A5100758981- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Peptidase Inhibition and Analysis
- RNA Interference and Gene Delivery
- Neuroscience and Neuropharmacology Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Gold and Silver Nanoparticles Synthesis and Applications
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Luminescence and Fluorescent Materials
- Cancer, Hypoxia, and Metabolism
- Antimicrobial Peptides and Activities
- Educational Reforms and Innovations
- Iron Metabolism and Disorders
- Pharmacological Receptor Mechanisms and Effects
- Coastal and Marine Management
- High-Velocity Impact and Material Behavior
- Advanced Photocatalysis Techniques
- Circular RNAs in diseases
- Polydiacetylene-based materials and applications
- Medical Imaging Techniques and Applications
- ATP Synthase and ATPases Research
- Neuropeptides and Animal Physiology
Nanjing Medical University
2023-2025
Fujian Institute of Research on the Structure of Matter
2023
Chinese Academy of Sciences
2023
Beibu Gulf University
2022-2023
Development Research Center
2022-2023
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2019-2023
Beijing University of Chemical Technology
2021-2023
National Health and Family Planning Commission
2023
Yale Cancer Center
2020-2022
Yale University
2020-2022
Glial cells are thought to supply energy for neurotransmission by increasing nonoxidative glycolysis; however, oxidative metabolism in glia may also contribute increased brain activity. To study glial contribution cerebral the unanesthetized state, we measured neuronal and metabolic fluxes awake rat using a double isotopic-labeling technique two-compartment mathematical model of neurotransmitter metabolism. Rats (n = 23) were infused simultaneously with 14C-bicarbonate [1-13C]glucose up 1...
Currently, there is no curative treatment for inflammatory bowel disease (IBD), which has an increased risk of colitis-associated cancer. Corticosteroids are the main clinical IBD therapeutics but have significant side effects. Even heavy corticosteroid use can result in failure may lead to resective surgery. In this study, we designed one type new drug-delivery system (DDS) delivering dexamethasone (DEX), anti-inflammation corticosteroid, therapy. This DDS was screened by...
Ferroptosis and autophagy are the two forms of regulation cell death that play important roles in cancer therapy. However, little is known about combination therapeutic effects ferroptosis Here, this study, we constructed a novel carrier-free nanodrug called nanoparticle ferritin-bound erastin rapamycin (NFER). The NFER was prepared by emulsification technique; it exhibited an average size 78.8 nm zeta potential -25.9 ± 3.3 mV. Controllable drug encapsulation efficiency loading ratios could...
Rationale: Anti-tumor necrosis factor (TNF) therapy is a very effective way to treat inflammatory bowel disease. However, systemic exposure anti-TNF-α antibodies through current clinical administration can cause serious adverse effects in many patients. Here, we report facile prepared self-assembled supramolecular nanoparticle based on natural polyphenol tannic acid and poly(ethylene glycol) containing polymer for oral antibody delivery. Method: This was fabricated within minutes aqueous...
Nonfluorescent succinimides become fluorescent only by thiol and amine group substitutions, without employing any units.
Abstract Self‐assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol poloxamer self‐assemble (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid Pluronic F‐127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied tumor near‐infrared fluorescence (NIRF) imaging positron emission tomography (PET) imaging. With fluorescent dyes such as IR780...
Various functional nanomaterials have been fabricated as diagnostic and therapeutic nanomedicines; however, the nanoparticles closely interact with proteins when immersed in biological fluids, forming a "protein corona" that critically alters identity of nanomedicine. Here, we developed robust strategy to construct theranostic nanoprobes based on protein-corona-coated Fe3O4 biomineralization corona. Water-soluble carboxylic were prepared by treating oleate-capped Lemieux–von Rudloff reagent....
This study was conceived in an effort to understand cause and effect relationships between hyperglycemia diabetic retinopathy. Numerous studies show that leads oxidative stress the retinas, but mechanisms generate have not been resolved. Increased electron pressure on mitochondrial transfer chain, increased generation of cytosolic NADH, decreases cellular NADPH all cited as possible sources reactive oxygen species nitrous oxide. In present study, excised retinas from control rats were...
