A5101533894- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Pituitary Gland Disorders and Treatments
- Neuroendocrine Tumor Research Advances
- Gestational Diabetes Research and Management
- Cancer Genomics and Diagnostics
- Diabetes Management and Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Pancreatic function and diabetes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cancer Cells and Metastasis
- Birth, Development, and Health
- Diet and metabolism studies
- Cancer Immunotherapy and Biomarkers
- Diabetes and associated disorders
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
- Gout, Hyperuricemia, Uric Acid
- Hormonal Regulation and Hypertension
- Diabetes Management and Education
Nanjing University
2021-2025
Peking Union Medical College Hospital
2010-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2023
Simcere Pharmaceutical (China)
2023
Second Military Medical University
2012-2023
Eastern Hepatobiliary Surgery Hospital
2012-2023
Guangxi Medical University
2021
National Health and Family Planning Commission
2018-2021
The Second Affiliated Hospital of Bengbu Medical College
2018
Shanghai Ninth People's Hospital
2017-2018
Microvascular invasion (MVI) is presently evaluated as a high-risk factor to be directly relative postoperative prognosis of hepatocellular carcinoma (HCC). Up now, diagnosis MVI mainly depends on the pathological analyses with H&E staining assay, based numbers and distribution characteristics classify risk levels MVI. However, such lack specificity discriminate in HCC specimens, especially complicated tissues. In addition, efficiency precisely define stages not satisfied. Thus, any...
The combination of some parameters, including the neutrophil to lymphocyte ratio (NLR), platelet (PLR), monocyte (LMR) and (NMR), which are associated with patient prognosis, our goal is find best indicator predict efficacy neoadjuvant chemotherapy（NAC）in breast cancer patients. A cohort 808 patients treated NAC subsequent surgery was analyzed retrospectively. In addition, 2424 people without served as normal group, included three-fold more individuals compared group. Receiver operating...
The aim of this study was to investigate the oncogenic function and regulatory mechanism stathmin in oral squamous cell carcinoma (OSCC). Two-dimensional electrophoresis liquid chromatography-tandem mass chromatography were applied screen differentiated proteins during carcinogenesis OSCC. Cell Counting Kit-8 (CCK-8) assays, colony formation, migration, flow cytometry, immunofluorescence a xenograft model used detect stathmin. correlation between p53 expression analyzed using...
Malignant insulinoma is extremely rare and accounts for only 10% of total cases. The goal this study to retrospectively analyze clinical data from 15 patients with malignant treated at Peking Union Medical College Hospital (PUMCH) 1984 April 2017. "Malignant insulinoma" was used as the keywords in PUMCH medical record retrieval system search obtain patients' information. We identified subjects diagnosed based on or surgical pathological signs subsequently analyzed their data. Eight males...
To investigate effects of metformin on the regulation proteins white adipose tissue (WAT) and brown (BAT) in obesity explore underlying mechanisms energy metabolism.C57BL/6J mice were fed with normal diet (ND, n = 6) or high-fat (HFD, 12) for 22 weeks. HFD-induced obese treated (MET, 6). After treatment 8 weeks, oral glucose tolerance test (OGTT) hyperinsulinemic-euglycemic clamp performed to evaluate improvement insulin sensitivity. Protein expressions WAT BAT among ND, HFD, MET group...
Carboplatin, a second-generation platinum chemotherapeutic drug, is considerably less ototoxic than cisplatin. While common laboratory species such as mice, guinea pigs and rats are highly resistant to carboplatin ototoxicity, the chinchilla stands out susceptible. Moreover, causes an unusual gradient of cell death in chinchillas. Moderate doses selectively damage type I spiral ganglion neurons (SGN) inner hair cells (IHC) lesion tends be relatively uniform along length cochlea. Higher...
High-fat diet (HFD) leads to the development of obesity accompanied by insulin resistance, which increases risk type 2 diabetes mellitus and cardiovascular disease. Brown adipose tissue (BAT) plays an essential role in energy metabolism, thus it will give us promising treatment targets through elucidating underlying mechanisms BAT obesity. In this study, female C57BL/6J mice were fed HFD or normal (ND) for 22 weeks. Hyperinsulinemic-euglycemic clamp was performed evaluate sensitivity,...
Survivin is an inhibitor of apoptosis protein, which selectively up-regulated in various cancers including esophageal cancer. The underlying mechanism survivin overexpression still unclear. We investigated resected tumor specimens from 100 cancer patients. Reverse transcription polymerase chain reaction was performed to evaluate gene expression. Polymerase reaction-single strand conformation polymorphism investigate mutations p53. found that the expression tumors with mutant p53 higher than...
