A5025546736- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV-related health complications and treatments
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Smart Grid Energy Management
- Hepatitis C virus research
- Pneumocystis jirovecii pneumonia detection and treatment
- Electric Power System Optimization
- Hepatitis B Virus Studies
- COVID-19 Clinical Research Studies
- Advanced Battery Technologies Research
- Electric Vehicles and Infrastructure
- Microgrid Control and Optimization
- SARS-CoV-2 and COVID-19 Research
- Optimal Power Flow Distribution
- Energy Load and Power Forecasting
- Energy, Environment, and Transportation Policies
- Liver Disease Diagnosis and Treatment
- Viral Infections and Vectors
- BIM and Construction Integration
- Power Systems and Renewable Energy
- Electric and Hybrid Vehicle Technologies
- Machine Learning and Data Classification
Central South University
2015-2025
Baotou Central Hospital
2024
Peking Union Medical College Hospital
2014-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2023
Huashan Hospital
2023
Fudan University
2023
National University of Defense Technology
2022-2023
Jiangsu University
2023
Academy of Medical Sciences
2009-2022
Tsinghua University
2017-2022
This report demonstrates that a rapid decrease of peripheral T cell subsets is unique characteristic in patients with SARS during acute infection, although total white blood counts, red and platelet counts remain relatively normal. In recovering patients, dramatic restoration was seen the periphery. Although underlying mechanism observed stage remains unknown, this clinical can facilitate an earlier more accurate diagnosis SARS.
Aging is a major risk factor for several conditions including neurodegenerative, cardiovascular diseases and cancer. Functional impairments in cellular pathways controlling genomic stability, immune control have been identified. Biomarker of senescence needed to improve vaccine response develop therapy control. To identify phenotypic signature circulating cells with aging, we enrolled 1068 Chinese healthy volunteers ranging from 18 80 years old. The decreased naïve CD4+ CD8+ T cells,...
This paper studies the electric vehicle (EV) charging scheduling problem to match stochastic wind power. Besides considering optimality of expected cost, proposed model innovatively incorporates matching degree between power and EV load into objective function. Fully taking account uncertainty dynamics in energy supply demand, this multistage is formulated as a Markov decision process. In order enhance computational efficiency, effort made two aspects. Firstly, size reduced by aggregating...
With the rapid development of electric vehicles (EVs), consequent charging demand represents a significant new load on power grids. The huge number high-rise buildings in big cities and modern technological advances have created conditions to mount on-site wind generators buildings. Since are usually equipped with large parking lots for EVs, it shows vital practical significance utilize generation charge EVs parked In this paper, we first use case study Beijing show that can potentially...
Composition of the gut microbiota has been linked with human immunedeficiency virus (HIV)-infected patients on antiretroviral therapy (ART). Evidence suggests that ART-treated poor CD4+ T-cell recovery have higher levels microbial translocation and immune activation. However, association remains unclear. We performed a cross-sectional study 30 healthy controls (HC) 61 HIV-infected individuals, including 15 immunological ART responders (IRs), 20 non-responders (INRs) 26 untreated individuals...
Electric vehicles (EVs) have experienced a rapid growth due to the economic and environmental benefits. However, substantial charging load brings challenging issues power grid. Modern technological advances huge number of high-rise buildings promoted development distributed energy resources, such as building integrated/mounted wind turbines. The issue coordinate EV with locally generated can potentially reduce impacts demand on As result, this paper investigates important problem three...
Background. Approximately 20% of human immunodeficiency virus type 1 (HIV-1)--infected adults do not normalize their CD4+ T lymphocytes after long-term effective highly active antiretroviral therapy (HAART). The mechanistic basis for this failure is unclear. Methods. Seventy-four patients were followed up regularly 3–7 years. Patients with undetectable plasma viral load (<50 copies/mL) over 12 months further classified into 2 groups: (1) immunological nonresponders, whose T-cell count was...
For decades researchers have developed various models and algorithms to look for the Optimal Power Flow (OPF) in different applications. Still research is ongoing find OPF problems present day power system challenges such as a liberalized market or large penetration of renewable energy source. Traditionally, classical mathematical optimization methods been used effectively solve conventional problems. Due emergence deregulated electricity consideration dynamic properties, however,...
Introduction Liver disease related to hepatitis B (HBV) and C (HCV) may temper the success of antiretroviral therapy (ART) in China. Limited data exist on their prevalence HIV‐positive Chinese. A multi‐centre, cross‐sectional study was carried out determine characteristics HBV HCV co‐infection patients across 12 provinces. Methods ART‐naïve were recruited from two parent cohorts established during November 2008–January 2010 August 2012–September 2014. Hepatitis surface antigen (HBsAg), e...
