A5102986930- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
- Cancer and Skin Lesions
- Cytokine Signaling Pathways and Interactions
- Medical Imaging Techniques and Applications
- Cancer therapeutics and mechanisms
- Inflammatory mediators and NSAID effects
- Pancreatic and Hepatic Oncology Research
- Cancer-related molecular mechanisms research
- Breast Lesions and Carcinomas
- Helminth infection and control
- Cancer Research and Treatments
- Bone health and treatments
Kanion Pharmaceutical (China)
2025
Sun Yat-sen University
2025
Sichuan University
2015-2024
West China Hospital of Sichuan University
2015-2024
Chonnam National University
2024
Hohai University
2024
State Key Laboratory of Oral Diseases
2021-2023
Wuhan University of Technology
2022
Wuhan University
2020
Mianyang Central Hospital
2020
<h3>Importance</h3> Although the incidence and prevalence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) have been thought to increased during past decades, updated epidemiologic survival data are lacking. <h3>Objectives</h3> To conduct an analysis largest cohort patients with GEP-NETs using latest establish a novel nomogram predict probability individual GEP-NETs. <h3>Design, Setting, Participants</h3> In this study, 43 751 diagnosed from January 1, 1975, December 31, 2015, were...
The lysosome-targeting chimera (LYTAC) strategy provided a very powerful tool for the degradation of membrane proteins. However, synthesis LYTACs, antibody-small molecule conjugates, is challenging. ability antibody-based LYTACs to penetrate solid tumor limited as well, especially cross blood-brain barrier (BBB). Here, we propose covalent chimeric peptide-based targeted platform (Pep-TACs) by introducing long flexible aryl sulfonyl fluoride group, which allows proximity-enabled cross-linking...
Laparoscopic liver resection has not been widely used because of intraoperative bleeding. This problem should be solved with instruments and techniques that require a short learning curve.The aim this work was to present the technique in our center perform laparoscopic using 'curettage aspiration' Peng's multifunctional operational dissectors regional occlusion inflow outflow. We retrospectively analyzed patients who underwent from August 1998 2012, collected conversion rate, operating time,...
Zoledronic acid is the most potent osteoclast inhibitor and widely used for advanced cancer patients with bone metastasis, but its role on stem cells (CSCs) remains unclear. In present study, we aimed to identify stemness phenotypic characteristics of CSCs derived from cervical explore anti-cancer efficiency zoledronic these cells, as well possible molecular mechanisms.Stemness identification was performed via sphere formation (SFE), tumorigenesis, immunofluorescence staining, Transwell...
Epithelial-mesenchymal transition (EMT) is a crucial driver of tumor progression. Tumor growth factor-beta 1 (TGF-β1) an important factor in EMT induction tumorigenesis. The targeting may, therefore, represent promising approach anticancer treatment.In this study, we determined the effect decitabine, DNA methyltransferase inhibitor, on TGF-β1-induced non-small-cell lung cancer (NSCLC) PC9 and A549 cells. We also assessed involvement miR-200/ZEB axis.Decitabine reversed cells, but not This...
The combination of some parameters, including the neutrophil to lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR) and (NMR), which are associated with patient prognosis, our goal is find best indicator predict efficacy neoadjuvant chemotherapy（NAC）in breast cancer patients. A cohort 808 patients treated NAC subsequent surgery was analyzed retrospectively. In addition, 2424 people without served as normal group, included three-fold more individuals compared group. Receiver operating...
In clinical practice, thymopentin (TP‐5) is a commonly utilized immunomodulatory peptide drug. The relatively short half‐life of TP‐5, however, significantly limits its applicability in immunotherapy. Inspired by the structure TLR2 ligand lipopeptide Pam3CSK4, fatty acid‐modified TP‐5 peptides were designed and synthesized this study. Utilizing amphiphilicity, they sonicated to assemble into nanoparticles with diameters approximately 100 nm. Compared monopalmitate‐modified nanoparticle has...
