A5113570880- Spectroscopy and Chemometric Analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Optical Imaging and Spectroscopy Techniques
- Non-Invasive Vital Sign Monitoring
- Water Quality Monitoring and Analysis
- Photoacoustic and Ultrasonic Imaging
- Advanced Chemical Sensor Technologies
- Viral Infections and Vectors
- Hemodynamic Monitoring and Therapy
- Ophthalmology and Visual Impairment Studies
- Metabolism, Diabetes, and Cancer
- Traditional Chinese Medicine Studies
- Advanced Image Fusion Techniques
- Viral Infections and Outbreaks Research
- Infrared Target Detection Methodologies
- Nanoplatforms for cancer theranostics
- Liver Disease Diagnosis and Treatment
- Combustion and Detonation Processes
- Corneal surgery and disorders
- Extracellular vesicles in disease
- Image Enhancement Techniques
- Advanced Measurement and Detection Methods
- Electrical and Bioimpedance Tomography
- Plasmonic and Surface Plasmon Research
- Advanced Algorithms and Applications
Tianjin University
2016-2025
Chinese University of Hong Kong
2023-2025
Southern Medical University
2023-2025
China Pharmaceutical University
2020-2025
Dongguan People’s Hospital
2023-2025
Fujian Normal University
2025
Second Hospital of Shanxi Medical University
2022-2025
Shanxi Medical University
2022-2025
Shenzhen KangNing Hospital
2020-2024
Xiamen University
2006-2024
BackgroundSimnotrelvir is an oral 3-chymotrypsin–like protease inhibitor that has been found to have in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and potential efficacy a phase 1B trial.MethodsIn this 2–3, double-blind, randomized, placebo-controlled trial, we assigned patients who had mild-to-moderate disease 2019 (Covid-19) onset of symptoms within the past 3 days 1:1 ratio receive 750 mg simnotrelvir plus 100 ritonavir or placebo twice daily for 5...
We present the experimental demonstration of what are to our knowledge first two-dimensional planar plasmonic lenses formed by an array spatially varying cross-shaped apertures in a metallic film for Fresnel-region focusing. The design utilizes localized surface plasmon resonances occurring inside apertures, accompanied aperture geometry dependent phase shift, achieve desired spatial modulation transmitted field. performance with different configurations was evaluated using confocal scanning...
The nervous system-specific leucine-rich repeat Ig-containing protein LINGO-1 is associated with the Nogo-66 receptor complex and endowed a canonical EGF (EGFR)-like tyrosine phosphorylation site. Our studies indicate that expression elevated in substantia nigra of Parkinson's disease (PD) patients compared age-matched controls animal models PD after neurotoxic lesions. present midbrain dopaminergic (DA) neurons human rodent brain. Therefore, role cell damage responses DA was examined vitro...
Developing highly efficient catalysts for cathodes remains an important matter of the research fuel cells. Here, we report a bimetallic iron- and molybdenum-based nitrogen-doped carbon catalyst ((Fe,Mo)–N/C), acting as oxygen reduction reaction (ORR) at cathode. The was synthesized by pyrolysis complex precursor obtained through facile ion-exchange process based on hard–soft-acid–base (HSAB) principle. dilution effect Mo prevents Fe species from aggregation, leading to high content Fe....
Healthcare-associated infections (HAIs) not only bring additional medical cost to the patients but also prolong length of stay (LOS). 2119 HAI case-patients and matched control-patients were identified in 68 hospitals 14 primary sampling provinces 7 major regions China. The caused an increase 10.4 days. LOS due increased from 9.7 10.9 days different levels hospitals. There was no statistically significant difference between hospital levels. 8.2 12.6 Comparing regions, we found that South...
Abnormal tumor metabolism creates a complex immune microenvironment that plays dominant role in the metastasis of triple-negative breast cancer (TNBC). TNBC is insensitive to checkpoint blockade (ICB) therapy because insufficient cytotoxic T lymphocyte (CTL) infiltration and hyper-lactic acid-suppressive caused by abnormal glycolysis. Herein, we propose an amplified strategy based on lactic acid regulation reprogram immunosuppressive (ITM) combine it with ICB achieve enhanced antitumor...
