A5100669734- Molecular Sensors and Ion Detection
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Advanced biosensing and bioanalysis techniques
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Ear and Head Tumors
- CAR-T cell therapy research
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Bone Tumor Diagnosis and Treatments
- Luminescence and Fluorescent Materials
- Glioma Diagnosis and Treatment
- Berberine and alkaloids research
- RNA Interference and Gene Delivery
- Cutaneous Melanoma Detection and Management
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Electrochemical Analysis and Applications
- Vascular Malformations and Hemangiomas
- Monoclonal and Polyclonal Antibodies Research
- Head and Neck Anomalies
- Advanced Radiotherapy Techniques
- Osteoarthritis Treatment and Mechanisms
- Advanced MRI Techniques and Applications
Qilu University of Technology
2018-2025
Shandong Academy of Sciences
2018-2025
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2020-2025
Shandong First Medical University
2020-2025
Shandong Tumor Hospital
2020-2025
Tsinghua University
2024
Shanghai Jiao Tong University
2014-2024
Shanghai Ninth People's Hospital
2015-2024
Chinese Academy of Sciences
2005-2024
Nanjing Medical University
2024
Parkinson's disease (PD), a progressive neurodegenerative characterized by bradykinesia, rigidity, and resting tremor, is the most common movement disorder. Although majority of PD cases are sporadic, some inherited, including those caused leucine-rich repeat kinase 2 (LRRK2) mutations. The substitution serine for glycine at position 2019 (G2019S) in domain LRRK2 represents prevalent genetic mutation both familial apparently sporadic PD. Because mutations likely associated with toxic gain...
Abstract Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play important roles in cancer stemness, respectively. However, little is known about interaction between CAFs PTK7 cancers. In this study, we showed that was significantly correlated with the Wnt/β-Catenin pathway aggressive clinicopathologic features human head neck squamous cell carcinoma (HNSCC). Meanwhile, animal experiments enhanced chemoresistance lung metastasis of HNSCC vivo. addition,...
Currently, there is no curative treatment for inflammatory bowel disease (IBD), which has an increased risk of colitis-associated cancer. Corticosteroids are the main clinical IBD therapeutics but have significant side effects. Even heavy corticosteroid use can result in failure may lead to resective surgery. In this study, we designed one type new drug-delivery system (DDS) delivering dexamethasone (DEX), anti-inflammation corticosteroid, therapy. This DDS was screened by...
Abstract Osteoarthritis (OA) is a disabling joint disease associated with chronic inflammation. The polarization of macrophages plays the key role in inflammatory microenvironment which therapeutic target for OA treatment. Herein, boronate‐stabilized polyphenol–poloxamer assembled dexamethasone nanodrug reactive oxygen species (ROS)‐responsive drug release behavior and ROS scavenging ability prepared. Thanks to that, can efficiently inhibit nitric oxide production...
Nonfluorescent succinimides become fluorescent only by thiol and amine group substitutions, without employing any units.
Patients with advanced head and neck squamous cell carcinoma (HNSCC) have a poor prognosis the currently available therapy, tumor recurrence is frequently observed. The discovery of specific membrane-associated cancer stem (CSC) markers crucial for development novel therapeutic strategies to target these CSCs. To address this issue, we established sphere cultures enrich CSCs used them plasma membrane proteomics identify signatures HNSCC spheres. Of dataset that included total 376 identified...
Abstract Self‐assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol poloxamer self‐assemble (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid Pluronic F‐127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied tumor near‐infrared fluorescence (NIRF) imaging positron emission tomography (PET) imaging. With fluorescent dyes such as IR780...
Objective: Ciprofol is a novel 2,6-disubstituted phenol derivative that has improved pharmacokinetic and pharmacodynamic properties compared with propofol. This study was conducted to compare the efficacy safety of ciprofol-remifentanil versus propofol-remifentanil for patients undergoing fiberoptic bronchoscopy. Methods: Overall, 92 bronchoscopy were included in this prospective, randomized, double-blind, non-inferiority trial equally divided into two groups (n = 46 each). Fentanyl (50 μg)...
Abstract The use of radiolabeled cells for positron emission tomography (PET) imaging tracking has been a promising approach monitoring cell‐based therapies. However, the presence free radionuclides released from dead during can interfere with signal living cells, leading to inaccurate results. In this study, effectiveness iron chelators deferoxamine (DFO) and deferiprone in removing 89 Zr 68 Ga, respectively, was demonstrated vivo utilizing PET imaging. DFO Zr‐labeled mesenchymal stem...
Glioblastoma is the most common and deadly primary brain tumor in adults. Low-dose,metronomic (LDM) temozolomide (TMZ) displays improved efficacy treatment of glioblastoma by targeting angiogenesis, but has a limited effect on recurrence. The antiangiogenesis drug ginsenoside Rg3 (RG3) main active ingredient ginseng, popular herbal medicine. Using an vitro rat model orthotopic glioma allograft, this study was to determine whether RG3 enhanced activity LDM TMZ glioblastoma. Our results showed...
Particles with a porous structure can lead to quick hemostasis and provide good matrix for cell proliferation during wound healing.
Marine natural products are important sources of novel drugs. In this study, we isolated 4-hydroxyphenylacetic acid (HPA) from the marine-derived fungus Emericellopsis maritima Y39–2. The antithrombotic activity and mechanism HPA were reported for first time. Using a zebrafish model, found that had strong because it can significantly increase cardiac erythrocytes, blood flow velocity, heart rate, reduce caudal thrombus, reverse inflammatory response caused by Arachidonic Acid (AA). Further...
The scorpion Buthus martensii Karsch is edible and has been an essential resource in traditional Chinese medicine for treating numerous diseases. In this study, two small peptides from B. hydrolysates were examined to elucidate their potential against gastric cancer. (AK GK) identified using the LC-QTOF-MS-based approach. silico prediction of therapeutic targets, MGC-803 cells transgenic zebrafish models, immunoblotting experiments used reveal molecular mechanism action peptides. AK GK...