A5003559708- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Ferroptosis and cancer prognosis
- Gold and Silver Nanoparticles Synthesis and Applications
- Cerebrovascular and Carotid Artery Diseases
- Porphyrin and Phthalocyanine Chemistry
- Advanced Nanomaterials in Catalysis
- Cancer Research and Treatments
- Cancer, Lipids, and Metabolism
- Antibiotic Resistance in Bacteria
- Metal-Catalyzed Oxygenation Mechanisms
- Immunotherapy and Immune Responses
- Quantum Dots Synthesis And Properties
- Nanocluster Synthesis and Applications
- Acute Ischemic Stroke Management
- Biomarkers in Disease Mechanisms
- Lanthanide and Transition Metal Complexes
- Graphene and Nanomaterials Applications
- Immune cells in cancer
- Tryptophan and brain disorders
- Metal complexes synthesis and properties
- RNA Interference and Gene Delivery
First Hospital of Jilin University
2024
Jilin University
2024
Beijing University of Chemical Technology
2021-2023
Chinese Academy of Sciences
2022
Institute of Chemistry
2022
Henan University of Technology
2019
Nanovaccines have emerged as promising alternatives or complements to conventional cancer treatments. Despite the progresses, specific co-delivery of antigen and adjuvant their corresponding intracellular destinations for maximizing activation antitumor immune responses remains a challenge. Herein, lipid-coated iron oxide nanoparticle is delivered nanovaccine (IONP-C/O@LP) that can co-deliver peptide (CpG DNA) into cytosol lysosomes dendritic cells (DCs) through both membrane fusion...
Improving the effectiveness of cancer therapy will require tools that enable more specific targeting and improved tumor visualization. Theranostics have potential for improving care because their ability to serve as both diagnostics therapeutics; however, diagnostic is often limited by tissue-associated light absorption scattering. Herein, we develop CuInSe2@ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality accurate localization small metastases act potent ablation agents. By...
Various functional nanomaterials have been fabricated as diagnostic and therapeutic nanomedicines; however, the nanoparticles closely interact with proteins when immersed in biological fluids, forming a "protein corona" that critically alters identity of nanomedicine. Here, we developed robust strategy to construct theranostic nanoprobes based on protein-corona-coated Fe3O4 biomineralization corona. Water-soluble carboxylic were prepared by treating oleate-capped Lemieux–von Rudloff reagent....
Abstract Background Although the promising advancements of current therapeutic approaches is available for squamous cell carcinoma (SCC) patients, clinical treatment SCC still faces many difficulties. The surgical irreparable disfigurement and postoperative wound infection largely hamper recovery, chemo/radiotherapy leads to toxic side effects. Results Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe Fe III TA@HA has been designed through biomineralization 3+...
Abstract The diagnosis and treatment of triple‐negative breast cancer (TNBC) is still a grand challenge, because there rare target to be manipulated. Here, an integrated functional nanoprobe developed for precise TNBC, based on biominerals Fe 3+ rutin hydrate (RH), type natural flavonoid. Owing the adjacent phenol hydroxyl groups RH, can biomineralize with RH form colloidally stabilized by coating poly(vinyl pyrrolidone) (PVP). In nanoprobe, flavonol central scaffold as well glucoside...
The dysregulated macrophage phenotype, as the main cause of colitis, not only enhanced oxidative stress to exacerbate inflammatory responses but was closely related with gut microbial dysbiosis. It needed simultaneously address three issues for effective treatment it satisfied. Here, we developed "three-birds-one-stone" probiotics, named Se@EcN-C2/A2, colitis treatment. Escherichia coli Nissle 1917 (EcN), a clinically approved probiotic, used intracellularly synthesize selenium (Se)...
Enhanced angiography based on magnetic resonance imaging (MRI) has emerged as a noninvasive, robust, and high-resolution technique for the clinical evaluation of vascular diseases. However, effects Gd-chelating contrast agents are unsatisfactory MRI enhancement owing to their short blood half-life caused by rapid extravasation, especially in microvessels. To address these issues, nanoprobes red cell membrane-coated ultrasmall NaGdF4 nanoparticles that exhibit much higher longitudinal molar...
Mesoporous silica nanoparticles have been extensively explored in anticancer nanomedicine due to their excellent biodegradability, which is one important focus further clinical translations. However, the traditional design concepts based on functional modification with active groups cannot significantly improve controlled drug release efficiency and effect. Herein, a molecularly organic–inorganic hybrid mesoporous nanoparticle (HMSN) nanocarrier coated hyaluronic acid (HA) polyethyleneimine...
In this study, we prepared new lignin-based pH-responsive nanoparticles (LG-M(N)-PEG NPs) and their conjugates (LG-M(N-DOX)-PEG by using polyethylene glycol (PEG), doxorubicin (DOX), alkaline lignin. these NPs, the PEG chains were conjugated to lignin an UV irradiated thiol–ene click reaction. The hydrazine β-thiopropionate bonds in NPs could conduct pH-triggered release of both DOX at acidic pH tumor cells. Results showed that LG-M(N-DOX)-PEG had a moderate particle size (48.3 ± 3.2 nm),...
Ischemic stroke is one of the leading causes disability and mortality. The collaterals provide an alternative pathway to preserve ischemic brain tissue, determine penumbra range, where neurons are salvageable. Therefore, accurately monitoring identifying crucial. Herein, a low-immunogenic nanoprobe-based MRI strategy developed simultaneously identify infarct core, distribution, distributions. nanoprobe was constructed by covalently attaching self-peptide on surface biocompatible Fe3O4...
We proposed a GSH-responsive mesoporous organosilica nanoparticles-based nanomedicine that can target tumor mitochondria. The induce apoptosis and immunogenic death of cells, realizing the chemodynamic immunological therapy cancer.
The effect of surface charge on the tumor-targeting in vivo is different from that at cell level. neutral nanoparticles exhibit stronger tumor uptake, while charged ones accelerate RES/MPS making their active-targeting useless.
Abstract Depression is a prevalent mental illness that imposes substantial public health burden. However, the diverse clinical phenotypes observed in patients make it difficult to realize precise diagnosis. Recently, accumulating preclinical and evidence has suggested inflammation involved pathophysiology of depression. Herein, molecular imaging–based strategy was proposed as means diagnose depression precisely by specifically visualizing status associated with Inflammation-targeting MRI...
Polymyxin B (PMB) exert bactericidal effects on the cell wall of Gram-negative bacteria, leading to changes in permeability cytoplasmic membrane and resulting death, which is sensitive multi-resistant bacteria. However, severe toxicity adverse side largely hamper clinical application PMB. Although molecular pathology PMB neurotoxicity has been adequately studied at cellular level. impact physiological states central nervous system vivo may be quite different from that vitro, need further...
Colon adenocarcinoma (COAD) represents a significant health concern within the population. Advancing our understanding of COAD is imperative for early detection, enabling personalized treatment interventions, and facilitating development effective preventive measures. The coagulation system plays role in tumor-related pathological processes; however, its specific involvement potential contributors remain unclear. This study aimed to establish novel risk stratification approach by analyzing...