A novel immune checkpoint, FGL1, is a potentially viable target for tumor immunotherapy. The development of FGL1-targeted PET probes could provide significant insights into the system's status and evaluation treatment efficacy. ClusPro 2.0 server was used to analyze interaction between FGL1 LAG3, candidate peptides were identified by using Rosetta peptide derivate protocol. Three targeting named FGLP21, FGLP22, FGLP23, with simulated affinity −9.56, −8.55, −8.71 kcal/mol, respectively,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: Crystal structure yeast Ubc4William J. Cook, Leigh C. Jeffrey, Yuping Xu, and Vincent ChauCite this: Biochemistry 1993, 32, 50, 13809–13817Publication Date (Print):December 1, 1993Publication History Published online1 May 2002Published inissue 1 December 1993https://pubs.acs.org/doi/10.1021/bi00213a009https://doi.org/10.1021/bi00213a009research-articleACS...
The mitochondrial transporter, the aspartate/glutamate carrier (AGC), is a necessary component of malate/aspartate cycle, which promotes transfer into mitochondria reducing equivalents generated in cytosol during glycolysis. Without cytosolic mitochondria, neither glucose nor lactate can be completely oxidized. In present study, immunohistochemistry was used to demonstrate absence AGC from retinal glia (Müller cells), but its presence neurons and photoreceptor cells. To determine influence...
DOX loaded ferritin selectively induces ferroptosis enhanced killing of transferrin receptor 1 overexpressed cancer cells.
BACKGROUND:MiRNAs play important roles in regulating many fundamental biological processes. Deregulation of miRNAs is involved the initiation and progression cancer. MiR-193b regarded as tumor suppressor types cancers. However, role miR-193b ovarian cancer poorly understood. MATERIAL AND METHODS:The expression level cell lines samples was evaluated using quantitative real-time reverse transcription-PCR (qRT-PCR). The patients were categorized into a high group low according to median level....
Combining aminolysis of thiolactones and amine-maleimide Michael addition contributed to the synthesis fluorescent aliphatic poly(amide-imide)s, accomplishing excellent solubility <italic>via in situ</italic> PEGylation.
Fluorinated polymers have attracted increasing attention in gene delivery and cytosolic protein recent years. In vivo tracking of fluorinated will be great importance to evaluate their biodistribution, clearance, safety. However, polymeric carriers without changing chemical structures remains a huge challenge. Herein, we reported series poly-l-(lysine) (F-PLL) with high transfection efficiency excellent biodegradation. Radionuclide 18F was radiolabeled on F-PLL by halogen replacement...
Improving iron-chelating drugs for the safe and efficient therapy of iron overload disease is greatly challenging highly desired. Endogenous chelators are perfect candidates because their intrinsic biodegradability biocompatibility, which avoid severe side effects exogenous currently present in clinical applications. Herein, first time, we have reported simply using melanin nanoparticles as an natural nano-drug living mice. Its native biodegradability, high iron-capturing volume long...
Abstract Advanced chemotherapeutic strategies including prodrug and nanocatalytic medicine have significantly advanced tumor‐selective theranostics, but delicate screening, tedious synthesis, low degradability/biocompatibility of inorganic components, unsatisfied reaction activity complicate treatment efficacies. Here, the intrinsic anticancer bioactivity liquid metal nanodroplets (LMNDs) is explored through galvanic replacement. By utilizing a mechano‐degradable ligand, resultant size...
Abstract As well known in bioactives delivery and cancer/inflammation theranostics, polycations have recently extended their biomedical potentials reducing visceral fat, embolizing body fluid, modulating blood coagulation, ameliorating hyperammonemia. However, positive charges that dominate various action mechanisms, often raise risks biosafety concerns. Also, the lack of intrinsic imaging properties makes it challenging to uncover pharmacokinetic profiles living objects. Herein, dopamine...