A5100627065- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Supramolecular Self-Assembly in Materials
- Advanced Nanomaterials in Catalysis
- Enzyme Catalysis and Immobilization
- Gold and Silver Nanoparticles Synthesis and Applications
- biodegradable polymer synthesis and properties
- Chemical Synthesis and Analysis
- Nanocluster Synthesis and Applications
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Microplastics and Plastic Pollution
- Biosensors and Analytical Detection
- Catalytic C–H Functionalization Methods
- Luminescence and Fluorescent Materials
- Biofuel production and bioconversion
- Metal-Organic Frameworks: Synthesis and Applications
- Microbial Metabolites in Food Biotechnology
- Nanomaterials for catalytic reactions
- Plasmonic and Surface Plasmon Research
- Click Chemistry and Applications
- Photodynamic Therapy Research Studies
- Synthesis and Catalytic Reactions
- Enzyme Production and Characterization
State Key Laboratory of Chemical Engineering
2016-2025
Tianjin University
2016-2025
Sun Yat-sen University
2025
Membrane Technology & Research (United States)
2025
Hubei University of Chinese Medicine
2023-2024
Qufu Normal University
2024
Kai Biotech (South Korea)
2024
Yunnan University
2020-2023
Tiangong University
2023
South China University of Technology
2023
We report a new paradigm for the rational design of chiral nanostructures that is based on hierarchical self-assembly ferrocene (Fc)-modified dipeptide, ferrocene-l-Phe-l-Phe-OH (Fc-FF). Compared to other self-assembling systems, Fc-FF unique because its smaller size, biocompatibility, multiple functions (a redox center), and environmental responsiveness. X-ray spectroscopic analyses showed incorporation counterions during changed conformations secondary structures from flat β sheets into...
Metal-organic frameworks (MOFs), which are a unique class of hybrid porous materials built from metal ions and organic ligands, have attracted significant interest in recent years as promising platform for controlled drug delivery. Current approaches creating MOFs-based responsive carriers involve encapsulation stimuli-responsive compositions into MOFs or postsynthetic surface modification with sensitive molecules. In this study, we developed novel intrinsic redox-responsive carrier,...
Abstract A novel palladium‐catalyzed CH double carbonylation introduces two adjacent carbonyl groups for the synthesis of isatins from readily available anilines. The reaction proceeds under atmospheric pressure CO with high regioselectivity and without any additives. Density functional theory investigations indicate that catalytic cycle is plausible.
In this study, an artificial hydrolase was developed by combining the catalytic Ser/His/Asp triad with N-fluorenylmethoxycarbonyl diphenylalanine (Fmoc-FF), followed coassembly of peptides into nanofibers (CoA-HSD). The peptide-based provide ideal supramolecular framework to support functional groups. Compared self-assembled (SA-H), which contain only histidine residue, highest activity CoA-HSD occurs when histidine, serine, and aspartate residues are at a ratio 40:1:1. This indicates that...
Abstract A series of dinuclear Ru II complexes with extremely high TPA cross sections in the range 800–900 nm have been designed. The amphiphilic complex Ru3 containing tert‐butyl groups has balanced performance singlet oxygen generation and photothermal conversion becomes ideal drug candidate series. targets mitochondria without penetrating nucleus, which substantially increases its photodynamic therapy activity reduces dark cytotoxicity. successfully suppresses melanoma tumor growth vitro...
The lysosome-targeting chimera (LYTAC) strategy provided a very powerful tool for the degradation of membrane proteins. However, synthesis LYTACs, antibody-small molecule conjugates, is challenging. ability antibody-based LYTACs to penetrate solid tumor limited as well, especially cross blood-brain barrier (BBB). Here, we propose covalent chimeric peptide-based targeted platform (Pep-TACs) by introducing long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking...
In this study, we developed a reflective localized surface plasmon resonance (LSPR) optical fiber sensor, based on silver nanoparticles (Ag NPs). To enhance the sensitivity of LSPR two key parameters were optimized, length sensing area and coating time Ag NPs. A 1.5 cm 1-h proved to be suitable conditions produce highly sensitive sensors for biosensing. The optimized sensor has high refractive index 387 nm/RIU, which is much higher than that other reported individual in solutions. Moreover,...
A supramolecular artificial hydrolase with photo-switchable catalytic activity was developed by the introduction of a photo-responsive group in peptide, which leads to assembly/disassembly peptide nanofibers.
