A5101845287- Nanoplatforms for cancer theranostics
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Nanoparticle-Based Drug Delivery
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Peptidase Inhibition and Analysis
- Photodynamic Therapy Research Studies
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
- Evaluation Methods in Various Fields
- CRISPR and Genetic Engineering
- Inflammatory Bowel Disease
- Advanced biosensing and bioanalysis techniques
- interferon and immune responses
- Cancer-related Molecular Pathways
- Immune cells in cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Geoscience and Mining Technology
- Bioinformatics and Genomic Networks
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Nicotinic Acetylcholine Receptors Study
- Advanced X-ray and CT Imaging
- Dyeing and Modifying Textile Fibers
Beihang University
2025
Fujian Normal University
2023-2025
Xuzhou Medical College
2020-2024
Stomatology Hospital
2024
Kunming Medical University
2024
Ministry of Education of the People's Republic of China
2024
Ningxia University
2024
Southern Medical University
2022-2023
The Fourth People's Hospital of Ningxia Hui Autonomous Region
2022-2023
Dongguan People’s Hospital
2023
The immunotherapeutic effect elicited by photodynamic therapy (PDT) is attenuated tumor defense mechanisms associated with glutamine metabolism, including the metabolic regulation of redox homeostasis and limitation immunosuppressive microenvironment (ITM). Herein, a carrier-free nanobooster C9SN dual synergistic effects was constructed self-assembly glutaminase (GLS) inhibitor compound 968 (C968) photosensitizer Chlorin e6. C968-mediated GSH deprivation through inhibiting metabolism...
Background Interleukin (IL) 1 released from monocytes/macrophages is one of the critical determinants in mediating adverse events chimeric antigen receptor T cell (CAR-T) therapy, including cytokine release syndrome and neurotoxicity. However, molecular mechanisms IL-1 production during CAR-T therapy remain unknown. Methods The roles AIM2 α1-adrenergic (α1-AR) treatment-induced IL-1β were evaluated by gene silencing, agonist or antagonist treatment. phenotype switch macrophages response to...
Semiconducting open-shell radicals (SORs) have promising potential for the development of phototheranostic agents, enabling tumor bioimaging and boosting tumorous reactive oxygen species (ROS). Herein, a new class semiconducting perylene diimide (PDI), designated as PDI(Br)n with various numbers bromine (Br) atoms modified on PDI's bay/ortho positions is reported. demonstrated to transform into radical anion, [PDI(Br)n]•-, in reducing solution, typical g-value 2.0022. Specifically,...
Abstract Semiconductor substrates hold significant promise in surface‐enhanced Raman scattering (SERS) owing to their excellent selectivity and stability, but SERS activity is hampered by inefficient interfacial charge transfer (CT). Here, the CoSe 2 nanocages are constructed biphase junction strategy improve CT efficiency. Electron localization function (ELF) simulations demonstrated that orthorhombic phase (o‐CoSe ) exhibits higher electron delocalization compared cubic (c‐CoSe due its...
Activation of the innate immune Stimulator Interferon Genes (STING) pathway potentiates antitumor immunity. However, delivering STING agonists systemically to tumors presents a formidable challenge, and resistance monotherapy has emerged in clinical trials with diminishing natural killer (NK) cell proliferation. Here, we encapsulated agonist diABZI within polymersomes containing Type I photosensitizer (NBS), creating nanoagonist (PNBS/diABZI) for highly responsive tumor immunotherapy. This...
Abstract As prospective phototheranostic agents for cancer imaging and therapy, semiconducting organic molecule‐based nanomedicines are developed. However, near‐infrared (NIR) emission, tunable type I (O 2 • − ) II ( 1 O photoinduced reactive oxygen species (ROS) generation to boost photoimmunotherapy remains a big challenge. Herein, series of D–π–A structures, NIR absorbing perylene diimides (PDIs) with heavy atom bromide modification at the bay position PDIs prepared investigating optimal...
Despite the great achievements of nanomedicines made in cancer chemotherapy, precise tumor targeting and deep penetration are still major challenges. Many can only passively accumulate near leaky site vessels through enhanced permeability retention (EPR) effect cannot reach region tumor. To improve targeting, efficiency, an iRGD-mediated enzyme-induced gold nanoparticles system (iRGD/AuNPs-A&C) was developed by simply coadministering a tumor-homing peptide iRGD (CRGDKGPDC) with legumain...