To extract intratumoral, peritumoral, and integrated intratumoral-peritumoral CT radiomic features, develop multi-source models using various machine learning algorithms to identify the optimal model, integrate clinical factors establish a nomogram for predicting therapeutic response induction therapy(IT) in locally advanced non-small cell lung cancer. This study included 209 patients with cancer (LA-NSCLC) who received IT as training cohort, an external validation cohort comprising 50 from...
Polysaccharides, vital biological macromolecules ubiquitous in organisms, have garnered attention as potential therapeutic candidates for ulcerative colitis (UC). However, the of Rhodiola crenulata polysaccharides (RCP) UC remains largely unexplored. The RCP was prepared by boiling water extraction, 80% alcohol precipitation, membrane separation, and D101 macroporous resin purification. monosaccharide composition (Mw = 67.848 kDa) includes mannose, rhamnose, glucuronic acid, galacturonic...
Purpose: ACT001 is a novel sesquiterpene lactone derivative with anticancer effects, including the reversal of tamoxifen resistance in estrogen receptor-positive breast cancer cells. However, few studies have investigated effects triple-negative (TNBC), highly aggressive poor prognosis. This study aimed to investigate on TNBC and potential mechanism underlying these effects. Materials Methods: The murine cell line 4T1 were evaluated by Cell Counting Kit-8 assay, animal experiments, TUNEL...
Abstract EGFR exon 20 insertion (20ins)-positive non-small-cell lung cancer (NSCLC) is an uncommon disease with limited therapeutic options and dismal prognosis. Here we report the activity, tolerability, potential mechanisms of response resistance for dual targeting 20ins JMT101 (anti-EGFR monoclonal antibody) plus osimertinib from preclinical models open label, multi-center phase 1b trial (NCT04448379). Primary endpoint tolerability. Secondary endpoints include objective rate, duration...
Background: Breast cancer is the leading cause of mortality from in women worldwide, and stem-like cell (CSC) responsible for failure treatment breast cancer. It plays an important role resistant disease metastasis. CD44/CD24 ALDH are well-accepted protein markers CSC, it was reported that distinct subtypes CSC were identified by 2 markers. possible there various kinds which could be different markers, utilized at present not enough to fully understand CSC. Finding out more novel necessary....
Background Aberrant Rad51 expression is implicated in the progression of human malignancies. However, role colorectal cancer (CRC) remains undefined. This study aimed to establish a relationship between and clinicopathologic features CRC. Methods We retrospectively examined paraffin-embedded tissue samples obtained from 54 patients with CRC who had received surgical therapies at our institution during 2006–2008. adenocarcinoma, paracancerous tissue, normal colonic was determined by...
Background: With a high frequency of 30%, KRAS mutations in patients with non-small cell lung cancer (NSCLC) often lead to their poor response most anti-cancer therapies. As multi-target tyrosine kinase inhibitor, Anlotinib shows clinical efficacy against several types cancer. However, its effects on mutant NSCLC and the underlying molecular mechanisms remain unclear. Materials Methods: Cell counting Kit-8 assay, colony formation flow cytometry analysis, wound healing scratch Transwell assay...
Objectives The purpose of this study was to compare the use sonography and non–contrast-enhanced magnetic resonance imaging (MRI) for detection staging glottic carcinoma. Methods In study, 30 consecutive patients with squamous cell carcinoma underwent high-frequency MRI before surgical treatment. Tumor detectability findings were evaluated independently then compared postoperative pathologic findings. Results Sonography showed a trend toward higher than in early (stage T1 T2) (94.1% [16 17...
Previous studies have demonstrated that aspirin serves an important role in chemoprevention and the suppression of colorectal cancer (CRC); however, underlying mechanisms for this inhibition by remain unclear. Aspirin is capable promoting apoptosis through prostaglandin‑dependent orprostaglandin‑independent signaling pathways. In pathways, cyclooxygenase (COX), particularly COX‑2, primary mechanism known to be involved aspirin‑induced CRC suppression. implicated prostaglandin‑independent...