Lentivirus carrying the Atoh1 gene can infect Corti's organ and express a hair-like cell surface marker in supporting area. However, expression of carried by adenovirus is instantaneous, which undoubtedly limits its clinical application. acts as carrier that stably continuously genes. In this study, cochlear structure hearing level were not affected, lentivirus promoted production cells This led to myosin 7a 30 days after was microinjected into round window rats.
Purpose To find the potential biomarkers in diagnostic model of oral and squamous cell carcinoma (OSCC), to further validate biomarker. Experimental design With MALDI–TOF–MS analysis between tissues from cancer patients normal mucosa healthy controls, scavenger receptor class A member 5 (scara5) is found be potentially significant after searching protein database. In addition, Immunohistochemical staining, PCR, ELISA, Western blot technique are used detect scara5 expression clinical samples...
Abstract Background We aimed to evaluate the effects of short-term therapy with dapagliflozin on serum uric acid (SUA) and urinary (UUA) levels in patients type 2 diabetes. Methods In this prospective pilot trial, 8 diabetes mellitus were assigned treatment group 10 mg once daily for one week, 7 subjects normal glucose tolerance recruited into control group. Data anthropometric measurements, SUA, 24-h UUA, fractional excretion UA (FEUA), lipid parameters 3-h oral test (OGTT) collected both...
Cardiac autonomic neuropathy is a common but always overlooked. More convenient diagnostic methods are needed.Cardiac risk score evaluated by SUDOSCAN has fine efficacy detecting cardiac neuropathy.This cross-sectional study among patients with diabetes mellitus. Subjects undertook tests and reflex tests, including heart rate variability due to Valsalva maneuver, response deep breathing standing up. Presenting 2 abnormal results was defined as neuropathy.Subjects significantly higher...
INTRODUCTION Acute intermittent porphyria (AIP) is an autosomal dominant inborn error of metabolism caused by deficiency porphobilinogen (PBG) deaminase, also known as hydroxymethylbilane synthase (HMBS), the third enzyme in heme biosynthetic pathway. The clinical features AIP are attributed to depletion and accumulation intermediates PBG aminolevulinic acid (ALA), proximal defect.[1] Multiple organ systems can be affected patients with AIP. typical attacks characterized gastrointestinal...
Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in oral and maxillofacial regions, with a high rate of metastasis. Cancer-associated fibroblasts (CAFs) play critical roles growth, metastasis invasion, making them attractive therapeutic targets for cancer treatment. As an old anti-coccidiosis drug poultry, Halofuginone (HF) has also been reported to possess anti-fibrosis anti-cancer activities recent decades. However, whether it works by targeting CAFs OSCC, mechanisms...
White adipose tissue (WAT) plays a significant role in energy metabolism and the obesity epidemic. In this study, we sought to (1) profile mouse WAT proteome with advanced 2DLC/MS/MS approach, (2) provide insight into function based on protein functional annotation, (3) predict potentially secreted proteins. A label-free proteomic approach was used identify from female WAT. total of 6,039 proteins were identified, among which 5,160 quantified (spanning magnitude 106) using an intensity-based...
Knowledge about the mouse brown adipose tissue (BAT) proteome can provide a deeper understanding of function mammalian BAT. Herein, comprehensive analysis interscapular BAT from C57BL/6J female mice was conducted by 2DLC and high-resolution mass spectrometry to construct dataset proteins. A total 4949 nonredundant proteins were identified, 4495 quantified using iBAQ method. According values, divided into high-, middle- low-abundance The functions high-abundance mainly related glucose fatty...
Oxaliplatin, an anticancer drug commonly used to treat colorectal cancer and other tumors, has a number of serious side effects, most notably neuropathy ototoxicity. To gain insights into its ototoxic profile, oxaliplatin was applied rat cochlear organ cultures. Consistent with it neurotoxic propensity, selectively damaged nerve fibers at very low dose 1 μM. In contrast, the required damage hair cells spiral ganglion neurons 50 fold higher (50 μM). Oxailiplatin-induced lesions initially...
Our previous phase 3 trial (NCT01542931) failed to demonstrate improved survival when docetaxel, cisplatin and 5‑fluorouracil (TPF) induction chemotherapy was introduced prior surgery postoperative radiotherapy in patients with locally advanced oral squamous cell carcinoma (OSCC). The aim of the present study investigate long‑term predictive value GDF15 expression for potential personalized treatment strategies OSCC. A total 256 stage III/IVA OSCC from our were enrolled study....
The dysregulation of arrestin domain containing 3 (ARRDC3) has an important effect on oncogenesis and tumor progression in many cancers, including renal cell carcinoma breast cancer. However, the role ARRDC3 ovarian cancer (OC) not been reported.The present study explored diagnostic prognostic roles using GEPIA, ONCOMINE, GEO, Kaplan-Meier Plotter databases for training validation. Then, we conducted a stratified analysis clinicopathological factors GEPIA databases. To further explore...