Abstract Radiotherapy (RT) is a crucial clinical modality for cancer. However, nonselectivity, toxicity to normal tissues, and radio‐resistance severely limit RT applications. This study develops versatile X‐ray theranostic nano‐antioxidant (XTN) prevent tissues from oxidative damage induce systematic robust anticancer immunity. XTN owns NIR‐II photoacoustic (PA) imaging properties precise discrimination of the tumor margin through, thereby improving accuracy RT. Additionally, enhance cell...
Sorafenib is a standard targeted drug used to treat hepatocellular carcinoma (HCC). Notably, cytokine has been found further enhance the therapeutic effectiveness of drug. Thereby, aim this study verify whether IL-2 could increase anti-cancer effects sorafenib on liver cancer in vitro. Huh7 cells were present and cell apoptosis migration determined response treatment. Then, siRNA pathway blocker determine molecular mechanisms by which The data our illustrated that treatment induced vitro, an...
Abstract Prolonged hypersecretion of catecholamine induced by chronic stress may correlate with malignant progression cancer. β2‐adrenergic receptor (β2‐AR) overexpressed in certain cancer cells translate the signals from neuroendocrine system to interacting oncoproteins, such as Her2. In present study, we demonstrate that stimulation activates expression and proteolytic activity ADAM10 modulating miR‐199a‐5p SIRT1 also confirm induction triggers activities γ‐secretase, leading shedding Her2...
Based on the concept of "Evolutionary Traps", targeting survival essential genes obtained during tumor drug resistance can effectively eliminate resistant cells. While, it still faces limitations. In this study, lapatinib-resistant cells were used to test Traps" and no suitable target stand out because identified without accessible drug. However, a membrane protein PDPN, which is low or non-expressed in normal tissues, as highly expressed PDPN CAR-T developed showed high cytotoxicity against...
Articular cartilage defects often involve damage to both the and subchondral bone, requiring a scaffold that can meet unique needs of each tissue type establish an effective barrier between bone cartilage. In this study, we used 3D printing technology fabricate tri-phasic composed PLA/PCL-PLGA/Mg(OH)₂, which includes layer, osteochondral interface, layer. The was filled with Velvet antler polypeptides (VAP), its characterization assessed using compression testing, XRD, FTIR, SEM,...
The nervous system exerts finely tuned control over all aspects of the life an organism, including pain, sensation, growth, and development. Recent developments in tissue regeneration research have increasingly turned to small molecule peptides tailor augment biological response following loss or injury. In present study, we introduced peptide galanin (GAL) as a novel scaffold-coating agent for healing craniofacial tissues. Using immunohistochemistry, detected GAL receptors healthy...
Tumor immunotherapy targeting PD-L1 has emerged as one of the powerful tools for tumor therapy. Numerous studies indicate that tumor-targeted drugs critically have an influence on interaction between immune system and tumors by changing expression PD-L1, which is beneficial immunotherapy. Our study provided novel evidence improving drug regimen in targeted therapy immunotherapy.The SKBR3, MDA-MB-231, MCF7, 4T1, MC38 B16 cells was evaluated flow cytometry after treatment with six preclinical...
Our goal is to construct an immune-related gene prognostic risk index (IRGPRI) for pancreatic adenocarcinoma (PAAD), and clarify the immune molecular features in IRGPRI-defined PAAD subgroups benefit of checkpoint inhibitors (ICIs) therapy.Through differential expression analysis, weighted co-expression network analysis (WGCNA), univariate Cox regression 16 hub genes were identified using Cancer Genome Atlas (TCGA) dataset (n = 182) set. From these genes, we constructed IRGPRI with method...
Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis, is one of the most frequent gastrointestinal disorders worldwide. Although actual etiology IBD remains unclear, growing evidence suggests that CD4+ T cells-associated cytokines, interferon (IFN)-γ, interleukin (IL)-10 IL-17A, are crucial for occurrence IBD. It has been reported there a positive association between miRNAs development. In this study, we investigated roles hsa-miRNA-374b-5p(miRNA-374b-5p)...