A5091848154- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Hepatitis C virus research
- Ginseng Biological Effects and Applications
- Hepatitis B Virus Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Medicinal Plants and Bioactive Compounds
- COVID-19 Clinical Research Studies
- Sirtuins and Resveratrol in Medicine
- MicroRNA in disease regulation
- Histiocytic Disorders and Treatments
- Autophagy in Disease and Therapy
- Neurological Disease Mechanisms and Treatments
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Long-Term Effects of COVID-19
- Pharmacological Effects and Toxicity Studies
- Sperm and Testicular Function
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Parvovirus B19 Infection Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2016-2025
Shanghai Ninth People's Hospital
2025
Northwest University
2024-2025
Qingdao University
2021-2024
Capital Medical University
2023-2024
Ministry of Education of the People's Republic of China
2019-2024
Beijing Children’s Hospital
2023-2024
Qingdao Municipal Hospital
2022-2024
Nanjing Medical University
2024
Abstract Background A recently developing pneumonia caused by SARS-CoV-2 was originated in Wuhan, China, and has quickly spread across the world. We reported clinical characteristics of 82 death cases with COVID-19 a single center. Methods Clinical data on laboratory-confirmed as infection were obtained from Wuhan local hospital’s electronic medical records according to previously designed standardized collection forms. Results All patients residents great proportion them diagnosed severe...
Composition of the gut microbiota has been linked with human immunedeficiency virus (HIV)-infected patients on antiretroviral therapy (ART). Evidence suggests that ART-treated poor CD4+ T-cell recovery have higher levels microbial translocation and immune activation. However, association remains unclear. We performed a cross-sectional study 30 healthy controls (HC) 61 HIV-infected individuals, including 15 immunological ART responders (IRs), 20 non-responders (INRs) 26 untreated individuals...
Natural products derived from medicinal plants offer convenience and therapeutic potential have inspired the development of antimicrobial agents. Thus, it is worth exploring combination nanotechnology natural products. In this study, silver nanoparticles (AgNPs) were synthesized leaf extract Ginkgo biloba (Gb), having abundant flavonoid compounds. The reaction conditions colloidal stability assessed using ultraviolet–visible spectroscopy. X-ray diffraction, transmission electron microscopy,...
Introduction: NBP is a compound isolated from celery seeds, which was approved by the National Medical Products Administration in 2002 for clinical treatment of ischemic stroke. However, brain ischemia/reperfusion (I/R) injury, related research on mitochondrial dynamics and its mechanism action still need to be further studied. The aim this study assess cerebral pathology stroke vivo , with specific focus molecular mechanisms how promotes fusion. Methods: Male C57BL/6 mice were utilized...
Background. Approximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4+ T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. Methods. Seventy-four patients were followed up regularly 3–7 years. Patients with undetectable plasma viral load (<50 copies/mL) over 12 months further classified into 2 groups: (1) immunological nonresponders, whose T-cell count was...
Cysteine-rich secretory protein 2 (CRISP2) is an important sperm and plays roles in spermatogenesis, modulation of flagellar motility, acrosome reaction, gamete fusion. Clinical evidence shows a reduced CRISP2 expression spermatozoa from asthenozoospermic patients, but the molecular mechanism underlying its reduction remains unknown. Herein, we carried out study focusing on asthenozoospermia. Initially, through analyzing methylation promoter activity sperm, observed decreased rather than...
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread widely. The aim of this study was to investigate the dynamic changes in peripheral blood lymphocyte subsets adult patients COVID-19.
Berberine (BBR), an alkaloid component isolated from Chinese medicinal herb Huang Lian, has aroused broad interests for its antitumor effect in recent years. The signal transducer and activator of transcription 3 (STAT3), plays critical roles malignant transformation progression was found to be constitutively activated a variety human cancers. In this study, we show that BBR inhibited cell proliferation, induced apoptosis, suppressed tumor spheroid formation lung cancer lines. These effects...
Ischemic stroke is a syndrome of severe neurological responses that cause neuronal death, damage to the neurovascular unit and inflammation. Notoginsenoside R1 (NG-R1) neuroprotective drug commonly used treat neurodegenerative cerebrovascular diseases. However, its potential mechanisms on regulation small molecule metabolism in ischemic are largely unknown. The aim this study was explore NG-R1 after stroke. Here, we found reduced infarct size improved deficits by ameliorating inhibiting...
