabilitation
- Tracheal and airway disorders
- Tendon Structure and Treatment
- Advanced Topology and Set Theory
- Advanced Topics in Algebra
- Organ Donation and Transplantation
- Shoulder Injury and Treatment
- Renal Transplantation Outcomes and Treatments
- Orthopedic Infections and Treatments
- Neonatal Respiratory Health Research
- Algebraic structures and combinatorial models
- Musculoskeletal synovial abnormalities and treatments
- Inhalation and Respiratory Drug Delivery
SUNY Downstate Health Sciences University
2020-2025
State University of New York
2020-2025
Columbia University
1941-2025
Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal
2025
Centre intégré universitaire de santé et de services sociaux du Nord-de-l’Île-de-Montréal
2025
Concordia University
1984-2025
Vanderbilt University
2021
E Ink (South Korea)
2021
Stanford University
2021
St. Joseph’s Healthcare Hamilton
2005-2019
We propose a new approach to lung regeneration by replacement of damaged epithelium with full preservation vasculature.
<b>Objective</b> To assess whether equity exists in access to renal transplantation the UK after adjustment for case mix incident patients with end stage disease. <b>Design</b> Longitudinal cohort study. <b>Setting</b> Renal Registry and Transplant Registry. <b>Participants</b> All replacement treatment (n=16 202) from 65 centres submitting data between 1 January 2003 31 December 2005, followed until 2008 (or or death, whichever was earliest). <b>Outcome measures</b> Proportion of dialysis...
The number of available donor organs limits lung transplantation, the only lifesaving therapy for increasing population patients with end-stage disease. A prevalent etiology injury that renders lungs unacceptable transplantation is gastric aspiration, a deleterious insult to pulmonary epithelium. Currently, severely damaged cannot be salvaged existing devices or methods. Here we report regeneration repaired meet criteria by utilizing an interventional cross-circulation platform in clinically...
ObjectivesLung remains the least-utilized solid organ for transplantation. Efforts to recover donor lungs with reversible injuries using ex vivo perfusion systems are limited <24 hours of support. Here, we demonstrate feasibility extending normothermic extracorporeal lung support 4 days cross-circulation conscious swine.MethodsA swine behavioral training program and custom enclosure were developed enable multiday between recipient swine. Lungs ventilated perfused in a chamber days....
Access to life-saving lung transplantation remains limited by a shortage of donor organs. We have previously described rehabilitation discarded human lungs quality suitable for using cross-circulation whole blood between xeno-support swine and lungs. However, the immunologic implications transplanting rehabilitated remain unknown. Human declined clinical (N=5) underwent xenogeneic up 12 hours. To model subsequent transplantation, were re-exposed autologous via normothermic ex vivo machine...
Outcomes after deceased heart beating donor kidney transplantation are good, but survival rates vary according to a number of donor-, recipient-, and transplant-related factors. This comprehensive analysis transplant outcomes was undertaken inform development new Kidney Allocation Scheme.A complete case the outcome kidney-only transplants in United Kingdom, 1995 2001, using Cox regression modeling. Seven thousand three hundred eighty-five (77%) 9585 reported UK Transplant Registry were...
The clinical use of minimum joint space width (mJSW) and cartilage volume thickness has been limited to the longitudinal measurement disease progression (i.e. change over time) rather than diagnosis OA in which values are compared a standard. This is primarily due lack establishment normative morphometry as done with bone density diagnosing osteoporosis. Thus, purpose this pilot study estimate reference medial healthy individuals all ages using standard radiography peripheral magnetic...
Intratracheal delivery of stem cells into injured or diseased lungs can provide a variety therapeutic and immunomodulatory effects for the treatment acute lung injury chronic disease. While efficacy this approach depends on delivering proper cell dosage target region airway, tracking analysis have been challenging, largely due to limited understanding transport lack suitable monitoring techniques. We report deposition intratracheally delivered as well strategies modulate number (e.g., dose),...
Significance Systemic drug administrations suffer from inefficient delivery to a specific pathologic region of the lung. Aerosolized drugs, when prepared display desired transport behavior, can be delivered selected lung regions by inhalation. We describe an alternative method for delivering drugs directly in form liquid microvolumes based on mathematical model. Deposition film epithelium different target was confirmed rat lungs using fluorescence imaging. propose that instilling would...
Journal Article EFFECTS OF DESOXYCORTICOSTERONE ACETATE IN THE ALBINO RAT Get access WILLIAM H. CARNES, CARNES 1From the Departments of Pathology, Medicine, and Neurology, College Physicians Surgeons, Columbia University NEW YORK CITY Search for other works by this author on: Oxford Academic Google Scholar CHARLES RAGAN, RAGAN JOSEPH W. FERREBEE, FERREBEE JOHN ONEILL Endocrinology, Volume 29, Issue 1, 1 July 1941, Pages 144–149, https://doi.org/10.1210/endo-29-1-144 Published: 01 1941...
Abstract Estrogen receptor–positive (ER+) metastatic tumors contribute to nearly 70% of breast cancer–related deaths. Most patients with ER+ cancer (MBC) undergo treatment the estrogen receptor antagonist fulvestrant as standard care. Yet, among such patients, metastasis in liver is associated reduced overall survival compared other sites. The factors underlying responsiveness metastases ER-targeting agents remain unknown, impeding development more effective approaches improve outcomes for...