For the first time, we demonstrated fabrication of silver nanoparticles (NPs) in cross-linked protein crystal hybrid material with catalytic properties using a facile chemical reduction method. The macroscopic porous lysozyme crystals can be used as excellent templates for incorporation Ag nanoparticles. resulting AgNP-in-lysozyme composites exhibited good activity toward nitrophenol reduction. Notably, these catalysts could easily recovered and reused at least five successive cycles almost...
A series of cyclometalated Ir(III) complexes with morpholine and piperazine groups are designed as dual photosensitizers photothermal agents for more efficient antitumor phototherapy via infrared low-power laser. Their ground excited state properties, well the structural effect on their photophysical biological investigated by spectroscopic, electrochemical, quantum chemical theoretical calculations. They target mitochondria in human melanoma tumor cells trigger apoptosis related to...
Cross-linked enzyme aggregates (CLEAs) of β-mannanase were prepared by precipitation and subsequent cross-linking. The macromolecular cross-linkers (dialdehyde starch dextran polyaldehyde) with different molecular weight developed instead traditional glutaraldehyde so as to improve the activity CLEAs toward substrates. Scanning electron microscopy revealed that using linear polyaldehyde (MW = 2000 kDa) presented a porous structure low steric hindrance, thus exhibited excellent substrates,...
In this study, a facile one-step synthesis of novel nanocomposite catalytic film was developed based on silver nanoparticles (AgNPs) immobilized in tannic acid-modified eggshell membrane (Tan-ESM). Tannic acid, as typical plant polyphenol from oak wood, first grafted onto ESM fibers to serve both the reductant and stabilizer during AgNPs. The morphology, constitution, thermal stability resulting AgNPs@Tan-ESM composites were fully characterized explain excellent efficiency composites. These...
3D surface-enhanced Raman scattering (SERS) imaging with highly symmetric silver microparticles as a SERS substrate was developed. Although the synthesis method is purely chemical and does not involve lithography, synthesized nanoporous possess regular hexapod shape octahedral symmetry. By using p-aminothiophenol (PATP) probe molecule, enhancement patterns of particles were shown to be very predictable, resembling particle exhibiting An application detection inhomogeneity in polymer blend,...
Nonspecificity and low reproducibility are always the main challenges in surface-enhanced Raman scattering (SERS) detection, especially for testing real samples. In this study, we developed a sandwich-like sensor (AuA-pMIP) to detect rhodamine 6G (R6G) by integrating porous molecularly imprinted polymer (pMIP) with well-ordered AuNP array (AuA). To form uniformly distributed hot spot, AuA was fabricated at an oil-water interface subsequently fixed between pMIP support slide....
Photodynamic therapy (PDT) using two-photon near-infrared light excitation is a very effective way to avoid the use of short-wavelength ultraviolet or visible which cannot efficiently penetrate into biological tissues and harmful healthy cells. Herein, series cyclometalated Ir(III) complexes with structurally simple diimine ligand were designed synthetic route preparation procedure optimized, so that could be obtained in apparently higher yield, productivity, efficiency comparison...
Enzymes play vital roles in catalyzing biochemical reactions with high activity and selectivity, which is largely attributed to the delicately organized structure groups at catalytic domains. Reconstruction of enzymatic domains artificial systems, produce enzyme-like mimic, has become an attractive but challenging subject. Herein, inspired by helical center natural phosphatases, we created a phosphatase-like mimic through self-assembly de novo designed heptapeptides. The heptapeptides were...
Photodynamic therapy (PDT) uses a combination of photosensitizers (PSs), light sources, and reactive oxygen species (ROS) to damage only the desired target keep normal tissues from being hurt. The dark cytotoxicity (chemotoxicity) PSs, leading whole-body in absence irradiation, is major limiting factor PDT. How simultaneously increase ROS generation decrease an essential challenge that must be resolved PS research. In this study, series homoligand polypyridyl ruthenium complexes (HPRCs)...
The S92P/D157A variant of Ideonella sakaiensis PETase ( Is PETase) showed significantly enhanced thermostability and PET degradation activity. W156 residue the was fixed in substrate-binding conformation.
A hetero-dinuclear Ru–Os complex can entirely eradicate PDT-resistant melanoma and cisplatin-resistant non-small cell lung tumors by dual PDT/PTT under an 808 nm low-power laser. It also has low hepatorenal toxicity metal residue in mice.