Declared as pandemic by WHO, the coronavirus disease 2019 (COVID-19) pneumonia has brought great damage to human health. The uncontrollable spread and poor progression of COVID-19 have attracted much attention from all over world. We designed this study develop a prognostic nomogram incorporating Prognostic nutritional index (PNI) in patients.Patients confirmed with treated Renmin Hospital Wuhan University January February 2020 were included study. used logistic regression analysis find risk...
Nicotinamide phosphoribosyltransferase (NAMPT) maintains mitochondrial function and protects against cerebral ischemic injury by improving energy metabolism. Notoginsenoside R1 (R1), a unique constituent of Panax notoginseng, has been shown to promote the proliferation tube formation human umbilical vein endothelial cells. Whether proangiogenesis on activation NAMPT in stroke remains unclear. The purpose this study was investigate pharmacodynamic effect mechanism angiogenesis after stroke....
Mitochondrial autophagy maintains mitochondrial function and cellular homeostasis plays a critical role in the pathological process of cerebral ischemia/reperfusion injury (CIRI). Whether Gypenoside XVII (GP17) has regulatory effects on against CIRI remains unclear. The purpose this study was to investigate pharmacodynamic mechanisms GP17 after CIRI.
Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm mainly affecting young children. This study aimed to evaluate the outcomes of 449 pediatric patients enrolled in BCH-LCH 2014 study. 52.6% were classified with single-system (SS) LCH, 28.1% multisystem (MS) risk organ negative (RO-) and 19.4% MS RO+ LCH. Three hundred ninety-six (88.2%) initially treated first-line therapy based on vindesine-prednisone combination. One thirty-nine who lacked response initial treatment shifted...
Cerebral ischemic stroke (CIS) is a common cerebrovascular disease whose main risks include necrosis, apoptosis, and cerebral infarction. But few therapeutic advances prominent drugs seem to be of value for in the clinic yet. In previous study, notoginseng leaf triterpenes (PNGL) from Panax stem have been confirmed neuroprotective effects against mitochondrial damages caused by ischemia vivo. However, potential mechanisms protection not fully elaborated The oxygen glucose deprivation...
Notoginsenoside R1 (R1), a major component isolated from P. notoginseng , is phytoestrogen that exerts many neuroprotective effects in rat model of ischemic stroke. However, its long-term on neurogenesis and neurological restoration after stroke have not been investigated. The aim this study was to evaluate the functional recovery We used male Sprague-Dawley rats subjected middle cerebral artery occlusion/reperfusion (MCAO/R). administered by intraperitoneal (i.p.) injection immediately...
Hyperlipidemia is a highly prevalent risk factor for atherosclerosis and stroke. The currently available medications used to treat cannot improve its oxidative stress damage. Consumption of hawthorn can regulate blood sugar lipids, rich fruit acid natural antioxidant that damage.The present research aimed investigate the protective effect (HFA) on hyperlipidemia determine potential molecular mechanism.Sprague-Dawley rats were fed high-fat diet (HFD) induce treated orally with acids (HFA)....
Folium Ginkgo extract and tetramethylpyrazine sodium chloride injection (Xingxiong injection) is a compound preparation commonly used for treating cerebral ischaemia/reperfusion injury in ischaemic stroke China. However, its potential mechanisms on remain unknown.This study explores the of Xingxiong vivo or vitro.Sprague-Dawley (SD) rats were randomly assigned to five groups: sham (normal saline), model saline) groups (12.5, 25 50 mL/kg). The subjected 2 h middle artery occlusion (MCAO)...
Infection control and bone regeneration remain critical challenges in defect treatment. We developed a 3D-printed scaffold incorporating copper-based metal–organic framework-74 (Cu-MOF-74) within polycaprolactone/hydroxyapatite composite. The synthesized Cu-MOF-74 exhibited well-defined crystalline structure rod-like morphology, as confirmed by TEM, EDS, FTIR, XRD analyses. scaffolds hierarchical pores (100–200 μm) demonstrated tunable hydrophilicity, evidenced the water contact angles...