A5030098968- Hematopoietic Stem Cell Transplantation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Influenza Virus Research Studies
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Respiratory viral infections research
- Xenotransplantation and immune response
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Mesenchymal stem cell research
- Organ Transplantation Techniques and Outcomes
- Phagocytosis and Immune Regulation
- Biosimilars and Bioanalytical Methods
- Pancreatic function and diabetes
- Animal Genetics and Reproduction
- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Diabetes and associated disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Neonatal Respiratory Health Research
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Myeloid Leukemia Research
- Immune cells in cancer
- Cancer Research and Treatments
Jilin University
2016-2025
Model Animal Research Center
2017-2025
Sun Yat-sen University
2023-2025
First Hospital of Jilin University
2015-2024
Amgen (United States)
2007-2024
Defense Health Agency
2024
Institute of Immunology
2018-2023
Columbia University
2011-2019
Jilin Medical University
2018
Jilin International Studies University
2017-2018
Abstract Lung injury and fibrosis represent the most significant outcomes of severe acute lung disorders, including COVID-19. However, there are still no effective drugs to treat fibrosis. In this study, we report generation clinical-grade human embryonic stem cells (hESCs)-derived immunity- matrix-regulatory (IMRCs) produced under good manufacturing practice requirements, that can in vivo. We generate IMRCs by sequentially differentiating hESCs with serum-free reagents. possess a unique...
In photoswitches that undergo fluorescence switching upon ultraviolet irradiation, photoluminescence and photoisomerization often occur simultaneously, leading to unstable properties. Here, we successfully demonstrated reversible solid-state triple through "Pump-Trigger" multiphoton manipulation. A novel photoswitch, BOSA-SP, achieved green, yellow, red under excitation by pump light isomerization induced trigger light. The energy ranges of photoexcitation did not overlap, enabling...
Significance Type 1 diabetes (T1D) is known to be caused by immune destruction of insulin-producing β cells, but the disease pathogenesis remains poorly understood largely because limitations in animal models study immunopathology. Here we established a humanized mouse T1D model, which driven human T cells recognizing HLA-DQ8–restricted insulin B chain peptide consisting amino acids 9–23 (InsB:9–23). This not only demonstrates capacity InsB:9–23-specific CD4 initiate also provides...
The efficient total synthesis of the natural substance largazole is described. Using this strategy, a small library analogs was developed. Structure−activity relationship studies suggested that geometry alkene in side chain critical. While largazole's analogues with trans-alkene are potent for antiproliferative effect, those cis-alkene completely inactive. Most importantly, replacement valine tyrosine increased selectivity toward human cancer cells over normal more than 100-fold.
// Zheng Hu 1,2 , Jinxing Xia 2 Wei Fan 1 Jennifer Wargo 3 and Yong-Guang Yang The First Bethune Hospital Institute of Immunology, Jilin University, Changchun, China Columbia Center for Translational Department Medicine, University College Physicians Surgeons, New York, NY, USA Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, Correspondence to: Yang, email: Keywords : animal model, immunotherapy, melanoma, TCR, T cells, Immunology Microbiology Section, Immune...
Background. Xenogeneic organ transplantation has been proposed as a potential approach to fundamentally solve shortage problem. immune responses across species is one of the major obstacles for clinic application xeno-organ transplantation. The generation glycoprotein galactosyltransferase α 1, 3 ( GGTA1 ) knockout pigs greatly contributed reduction hyperacute xenograft rejection. However, severe rejection can still be induced by xenoimmune porcine histocompatibility complex antigens swine...
Evolving immunogenicity assay performance expectations and a lack of harmonized neutralizing antibody validation testing reporting tools have resulted in significant time spent by health authorities sponsors on resolving filing queries. A team experts within the American Association Pharmaceutical Scientists' Therapeutic Product Immunogenicity Community across industry Food Drug Administration addressed challenges unique to cell-based non-cell-based assays. Harmonization data will facilitate...
Thrombospondin-1 (TSP-1)/CD47 signaling induces cell death and inhibits angiogenesis. Here, we investigated the possibility of improving donor engraftment by blocking TSP-1/CD47 pathway in mouse models total body irradiation (TBI)-conditioned syngeneic hematopoietic stem transplantation (HSCT). Our findings revealed that HSCT was improved mice deficient CD47 (Cd47 -/- ) or TSP-1 (Thbs1 compared to wild-type (WT) mice. The lack enhanced production CXCL12 megakaryocytes platelets, promoting...
Oral cancer vaccines are convenient and safe, with the presence of gut-associated lymphoid tissue (GALT) involved intestinal Peyer's patch (PPs) containing microfold (M) cells housing abundant underneath dendritic (DCs). Here, we found that endocytic receptors glycoprotein 2 (GP2) dectin-1 respectively expressed on M DCs high specificity. Then, discovered a gastrointestinal hydrolysis-resistant D-peptide DGPBP-2(1-8) targeting GP2 by phage display screening optimization. was conjugated to...
Drug misuse is associated with serious health consequences and has detrimental effects on military readiness. During 2000 to 2011, 70,104 service members received an incident diagnosis of a substance use disorder (SUD) (excluding alcohol tobacco-related disorders). Incidence rates declined increasing age, time in service, rank, number combat deployments. Service occupation had 1.2 times the rate individuals care or administation/supply occupation. The median discharge after SUD was longest...