New power systems, predominantly based on renewable energy, necessitate active load-side management to effectively alleviate the pressures associated with balancing supply-side fluctuations and demand-side energy requirements. Concurrently, as markets continue evolve, both market ancillary services offer valuable guidance for optimal economic dispatch of industrial loads. Although substantial energy-saving potential exists within production processes, their inherent complexity, dynamic...
Most of the individuals infected with SARS coronavirus (SARS-CoV) spontaneously recovered without clinical intervention. However, immunological correlates associated patients' recovery are currently unknown. In this report, we have sequentially monitored 30 patients over a two-year period to characterize temporal changes in SARS-CoV-specific antibody responses as well cytotoxic T cell (CTL) responses. We found persistence robust and CTL all study subjects throughout period, moderate decline...
Background: Immunological memory is the basis for vaccination. Currently, longitudinal profiles of antibody responses in recovered severe acute respiratory syndrome (SARS) patients have not been fully characterized. Methods: In this study we sequentially followed up 19 SARS over a 3-y period order to characterize dynamic changes against viral components detail. addition, 4 blood samples were obtained at month 60. Results: We found that immunoglobulin G (IgG) antibodies and their neutralizing...
Purpose The incomplete immune reconstitution is a complex phenomenon among human immunodeficiency virus (HIV)-infected patients despite the fact that they have achieved persistent viral suppression under combined antiretroviral therapy. This study aims to screen and verify immunological characteristics underlying mechanisms of non-responders (INRs). Methods RNA-seq differentially expressed genes (DEGs) analysis were used explore potential INRs. Gene Ontology (GO) enrichment, ingenuity...
Background Limited information is available on the relationship between nevirapine plasma concentrations and virologic response or liver toxicity in Chinese patients with HIV infection. The objective of this prospective study was to test determine minimal therapeutic trough concentration for patients. Methods A total 227 HIV-infected, treatment naïve were enrolled into study. Blood samples taken at Ctrough (12 hr postdose) C2 (2 measurement 6 months after initiation. Therapeutic outcomes,...
To determine whether HIV-1 viruses exist in tears of patients under HAART, a cross-sectional study was designed. All participants who underwent long-term HAART with undetectable plasma viral load had detectable (n = 16) and no difference from the controls 5). Our data suggested that lacrimal gland and/or other tear-associated tissues could be new reservoirs for precautions should taken when doing eye examinations.
The HIV-1 DNA reservoir is an important marker that reflects viro-immunological status and can be affected by multiple viral or cellular factors. Determining the potential factors associated with size of benefits surveillance disease progression antiretroviral treatments.We conducted a case control study to explore may affect level DNA. total in peripheral blood at 5 time points was quantified quantitative PCR. Chronically HIV-1-infected patients whose cell-associated levels were below...
The source of secondary lower respiratory tract bacterial infections in influenza patients is not fully understood. A case–control study was conducted during the 2017–2018 epidemic period Beijing, China. Nasopharyngeal swabs were collected from 52 virologically confirmed and 24 healthy medical staff. nasopharyngeal microbiota taxonomic composition analysed using high-throughput sequencing 16S rRNA gene V3–V4 regions. super-dominant pathobiontic genus (SDPG) defined as that accounting for...
Multiagent dynamic task assignment of forest fires is a complicated optimization problem because it requires the consideration multiple factors, such as spread speed fires, firefighting agents, movement and number deployed agents. In this article, we investigate multiagent based on fire point model, objective which to minimize completion time. First, establish model for assignments. Second, prove that optimal static always makes all times same under certain assumptions. Furthermore,...
The HIV-1 infected immunological non-responders (INRs) are characterized by poor immune reconstitution after long-term treatment. Tripterygium Wilfordii Hook F (TwHF) pill is a traditional Chinese patent drug with extensive immunosuppressive effects and has been clinically proven efficacy in treating INRs.The therapeutic mechanism of TwHF pills the treatment INRs was investigated combined multi-omics analysis on clinical samples network pharmacology approach.Clinically, peripheral blood...
Persons living with human immunodeficiency virus (HIV) are at increased risk of developing cardiovascular disease. Few studies have focused on echocardiographic abnormalities in this population.China AIDS Clinical Trial 0810 is a prospective, multicenter cohort study persons HIV (PLWH). We performed an echocardiography substudy 325 PLWH. examined the prevalence left ventricular systolic dysfunction (LVSD), diastolic (DD), pulmonary arterial hypertension (PAH), and mass (ILVM) antiretroviral...