A5033334352- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Nanocluster Synthesis and Applications
- MRI in cancer diagnosis
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Gene expression and cancer classification
- Advancements in Battery Materials
- Quantum Dots Synthesis And Properties
- Graphene and Nanomaterials Applications
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Luminescence Properties of Advanced Materials
- Extraction and Separation Processes
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- DNA and Biological Computing
- Extracellular vesicles in disease
- Machine Learning in Bioinformatics
- Antibiotic Resistance in Bacteria
- Chromosomal and Genetic Variations
Tianjin University of Science and Technology
2025
Beijing University of Chemical Technology
2021-2024
Second Affiliated Hospital of Fujian Medical University
2020-2024
Fujian Medical University
2020-2024
Chinese Academy of Sciences
2017-2024
Qingdao University of Science and Technology
2024
Beijing National Laboratory for Molecular Sciences
2017-2024
Shenyang University of Technology
2023
Central South University
2014-2023
South China University of Technology
2021-2023
We present the genomic sequence of Legionella pneumophila, bacterial agent Legionnaires' disease, a potentially fatal pneumonia acquired from aerosolized contaminated fresh water. The genome includes 45-kilobase pair element that can exist in chromosomal and episomal forms, selective expansions important gene families, genes for unexpected metabolic pathways, previously unknown candidate virulence determinants. highlight may account Legionella's ability to survive protozoa, mammalian...
The abnormal expression of tumor-associated proteases and lowered extracellular pH are important signatures strongly associated with cancer invasion, progression, metastasis. However, their malignant effects were mainly identified using cell tissue studies. To noninvasively visualize the heterogeneous distribution these indicators in vivo further disclose collective behaviors, a target-triggered fluorescent nanoprobe composed ratiometric pH-sensitive dye, near-infrared dye (Cy5.5),...
Pancreatic ductal adenocarcinoma, as one of the most aggressive cancers, is characterized by rich desmoplastic stroma that forms a physical barrier for anticancer drugs. To address this issue, we herein report two-step sequential delivery strategy targeted therapy pancreatic cancer with gemcitabine (GEM). In strategy, metformin (MET) was first administrated to disrupt dense stroma, based on fact MET downregulated expression fibrogenic cytokine TGF-β suppress activity stellate cells (PSCs),...
Abstract Deletions of the 13q14 chromosome region are associated with B-cell chronic lymphocytic leukemia (B-CLL) and several other types cancer, suggesting presence a tumor suppressor gene. In previous studies minimal deletion (MDR) was mapped to less than 300-kilobase (kb) interval bordered by markers 173a12-82 138G4/1.3R. For identification putative gene, entire MDR (approximately 347 kb) has been sequenced, transcribed regions have identified exon trapping, EST-based full-length...
Studies reveal that malignant tumors feature uneven distributions of some key biomarkers across the entire tumorous region. Nevertheless, only very limited progress has been made towards non-invasive and quantitative detection tumor-specific in vivo, especially with clinically compatible imaging modalities. Reported here is an Fe3 O4 nanoparticle-based glutathione (GSH) responsive magnetic resonance (MRI) probe can form particle aggregates within vivo to give rise strong GSH concentration...
Nanovaccines have emerged as promising alternatives or complements to conventional cancer treatments. Despite the progresses, specific co-delivery of antigen and adjuvant their corresponding intracellular destinations for maximizing activation antitumor immune responses remains a challenge. Herein, lipid-coated iron oxide nanoparticle is delivered nanovaccine (IONP-C/O@LP) that can co-deliver peptide (CpG DNA) into cytosol lysosomes dendritic cells (DCs) through both membrane fusion...
Improving the effectiveness of cancer therapy will require tools that enable more specific targeting and improved tumor visualization. Theranostics have potential for improving care because their ability to serve as both diagnostics therapeutics; however, diagnostic is often limited by tissue-associated light absorption scattering. Herein, we develop CuInSe2@ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality accurate localization small metastases act potent ablation agents. By...
Various functional nanomaterials have been fabricated as diagnostic and therapeutic nanomedicines; however, the nanoparticles closely interact with proteins when immersed in biological fluids, forming a "protein corona" that critically alters identity of nanomedicine. Here, we developed robust strategy to construct theranostic nanoprobes based on protein-corona-coated Fe3O4 biomineralization corona. Water-soluble carboxylic were prepared by treating oleate-capped Lemieux–von Rudloff reagent....
