A5070917604- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Lanthanide and Transition Metal Complexes
- Optical Network Technologies
- Extracellular vesicles in disease
- Neural Networks and Reservoir Computing
- Porphyrin and Phthalocyanine Chemistry
- Graphene and Nanomaterials Applications
- Cerebrovascular and Carotid Artery Diseases
- Semiconductor Lasers and Optical Devices
- Pediatric Urology and Nephrology Studies
- Cerebrospinal fluid and hydrocephalus
- Immune cells in cancer
- Advanced Nanomaterials in Catalysis
- Cellular Automata and Applications
- Metal-Catalyzed Oxygenation Mechanisms
- Photonic and Optical Devices
- Advanced Photonic Communication Systems
- Semiconductor Quantum Structures and Devices
- Metal complexes synthesis and properties
- Traumatic Brain Injury and Neurovascular Disturbances
- Gold and Silver Nanoparticles Synthesis and Applications
- Acute Ischemic Stroke Management
Wuhan National Laboratory for Optoelectronics
2024
Huazhong University of Science and Technology
2024
Beijing University of Chemical Technology
2021-2024
Abstract Multimodal deep learning plays a pivotal role in supporting the processing and of diverse data types within realm artificial intelligence generated content (AIGC). However, most photonic neuromorphic processors for can only handle single modality (either vision or audio) due to lack abundant parameter training optical domain. Here, we propose demonstrate trainable diffractive neural network (TDONN) chip based on on-chip optics with massive tunable elements address these constraints....
Abstract Background Although the promising advancements of current therapeutic approaches is available for squamous cell carcinoma (SCC) patients, clinical treatment SCC still faces many difficulties. The surgical irreparable disfigurement and postoperative wound infection largely hamper recovery, chemo/radiotherapy leads to toxic side effects. Results Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe Fe III TA@HA has been designed through biomineralization 3+...
Abstract Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, non-contrast-enhanced MR suffers from its intrinsic problems derived blood flow-dependency, while clinical Gd-chelating contrast agents are limited by their rapid extravasation. Herein, we report a hypersensitive strategy based on interlocking stratagem zwitterionic Gd-chelate (PAA-Gd). The longitudinal molar relaxivity PAA-Gd was 4.6-times higher than...
The comprehensive evaluation of tumor vasculature that is crucial for the development, expansion, and spread cancer still remains a great challenge, especially three-dimensional (3D) vasculatures. In this study, we proposed magnetic resonance (MR) angiography strategy with interlocking stratagem zwitterionic Gd-chelate contrast agents (PAA-Gd) continuous monitoring angiogenesis progression in 3D. Owing to structure nanoscale molecular diameter, longitudinal molar relaxivity (r1) PAA-Gd was...
Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diverse vascular abnormalities. Thus, contrast agents combining T 1 and 2 effects are sought multiparameter with clinical promise, yet achieving a balance enhancement remains scientific challenge. Herein, we developed hypersensitive strategy using dual-modality NaGdF 4 nanoparticles. Because of the longer tumbling time (τ R ), nanoparticles can improve longitudinal...
Enhanced angiography based on magnetic resonance imaging (MRI) has emerged as a noninvasive, robust, and high-resolution technique for the clinical evaluation of vascular diseases. However, effects Gd-chelating contrast agents are unsatisfactory MRI enhancement owing to their short blood half-life caused by rapid extravasation, especially in microvessels. To address these issues, nanoprobes red cell membrane-coated ultrasmall NaGdF4 nanoparticles that exhibit much higher longitudinal molar...
In this study, we prepared new lignin-based pH-responsive nanoparticles (LG-M(N)-PEG NPs) and their conjugates (LG-M(N-DOX)-PEG by using polyethylene glycol (PEG), doxorubicin (DOX), alkaline lignin. these NPs, the PEG chains were conjugated to lignin an UV irradiated thiol–ene click reaction. The hydrazine β-thiopropionate bonds in NPs could conduct pH-triggered release of both DOX at acidic pH tumor cells. Results showed that LG-M(N-DOX)-PEG had a moderate particle size (48.3 ± 3.2 nm),...
Ischemic stroke is one of the leading causes disability and mortality. The collaterals provide an alternative pathway to preserve ischemic brain tissue, determine penumbra range, where neurons are salvageable. Therefore, accurately monitoring identifying crucial. Herein, a low-immunogenic nanoprobe-based MRI strategy developed simultaneously identify infarct core, distribution, distributions. nanoprobe was constructed by covalently attaching self-peptide on surface biocompatible Fe3O4...
We proposed a GSH-responsive mesoporous organosilica nanoparticles-based nanomedicine that can target tumor mitochondria. The induce apoptosis and immunogenic death of cells, realizing the chemodynamic immunological therapy cancer.
Stroke is an acute injury of the central nervous system caused by disorders cerebral blood circulation, which has become one major causes disability and death. Hemorrhage, particularly subarachnoid hemorrhage (SAH), poorest prognostic factors in stroke, related to thrombolytic therapy, been considered very dangerous. In this context, MR angiography with high sensitivity resolution developed based on biocompatible paramagnetic ultrasmall NaGdF
The effect of surface charge on the tumor-targeting in vivo is different from that at cell level. neutral nanoparticles exhibit stronger tumor uptake, while charged ones accelerate RES/MPS making their active-targeting useless.
Matrix inversion is a fundamental and widely utilized linear algebraic operation but computationally expensive in digital-clock-based platforms. Optical computing new paradigm with high speed energy efficiency, the computation can be realized through light propagation. However, there scarcity of experimentally implemented matrix inverters that exhibit both integration density capability to perform complex-valued operations existing optical systems. For first time, we demonstrated an...
There are many flow behaviors in solid tumors, including intravascular, bloodstream, and interstitial convection. Studies have shown that tumor fluid (TIF) is an important part of microenvironment regulation affects drug delivery metabolism between cells. Magnetic resonance imaging (MRI) suitable for detecting the rates liquids tissues. Clinical phase contrast PC-MRI technology has been designed to observe blood large vessels such as arteries veins; however, it not sensitive enough deal with...
Experimental and clinical studies have reported phenomena of long-range fluid flow in interstitial space. However, its behaviours functions are yet to be addressed. The imaging the stream vivo can clarify transportation route allow further understanding physiological mechanisms relevance. Here illustrate leading kidney, we design synthesize a magnetic resonance (MRI) contrast agent PAA-g-(DTPA-gadolinium). This MRI has high longitudinal relaxivity for higher large size avoid leakage across...