A5101691212- Virus-based gene therapy research
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- RNA Interference and Gene Delivery
- Polysaccharides and Plant Cell Walls
- Plant Stress Responses and Tolerance
- Herpesvirus Infections and Treatments
- Immune cells in cancer
- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- Photosynthetic Processes and Mechanisms
- Cytokine Signaling Pathways and Interactions
- TGF-β signaling in diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Ocular Oncology and Treatments
- Plant Reproductive Biology
- Tryptophan and brain disorders
- interferon and immune responses
- Plant nutrient uptake and metabolism
- Fungal Biology and Applications
- Immune Response and Inflammation
China University of Mining and Technology
2025
Capital Medical University
2016-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
Chongqing Medical University
2024
Beijing Institute of Neurosurgery
2016-2024
Beijing Tian Tan Hospital
2021-2023
Beijing Radiation Center
2021-2023
Southern University of Science and Technology
2023
Zhejiang University
2023
Zhejiang Chinese Medical University
2023
Summary Kinesins are encoded by a large gene family involved in many basic processes of plant development. However, the number functionally identified kinesins rice is very limited. Here, we report functional characterization Brittle Culm12 ( BC12 ), encoding kinesin‐4 protein. bc12 mutants display dwarfism resulting from significant reduction cell and brittleness due to an alteration cellulose microfibril orientation wall composition. expressed mainly tissues undergoing division secondary...
Protein kinases play an important role in regulating the response to abiotic stress plant. CIPKs are plant-specific signal transducers, and some members have been identified. However, precise functions of novel still remain unknown. Here we report that HbCIPK2 is a positive regulator salt osmotic tolerance. was screened out differentially expressed fragments from halophyte Hordeum brevisubulatum by cDNA-AFLP technique, single-copy gene without intron. Expression increased salt, drought ABA...
Recurrence of Glioblastoma multiforme (GBM) seems to be the rule despite combination therapies. Cell invasion and cell proliferation are major reasons for recurrence GBM. And insulin-like growth factor binding protein 5 (IGFBP5) is most conserved IGFBPs frequently dysregulated in cancers metastatic tissues.By studying human glioma tissues, we find that IGFBP5 expression associate histopathological classification highly expressed Using mutants demonstrate knockdown inhibited invasion, whereas...
To cope with environmental stimuli, plants have evolved precise regulatory mechanisms to perceive, transduce and respond abiotic stresses that can negatively affect growth development. The CBL–CIPK signaling system is a newly emerging plant-specific Ca2+-dependent network mediating stress tolerance. CBLs may sense Ca2+ signature triggered by stresses, specific interactions novel CIPK-type kinases after binding Ca2+. CBL/CIPK complexes post-translationally phosphorylate downstream target...
// Yiqiang Zhou 1, 2 , Guishan Jin 3 Ruifang Mi Junwen Zhang Hengzhou Xu Sen Cheng Yunsheng Wenjie Song Fusheng Liu 2, 1 Brain Tumor Research Center, Beijing Neurosurgical Institute, 100050, P.R. China Department of Neurosurgery, Tiantan Hospital Affiliated to Capital Medical University, Laboratory Biomedical Materials, Correspondence to: Liu, email: liufushengs@hotmail.com Keywords: glioma stem cells, neovascularization, transdifferentiation, P4HA1 Received: November 22, 2016 Accepted:...
Coal-rock-gas composite dynamic disaster is one of the most serious disasters in deep coal mining. Many studies have shown that energy-absorbing materials can effectively prevent disasters, but current research on this kind exploratory stage, and there are problems such as low economy, poor efficiency, unclear microscopic mechanism. In paper, microcosmic potential polyoxyethylene (PEO) to control coal-rock-gas was investigated from perspective molecular simulation (MD). Firstly, adsorption...
Cytokinins (CKs) are a class of phytohormones playing essential roles in various biological processes. However, the mechanisms underlying CK transport as well its function plant growth and development far from being fully elucidated. Here, we characterize PURINE PERMEASE1 (OsPUP1) rice (Oryza sativa L.). OsPUP1 was predominantly expressed root, particularly vascular cells, treatment can induce expression. Subcellular localization analysis showed that localized to endoplasmic reticulum (ER)....
K+/Na+ homeostasis is the primary core response for plant to tolerate salinity. Halophytes have evolved novel regulatory mechanisms maintain a suitable ratio during long-term adaptation. The wild halophyte Hordeum brevisubulatum can adopt efficient strategies achieve synergistic levels of K+ and Na+ under high salt stress. However, little known about its molecular mechanism. Our previous study indicated that HbCIPK2 contributed prevention accumulation reduction. Here, we further identified...
The isocitrate dehydrogenase (IDH1/2) mutations are frequent genetic abnormalities in the majority of WHO grade II/III glioma and secondary GBM. IDH1-mutated (IDH1Mut) exhibits distinctive patterns cancer biology metabolism. In present study, we showed that bone morphogenetic proteins (BMP4) significantly upregulated IDH1Mut glioma. Further, demonstrated cancer-associated BMP4 is secreted to tumor microenvironment, which enhances migration invasion through an autocrine manner....
Glioblastoma (GBM) is an immunosuppressive, highly vascular and devastating malignant brain tumor. Even with progressive combination treatment that includes surgery, radiotherapy, chemotherapy, the prognosis for GBM patients still extremely poor. Oncolytic adenovirus (OAd) can specifically replicate in cells, permitting rapid copy of therapeutic genes it carries. Moreover, E1A essential gene adenoviral replication first expressed upon viral infection. expression be regulated by Ki67...
Abstract Background Glioblastoma (GBM) is a highly immunosuppressive and vascular malignant brain tumor. Current therapeutic strategies targeting tumor cells have limited efficacy because of the microenvironment vascularization. Glioma-associated mesenchymal stem (GA-MSCs) been identified as important stromal components microenvironment, owing to their contribution angiogenesis potential drive glioma cells. However, there are no reports on effect oncolytic Ad5-Ki67/IL-15 programmed death...
The conventional treatment strategy for glioblastoma multiforme (GBM) is surgical resection followed by radiotherapy and chemotherapy. Oncolytic adenovirotherapy a promising alternative to treatment. It provides strategic combination of direct tumor-specific cell lysis antitumor immune promotion. Despite advances in oncolytic adenovirotherapy, limitations remain, including the host's antiviral response insufficient viral infiltration into tumor. Mesenchymal stem cells (MSCs) have emerged as...