A gold nanohole array is functionalized with a cortisol thiol derivative, and binding to monoclonal antibody conveniently detected using the sensitive shift in 1060 nm transmission peak of array. Detection also enhanced 3-fold by application secondary antibody−gold nanoparticle conjugate. This regenerable response represents more than that obtained previously for higher affinity opens way arrays immunobiosensing important biomolecules.
Understanding the mechanisms of amyloid-beta protein (Abeta) production and clearance in brain has been essential to elucidating etiology Alzheimer disease (AD). Chronically decreasing Abeta levels is an emerging therapeutic approach for AD, but no such disease-modifying agents have achieved clinical validation. Certain proteases are responsible catabolism vivo, some experimental evidence suggests they could be used as tools reduce AD. The objective this study was determine if enhancing by...
Parafibromin is a tumor suppressor protein encoded by HRPT2 , gene recently implicated in the hereditary hyperparathyroidism–jaw syndrome, parathyroid cancer, and subset of kindreds with familial isolated hyperparathyroidism. Human parafibromin binds to RNA polymerase II as part PAF1 transcriptional regulatory complex. The physiologic targets mechanism which its loss function can lead neoplastic transformation are poorly understood. We show here that interference expression or Paf1...
βII‐Spectrin (SPTBN1) is an adapter protein for Smad3/Smad4 complex formation during transforming growth factor beta (TGF‐β) signal transduction. Forty percent of SPTBN1 +/− mice spontaneously develop hepatocellular carcinoma (HCC), and most cases human HCC have significant reductions in expression. In this study, we investigated the possible mechanisms by which loss may contribute to tumorigenesis. Livers mice, compared wild‐type mouse livers, display a increase epithelial cell adhesion...
<h3>Importance</h3> Lung cancer is the leading cause of death in United States all ethnic and racial groups. The overall rate from lung higher black patients than white patients. <h3>Objective</h3> To compare prevalence types somatic alterations between cancers Differences mutational frequencies could illuminate differences prognosis lead to reduction outcome disparities by more precisely targeting patients’ treatment. <h3>Design, Setting, Participants</h3> Tumor specimens were collected...
Abstract Background Today, thrombosis is one of the most widely occurring diseases in modern life. Drugs with thrombolytic functions are effective methods treatment thrombosis. Among them, Douchi fibrinolytic enzyme (DFE) a promising agent. DFE was isolated from , typical and popular soybean-fermented food China, it can dissolve fibrin directly efficiently. A strain, Bacillus subtilis LD-8547 produced high activity has been our lab previously. Results In study, effect studied vitro vivo...
AMP-activated protein kinase (AMPK) is a crucial metabolic regulator with profound modulatory activities on inflammation. Although the anti-inflammatory benefits of AMPK activators were well-documented in experimental studies, pathological significance endogenous inflammatory disorders largely remains unknown. The present study investigated phosphorylation status and potential roles mice lipopolysaccharide (LPS)-induced lethal results indicated that LPS dose-dependently decreased level its...
Vehicle edge computing (VEC) is a new technology that can extend and storage functions to the of Internet Things (IoT) systems. For limited power delay sensitive mobile applications on Vehicles (IOV). It important offload tasks end VEC network. Still, High mobility data security privacy resource management randomness IOV brought about problems offloading VEC. To this end, study focuses in We survey principal schemes methods field classify current into different categories. also discuss...
Severe fever with thrombocytopenia syndrome (SFTS) is a life-threatening infectious disease caused by the SFTS virus (SFTSV). This study aimed to evaluate predictive power of C-reactive protein lymphocyte ratio (CLR) and establish an early-warning model for mortality. We retrospectively analyzed hospitalized patients in six clinical centers from May 2011 2022. The efficacy CLR prediction was evaluated receiver operating characteristic (ROC) analysis. A nomogram established validated. Eight...