Abstract Background Although the promising advancements of current therapeutic approaches is available for squamous cell carcinoma (SCC) patients, clinical treatment SCC still faces many difficulties. The surgical irreparable disfigurement and postoperative wound infection largely hamper recovery, chemo/radiotherapy leads to toxic side effects. Results Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe Fe III TA@HA has been designed through biomineralization 3+...
Abstract Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, non-contrast-enhanced MR suffers from its intrinsic problems derived blood flow-dependency, while clinical Gd-chelating contrast agents are limited by their rapid extravasation. Herein, we report a hypersensitive strategy based on interlocking stratagem zwitterionic Gd-chelate (PAA-Gd). The longitudinal molar relaxivity PAA-Gd was 4.6-times higher than...
The comprehensive evaluation of tumor vasculature that is crucial for the development, expansion, and spread cancer still remains a great challenge, especially three-dimensional (3D) vasculatures. In this study, we proposed magnetic resonance (MR) angiography strategy with interlocking stratagem zwitterionic Gd-chelate contrast agents (PAA-Gd) continuous monitoring angiogenesis progression in 3D. Owing to structure nanoscale molecular diameter, longitudinal molar relaxivity (r1) PAA-Gd was...
Magnetic resonance angiography (MRA) is pivotal for diagnosing panvascular diseases. However, single-modality MRA falls short in diverse vascular abnormalities. Thus, contrast agents combining T 1 and 2 effects are sought multiparameter with clinical promise, yet achieving a balance enhancement remains scientific challenge. Herein, we developed hypersensitive strategy using dual-modality NaGdF 4 nanoparticles. Because of the longer tumbling time (τ R ), nanoparticles can improve longitudinal...
An algorithm is described for mapping DNA contigs based on an interval graph (IG) representation. In general terms, the input to a set of binary overlapping relations among finite intervals spread along real line, from which generates sets ordered fragments spanning that line. The implications more case IG, called probe (PIG), in only subset cosmids are used as probes, also discussed. specific hybridizing regions YAC, takes cross-hybridization information using and orders them YAC; if gaps...
Carbon materials are most promising candidates for potassium-ion battery (PIB) anodes because of their high electrical conductivities, rational potassium storage capabilities, and low costs. However, the large volume change during K-ion insertion/extraction sluggish kinetics diffusion inhibit development carbon-based PIBs. Here, under guidance density functional theory, N/P-codoped ultrafine (≤20 nm) carbon nanoparticles (NP-CNPs) with an expanded interlayer distance, improved conductivity,...
Abstract Near‐infrared lights have received increasing attention regarding imaging applications owing to their large tissue penetration depth, high spatial resolution, and outstanding signal‐to‐noise ratio, particularly those falling in the second near‐infrared window (NIR II) of biological tissues. Rare earth nanoparticles containing Er 3+ ions are promising candidates show up‐conversion luminescence first I) down‐conversion NIR II as well. However, synthesizing particles with small size...
Abstract Imaging‐guided cancer therapy (IGCT) is rapidly emerging as a powerful precision theranostic paradigm, it can offer both diagnostic information and therapeutic benefits. But relies on advanced agents that are largely constructed top of nanomaterials. Conventionally, such by integrating different functional units, which will unnecessarily increase the size multi‐functional inevitably encounter unwanted disassociation units in vivo , leading to false diagnosis poor efficacy. In this...
Hyperlipidemia is a highly prevalent risk factor for atherosclerosis and stroke. The currently available medications used to treat cannot improve its oxidative stress damage. Consumption of hawthorn can regulate blood sugar lipids, rich fruit acid natural antioxidant that damage.The present research aimed investigate the protective effect (HFA) on hyperlipidemia determine potential molecular mechanism.Sprague-Dawley rats were fed high-fat diet (HFD) induce treated orally with acids (HFA)....
Abstract The diagnosis and treatment of triple‐negative breast cancer (TNBC) is still a grand challenge, because there rare target to be manipulated. Here, an integrated functional nanoprobe developed for precise TNBC, based on biominerals Fe 3+ rutin hydrate (RH), type natural flavonoid. Owing the adjacent phenol hydroxyl groups RH, can biomineralize with RH form colloidally stabilized by coating poly(vinyl pyrrolidone) (PVP). In nanoprobe, flavonol central scaffold as well glucoside...
The epidemic of multidrug-resistant Gram-negative bacteria is an ever-growing global concern. Polymyxin B (PMB), a kind "old fashioned" antibiotic, has been revived in clinical practice and mainly used as last-line antibiotics for otherwise untreatable serious infections because the incidence resistance to PMB currently relatively low comparison with other vivo owing unique bactericidal mechanism PMB. However, adverse side effects, including nephrotoxicity neurotoxicity, hamper its...